Bimodal Influence of Vitamin D in Host Response to Systemic<i>Candida</i>Infection—Vitamin D Dose Matters

Lim, Joan Hui Juan; Ravikumar, Sharada; Wang, Yan Ming; Thamboo, Thomas Paulraj; Ong, Lizhen; Chen, Jinmiao; Goh, Jessamine Geraldine; Tay, Sen Hee; Chengchen, Lufei; Win, Mar Soe; Leong, Winnie; Lau, Titus; Foo, Roger; Mirza, Haris; Tan, Kevin S. W.; Sethi, Sunil; Khoo, Ai Leng; Chng, Wee Joo; Osato, Motomi; Netea, Mihai G.; Wang, Yue; Chai, Louis Yi Ann

doi:10.1093/infdis/jiv033

Cited by 29 publications

(24 citation statements)

References 38 publications

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“…From the longitudinal data by Lundqvist et al [14] it can be assumed that mothers in the present study who were insufficient post-partum may also have been insufficient during pregnancy. Although the confidence interval of the estimate was wide, resulting in uncertainty, these findings could be consistent with studies reporting vitamin D insufficiency to be associated with susceptibility to a variety of infections as for example respiratory tract infections and candidemia [5] [21] and that vitamin D modulates the immune response to Candida [2]. Cut-off levels for vitamin D were originally set in relation to the role of vitamin D in bone mineralization, with levels <25 nmol/L (10 ng/mL) often referred to vitamin D deficiency and <50 nmol/L (20 ng/mL) as vitamin D insufficiency [11], both associated with decreased bone mineralization and increased fracture risk.…”

Section: Health and Vitamin D Insufficiencysupporting

confidence: 84%

“…Vitamin D modulates immune function influencing different cell types and it has been shown that vitamin D modify proinflammatory cytokine responses [2] [3] [4]. Further, patients with candidemia had lower levels of vitamin D [5]. Pregnancy and the following postpartum period is a period in life with pronounced vulnerability for vitamin D insufficiency.…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D Insufficiency among Women Post-Partum in Northern Sweden—A Public Health Concern

Hasslöf¹,

Videhult²,

Silfverdal³

et al. 2017

FNS

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Pregnancy and post-partum represent a period of susceptibility for vitamin D insufficiency. This study investigated S-25 [OH] D levels in women in northern Sweden 4 weeks post-partum and its association with selected background factors. Blood from 100 healthy women were analyzed for iron status and serum levels of S-25[OH] D using ionization-mass spectrometry (HPLC-APCI-MS). ˂50 nmol/L was categorized as insufficiency and ˂25 nmol/L as deficiency. Maternal BMI, dietary habits, fungal infections during pregnancy, and infant birth characteristics were collected using questionnaires and medical charts. 58% were vitamin D insufficient whereas 10% had deficiency. Insufficiency was most common during winter (OR = 2.77; 95% CI = 1.1 -6.96) and women with deficiency reported lower milk consumption; 11.3 ± 22.8 intakes per months vs. 34.0 ± 28.9 for those above 25 nmol/L (p < 0.05). Vitamin D-insufficient women had lower serum ferritin levels (p < 0.01) and higher serum transferrin levels (p < 0.05). A history of vaginal fungal infection during pregnancy was associated with insufficiency (OR = 5.10; 95% CI = 1.01 -25.73), however, the confidence interval of the estimate was wide, resulting in uncertainty. It is concluded that vitamin D insufficiency 4 weeks post-partum was common in women living at 63˚49'N. The odds of being insufficient were increased during winter whereas milk consumption was negatively associated with deficiency. The low vitamin D-levels particularly during winter is a public health concern. From a public health perspective it has to be considered whether dietary advices alone should be modified or if supplementation with vitamin D during pregnancy and the post-partum period also is needed.

