Binary titanium alloys as dental implant materials—a review

Liu, Xiaotian; Chen, Shuyang; Tsoi, James Kit‐Hon; Matinlinna, Jukka Pekka

doi:10.1093/rb/rbx027

Cited by 207 publications

(113 citation statements)

References 102 publications

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“…Ti is attractive due to its mechanical strength and biological inertness as its alloys are widely used in dental and orthopaedic applications. Zr‐based biomaterials are also widely used in the clinic, and zirconia ceramics are a class of biocompatible materials with comparable properties to those of Ti .…”

Section: Resultsmentioning

confidence: 99%

3D printing hybrid organometallic polymer‐based biomaterials via laser two‐photon polymerization

Balčiūnas

Baldock

Dreižė

et al. 2019

Polymer International

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Materials with microscale structures are gaining increasing interest due to their range of technical and medical applications. Additive manufacturing approaches to such objects via laser two‐photon polymerization, also known as multiphoton fabrication, enable the creation of new materials with diverse and tunable properties. Here, we investigate the properties of 3D structures composed of organometallic polymers incorporating aluminium, titanium, vanadium and zirconium. The organometallic polymer‐based materials were analysed using a variety of techniques including SEM, energy‐dispersive X‐ray spectroscopy, X‐ray photoelectron spectroscopy analysis and contact angle measurements and their biocompatibility was tested in vitro. Cell viability and mode of death were determined by 3‐(4,5‐dimethyl‐2‐thiazolyl)‐2,5‐diphenyl‐2H‐tetrazolium bromide (MTT) assay and acridine orange/ethidium bromide staining. Polymers incorporating Al, Ti and Zr supported cell adhesion and proliferation, and showed low toxicity in vitro, whereas the organometallic polymer incorporating V was shown to be cytotoxic. Inductively coupled plasma optical emission spectrometry suggested that leaching of the V from the organometallic polymer is the likely cause of this. The preparation of the organometallic polymers is straightforward and both simple 2D and complex 3D structures can be fabricated with ease. Resolution tests of the newly developed organometallic polymer incorporating Al show that suspended lines with widths down to 200 nm can be fabricated. We believe that the materials described in this work show promising properties for the development of objects with sub‐micron features for biomedical applications (e.g. biosensors, drug delivery devices, tissue scaffolds etc.). © 2019 The Authors. Polymer International published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

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Section: Resultsmentioning

confidence: 99%

3D printing hybrid organometallic polymer‐based biomaterials via laser two‐photon polymerization

Balčiūnas

Baldock

Dreižė

et al. 2019

Polymer International

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“…Ti and its alloys are the most commonly used materials for dental applications due to their superior biocompatibility, corrosion resistance, and excellent mechanical properties (Liu et al, 2017). These properties result from the formation of a continuous, amorphous, highly adherent, and stable titanium oxide layer (TiO 2 ).…”

Section: The Relevance Of Bio-tribocorrosion In Dentistry and State Omentioning

confidence: 99%

Progression of Bio-Tribocorrosion in Implant Dentistry

et al. 2020

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Oral rehabilitation devices are susceptible to bio-tribocorrosion phenomena in the oral environment due to the synergism of wear, chemical, biochemical, and microbiological processes. This review summarizes the clinical problems and advances obtained based on current scientific evidence as well as the influence of tribological fundamentals, testing methodologies, and protocols in tribocorrosion analyses. The main clinical question related to oral rehabilitation with dental implants is the treatment failure, which is influenced by material degradation. Titanium-based implants are exposed to wear and corrosion challenges in the oral environment since the implantation and along the lifetime service. The titanium (Ti) properties such as structural material, connection design, surface treatments, alloying elements are influencing factors for material behavior. In addition, wear-corrosion factors such as cyclic loads, micromovements, oral biofilm, decontamination methods are also associated with dental implants degradation. These environmental conditions to which dental implants are submitted leads to the release of Ti particles and ions with cytotoxic and harmful effects on peri-implant surrounding tissues. In this context, the current state of the art of bio-tribocorrosion over the last decade has been steadily increasing to understand material degradation. The basic test system used to translate the tribocorrosion phenomena in the oral environment to the bench consists of electrochemical and tribological synergic analysis. The mechanical (applied load, frequency, stroke distance, and number of cycles) and electrochemical (solution composition, concentration of anions, and pH) test conditions are determinants for materials tribocorrosion performance. To overcome the tribocorrosion phenomena some strategies have been used such as alloying elements for Ti-alloys manufacture, surface treatments, and biomolecules immobilization. Further studies need to have the tribocorrosion analyses as the basis for new smart materials development considering the importance of such aspects for the biomaterial clinical behavior. Finally, tribological tests are relevant strategies for understanding the mechanisms of degradation in the oral environment and for providing a way to improve the clinical outcomes of dental implants.

