Bimodal Nd-Doped LuVO4 Nanoprobes Functionalized with Polyacrilic Acid for X-Ray Computed Tomography and NIR Luminescent Imaging

Núñez, Nuria O.; Cussó, F.; Cantelar, Eugenio; Martín-Gracia, Beatriz; Fuente, Jesús M. de la; Corral, Ariadna; Balcerzyk, Marcin; Ocaña, Manuel

doi:10.3390/nano10010149

Cited by 14 publications

(13 citation statements)

References 19 publications

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“…PAA is a weak polyelectrolyte and has been used in several biomedical applications such as immunological studies, drug delivery, and enzyme immobilization. Many studies have revealed that PAA as a polymer is used in combination with other materials in various biomaterials (26,27,17).…”

Section: Discussion Discussionmentioning

confidence: 99%

Investigation of Polyacrylic Acid Toxicity in Human Breast Cancer (MCF-7) and Mouse Fibroblast (L-929) Cell Lines

Ersöz

Allahverdiyev²

2021

The EuroBiotech Journal

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In recent years, biopolymers have been widely used in various fields of medicine. Before using any polymer, its biocompatibility should be examined. Polyacrylic acid (PAA), a polyelectrolyte, is known to be used as an adjuvant effect in immunology, anti-thrombogenic effect in medical experiments, and as a carrier in drug delivery systems. Although there are studies on various conjugates and nanoparticles of PAA, studies on its toxicity alone are limited. Determination of toxicity in biopolymer studies is extremely important. Cultures of various cells are used for toxicity analyses. This study aimed to investigate the toxicity of PAA in human breast cancer (MCF-7) and mouse fibroblast (L-929) cell lines by various methods. Cell culture, 3-(4,5-dimethyltriazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), trypan blue and 4,6-diamidino 2 phenylindole (DAPI) methods were used in the study. The half-maximal effective concentration (EC50) value of PAA was 6.6 mg/ml in MCF 7 cells and 1.8 mg/ ml in L-929 cells. Apoptosis was observed in cells on the increasing PAA concentration with DAPI. With these results, the cytotoxic properties of PAA were determined in vitro. Accordingly, the biocompatibility of polymers to be used in modeling should be supported by in vitro and in vivo studies.

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Section: Discussion Discussionmentioning

confidence: 99%

Investigation of Polyacrylic Acid Toxicity in Human Breast Cancer (MCF-7) and Mouse Fibroblast (L-929) Cell Lines

Ersöz

Allahverdiyev²

2021

The EuroBiotech Journal

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“…Uniform Nd 3+ -doped LuVO 4 nanophosphors were produced and surface-coated with PAA; these nanoparticles are in a colloidal range in physiological pH range and have excellent stability to survive in the cell. Because of these features, these may be used as a bimodal probe for X-ray computed tomography and NIR luminous bioimaging [ 197 ] CdSe/Cu quantum dot conjugates with biocompatible polyacrylic acid functionalization were produced for bio labeling, bioimaging, and biomolecule detection applications [ 198 ].…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Polyacrylic Acid Nanoplatforms: Antimicrobial, Tissue Engineering, and Cancer Theranostic Applications

et al. 2022

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Polyacrylic acid (PAA) is a non-toxic, biocompatible, and biodegradable polymer that gained lots of interest in recent years. PAA nano-derivatives can be obtained by chemical modification of carboxyl groups with superior chemical properties in comparison to unmodified PAA. For example, nano-particles produced from PAA derivatives can be used to deliver drugs due to their stability and biocompatibility. PAA and its nanoconjugates could also be regarded as stimuli-responsive platforms that make them ideal for drug delivery and antimicrobial applications. These properties make PAA a good candidate for conventional and novel drug carrier systems. Here, we started with synthesis approaches, structure characteristics, and other architectures of PAA nanoplatforms. Then, different conjugations of PAA/nanostructures and their potential in various fields of nanomedicine such as antimicrobial, anticancer, imaging, biosensor, and tissue engineering were discussed. Finally, biocompatibility and challenges of PAA nanoplatforms were highlighted. This review will provide fundamental knowledge and current information connected to the PAA nanoplatforms and their applications in biological fields for a broad audience of researchers, engineers, and newcomers. In this light, PAA nanoplatforms could have great potential for the research and development of new nano vaccines and nano drugs in the future.

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“…CT, which can form 3D visual reconstruction of interested tissues given by the different X-rays attenuation degrees of different tissues, is a powerful noninvasive imaging technology with advantages of high spatial resolution, accurate anatomical information, and relatively affordable price ( Murakami and Nakahara, 2014 ). To further increase the visibility of internal body structure, CAs used in CT are required to provide different X-rays attenuation degrees from the surrounding organs ( Nunez et al, 2020 ). X-rays are thereby more or less absorbed by them than by body constituents, particularly by water.…”

Section: Bimodal Imaging Of Tumor Based On Near-infrared-i Fluorescencementioning

confidence: 99%

NIR-I Dye-Based Probe: A New Window for Bimodal Tumor Theranostics

et al. 2022

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Near-infrared (NIR, 650–1700 nm) bioimaging has emerged as a powerful strategy in tumor diagnosis. In particular, NIR-I fluorescence imaging (650–950 nm) has drawn more attention, benefiting from the high quantum yield and good biocompatibility. Since their biomedical applications are slightly limited by their relatively low penetration depth, NIR-I fluorescence imaging probes have been under extensive development in recent years. This review summarizes the particular application of the NIR-I fluorescent dye-contained bimodal probes, with emphasis on related nanoprobes. These probes have enabled us to overcome the drawbacks of individual imaging modalities as well as achieve synergistic imaging. Meanwhile, the application of these NIR-I fluorescence-based bimodal probes for cancer theranostics is highlighted.

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Bimodal Nd-Doped LuVO4 Nanoprobes Functionalized with Polyacrilic Acid for X-Ray Computed Tomography and NIR Luminescent Imaging

Cited by 14 publications

References 19 publications

Investigation of Polyacrylic Acid Toxicity in Human Breast Cancer (MCF-7) and Mouse Fibroblast (L-929) Cell Lines

Investigation of Polyacrylic Acid Toxicity in Human Breast Cancer (MCF-7) and Mouse Fibroblast (L-929) Cell Lines

Polyacrylic Acid Nanoplatforms: Antimicrobial, Tissue Engineering, and Cancer Theranostic Applications

NIR-I Dye-Based Probe: A New Window for Bimodal Tumor Theranostics

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