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Section: Health and Vitamin D Insufficiencysupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Vitamin D Insufficiency among Women Post-Partum in Northern Sweden—A Public Health Concern

Hasslöf¹,

Videhult²,

Silfverdal³

et al. 2017

FNS

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Section: Vitamin D and Fungal Infectionsmentioning

confidence: 99%

“…In another experimental study, Candida -infected mice treated with low-dose 1,25(OH) 2 -VD had reduced fungal burden and better survival when compared with untreated mice [ 108 ]. However, those animals treated with higher doses of 1,25(OH) 2 -VD (0.1 and 1 μg/kg) had poorer outcomes [ 108 ]. The authors concluded that the beneficial immune response of VD supplementation was only achieved with lower doses of 1,25(OH) 2 -VD (i.e., 0.001 and 0.01 μg/kg) [ 108 ].…”

Section: Vitamin D and Fungal Infectionsmentioning

confidence: 99%

Vitamin D and Infectious Diseases: Simple Bystander or Contributing Factor?

et al. 2017

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Vitamin D (VD) is a fat-soluble steroid essential for life in higher animals. It is technically a pro-hormone present in few food types and produced endogenously in the skin by a photochemical reaction. In recent decades, several studies have suggested that VD contributes to diverse processes extending far beyond mineral homeostasis. The machinery for VD production and its receptor have been reported in multiple tissues, where they have a pivotal role in modulating the immune system. Similarly, vitamin D deficiency (VDD) has been in the spotlight as a major global public healthcare burden. VDD is highly prevalent throughout different regions of the world, including tropical and subtropical countries. Moreover, VDD may affect host immunity leading to an increased incidence and severity of several infectious diseases. In this review, we discuss new insights on VD physiology as well as the relationship between VD status and various infectious diseases such as tuberculosis, respiratory tract infections, human immunodeficiency virus, fungal infections and sepsis. Finally, we critically review the latest evidence on VD monitoring and supplementation in the setting of infectious diseases.

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“…Animal models and clinical trials have demonstrated the protective effect of vitamin supplementation in several infectious diseases15161718. Indeed, vitamin A or vitamin D supplementation has been proposed as treatment option in diseases such as measles and tuberculosis, respectively1519.…”

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confidence: 99%

Differential Effects of Vitamins A and D on the Transcriptional Landscape of Human Monocytes during Infection

Klassert

Bräuer

Hölzer

et al. 2017

Sci Rep

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Vitamin A and vitamin D are essential nutrients with a wide range of pleiotropic effects in humans. Beyond their well-documented roles in cellular differentiation, embryogenesis, tissue maintenance and bone/calcium homeostasis, both vitamins have attracted considerable attention due to their association with-immunological traits. Nevertheless, our knowledge of their immunomodulatory potential during infection is restricted to single gene-centric studies, which do not reflect the complexity of immune processes. In the present study, we performed a comprehensive RNA-seq-based approach to define the whole immunomodulatory role of vitamins A and D during infection. Using human monocytes as host cells, we characterized the differential role of both vitamins upon infection with three different pathogens: Aspergillus fumigatus, Candida albicans and Escherichia coli. Both vitamins showed an unexpected ability to counteract the pathogen-induced transcriptional responses. Upon infection, we identified 346 and 176 immune-relevant genes that were regulated by atRA and vitD, respectively. This immunomodulatory activity was dependent on the inflammatory stimulus, allowing us to distinguish regulatory patterns which were specific for each stimulatory setting. Moreover, we explored possible direct and indirect mechanisms of vitamin-mediated regulation of the immune response. Our findings highlight the importance of vitamin-monitoring in critically ill patients. Moreover, our results underpin the potential of atRA and vitD as therapeutic options for anti-inflammatory treatment.

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Bimodal Influence of Vitamin D in Host Response to SystemicCandidaInfection—Vitamin D Dose Matters

Cited by 29 publications

References 38 publications

Vitamin D Insufficiency among Women Post-Partum in Northern Sweden—A Public Health Concern

Vitamin D Insufficiency among Women Post-Partum in Northern Sweden—A Public Health Concern

Vitamin D and Infectious Diseases: Simple Bystander or Contributing Factor?

Differential Effects of Vitamins A and D on the Transcriptional Landscape of Human Monocytes during Infection

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