Bin1: A New Player in IBD Barrier Dysfunction

Ryu, Hyunji; Posca, Daniela

doi:10.1007/s10620-012-2228-y

Cited by 4 publications

(4 citation statements)

References 22 publications

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“…The attenuation of Bin1 reduced the severity in an experimental colitis model through the enhancement of epithelial barrier function . Moreover, the Bin1 antibody has been reported to display the alteration influence on tight junction, as well as the improvement of barrier function . The decreased expression of Bin1 in the PEP treatment group suggested a supporting impact of PEP on gut mucosal barrier function and integrity.…”

Section: Discussionmentioning

confidence: 95%

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Impacts of Dietary Pleurotus eryngii Polysaccharide on Nutrient Digestion, Metabolism, and Immune Response of the Small Intestine and Colon—An iTRAQ‐Based Proteomic Analysis

Kimatu

Zhao

et al. 2018

Proteomics

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Pleurotus eryngii polysaccharides have been shown to exert significant biological activities to the host. However, few studies have been conducted on its effects on gastrointestinal tract (GIT) health alteration. In the present study, small intestinal and colonic proteome alterations generated by dietary supplementation with a novel homogeneous P. eryngii polysaccharide (PEP) in C57BL/6 mice, based on the isobaric tag for relative and absolute quantification (iTRAQ) proteomics, are investigated. Compared to the control group, PEP supplementation result in a total of 113 and 194 significant differential proteins (DPs) in the small intestine and colon, respectively. Interestingly, DPs in small intestine are mainly related to the transport and biosynthetic process, along with the digestion and absorption pathway of nutrients, whereas the colonic DPs are significantly found participating in numerous metabolic processes. Moreover, the alterations of some DPs in small intestine and colon are speculated to correlate with the colonic microbiota structure and are involved in the regulation of host immune response. Subsequently, some critical DPs of small intestine and colon are selected and validated by Western blotting. The current research facilitated the generation of potential insights into the health benefit activities and functional mechanisms of polysaccharides from P. eryngii.

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Section: Discussionmentioning

confidence: 95%

“…[56] Moreover, the Bin1 antibody has been reported to display the alteration influence on tight junction, as well as the improvement of barrier function. [57] The decreased expression of Bin1 in the PEP treatment group suggested a supporting impact of PEP on gut mucosal barrier function and integrity.…”

Section: Proteins Associated With the Host Immune Responsementioning

confidence: 96%

Impacts of Dietary Pleurotus eryngii Polysaccharide on Nutrient Digestion, Metabolism, and Immune Response of the Small Intestine and Colon—An iTRAQ‐Based Proteomic Analysis

Kimatu

Zhao

et al. 2018

Proteomics

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“…Bridging Integrator (BinI) transgenic mice exhibit modified intestinal permeability through the action on intestinal tight junctional maintenance [ 77 ]. Interestingly, ablating BIN1 does not appear to modify histological appearance of tissues alone, but does increase functional resistance of mice to action by dextran sodium sulfateinduced colitis: treated mice exhibited increased survival, and decreased clinical manifestations of IBD such as hematochezia, diarrhea, and weight loss that was specifically associated with immune dysfunction, and not with general disruption of tight junction permeability as documented by treatment of control mice with phorbol ester or sodium caprate [ 77 ].…”

Section: Transgenic Animal Models Of Crohn's Diseasementioning

confidence: 99%

“… References to each model are as follows: 1 [ 51 52 53 ]. 2 http://jaxmice.jax.org/strain/003451.html; 3 [ 54 ]; 4 [ 56 ]; 5 http:/jaxmice.jax.org/strain/003008.html; 6 [ 61 62 87 ]; 7 [ 50 65 ]; 8 [ 68 ]; 9 [ 33 ]; 10 [ 26 45 88 ]; 11 [ 26 ]; 12 [ 54 ]; 13 [ 71 ]; 14 [ 33 68 ]; 15 [ 68 ], http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE6980; 16 [ 68 72 ], http://jaxmice.jax.org/strain/025630.html; 17 [ 77 ]; 18 [ 33 ]; 19 [ 7 45 78 ]; 20 [ 8 45 59 ], http://jaxmice.jax.org/list/ra1655.html, http://jaxmice.jax.org/jaxnotes/502/502a.html; 21 [ 8 59 ] …”

Section: Tablementioning

confidence: 99%

Spontaneous and transgenic rodent models of inflammatory bowel disease

Prattis

2015

Lab Anim Res

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Inflammatory Bowel Disease (IBD) is a multifactorial disorder with many different putative influences mediating disease onset, severity, progression and diminution. Spontaneous natural IBD is classically expressed as Crohn's Disease (CD) and Ulcerative Colitis (UC) commonly found in primates; lymphoplasmocytic enteritis, eosinophilic gastritis and colitis, and ulcerative colitis with neuronal hyperplasia in dogs; and colitis in horses. Spontaneous inflammatory bowel disease has been noted in a number of rodent models which differ in genetic strain background, induced mutation, microbiota influences and immunopathogenic pathways. Histological lesions in Crohn's Disease feature noncaseating granulomatous inflammation while UC lesions typically exhibit ulceration, lamina propria inflammatory infiltrates and lack of granuloma development. Intestinal inflammation caused by CD and UC is also associated with increased incidence of intestinal neoplasia. Transgenic murine models have determined underlying etiological influences and appropriate therapeutic targets in IBD. This literature review will discuss current opinion and findings in spontaneous IBD, highlight selected transgenic rodent models of IBD and discuss their respective pathogenic mechanisms. It is very important to provide accommodation of induced putative deficits in activities of daily living and to assess discomfort and pain levels in the face of significant morbidity and/or mortality in these models. Epigenetic, environmental (microbiome, metabolome) and nutritional factors are important in IBD pathogenesis, and evaluating ways in which they influence disease expression represent potential investigative approaches with the greatest potential for new discoveries.

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Bridging Integrator 1 (BIN1)

Turton

Morgan

2013

Genetic Variants in Alzheimer's Disease

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Bin1: A New Player in IBD Barrier Dysfunction

Cited by 4 publications

References 22 publications

Impacts of Dietary Pleurotus eryngii Polysaccharide on Nutrient Digestion, Metabolism, and Immune Response of the Small Intestine and Colon—An iTRAQ‐Based Proteomic Analysis

Impacts of Dietary Pleurotus eryngii Polysaccharide on Nutrient Digestion, Metabolism, and Immune Response of the Small Intestine and Colon—An iTRAQ‐Based Proteomic Analysis

Spontaneous and transgenic rodent models of inflammatory bowel disease

Bridging Integrator 1 (BIN1)

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