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“…However, for implants that experience large flexural loads, a metal is always required. The best results were obtained by using titanium and its alloys [15,16], most remarkably Ti-6Al-4V (no longer in use due to Al and V ion leakage), Ti-13Nb-13Zr and Ti-12Mo-6Zr [17]. Notably, an alloy of Ti-3Au shows excellent mechanical and biochemical properties, but unfortunately it is prohibitively expensive [18].…”

Section: Introductionmentioning

confidence: 99%

Development of Vitroceramic Coatings and Analysis of Their Suitability for Biomedical Applications

et al. 2019

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Within the field of tissue engineering, thin films have been studied to improve implant fixation of metallic or ceramic materials in bone, connective tissue, oral mucosa or skin. In this context, to enhance their suitability as implantable devices, titanium-based substrates received a superficial vitroceramic coating by means of laser ablation. Further, this study describes the details of fabrication and corresponding tests in order to demonstrate the bioactivity and biocompatibility of the newly engineered surfaces. Thus, the metallic supports were covered with a complex material composed of SiO 2 , P 2 O 5 , CaO, MgO, ZnO and CaF 2 , in the form of thin layers via a physical deposition techniques, namely pulsed laser deposition. The resulting products were characterized by X-ray diffraction, Fourier-transform infrared spectroscopy, scanning and transmission electron microscopy coupled with energy dispersive X-ray spectroscopy, selected area electron diffraction, and electron energy loss spectroscopy. It was found that a higher substrate temperature and a lower working pressure lead to the highest quality film. Finally, the samples biocompatibility was assessed and they were found to be bioactive after simulated body fluid soaking and biocompatible through the MTT cell viability test.Coatings 2019, 9, 671 2 of 13 drawbacks, like fibrous tissue growth, slow osseointegration and reduced close contact with the host bone, were noticed upon wider use of titanium alloy implants [19]. Thus, the quest is to develop a composite material with all the mechanical properties of titanium alloys, encapsulated in a leak-proof ceramic, that can be biologically preactivated prior to implant [20,21].With the advent of laser-based additive manufacturing [22], such composite material is now a reality. In this case, a commercial or custom-made ceramic target is ablated by a pulsed laser, a plume of plasma is generated and directed towards the metallic substrate, upon which it settles, forming a thin layer that physically binds to the support [23,24]. Our research group has already reported the growth of nanostructured akermanite-based thin films by pulsed laser deposition, with good biocompatibility and bioactivity [25]. Since both the target characteristics and processing conditions strongly influence the properties of the final coatings [26], more studies are necessary in order to elucidate which are the driven factors and optimized set of parameters.Thus, the aim of this work is to produce a material that is durable and readily implantable. A type of vitroceramic coatings on titanium substrates were developed, characterized and then immersed in simulated biological fluid to be coated with a hydroxyapatite-like layer and demonstrate its bioactivity [27,28]. Further biological tests indicated that, indeed, this combination of materials resulted in an artifact that responds well to the in vitro cell proliferation. Author Contributions: Conceptualization, S.-I.J. and C.B.; methodology, C.B. and D.M.; validation, S.-I.J.; investigation...

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Binary titanium alloys as dental implant materials—a review

Cited by 207 publications

References 102 publications

3D printing hybrid organometallic polymer‐based biomaterials via laser two‐photon polymerization

3D printing hybrid organometallic polymer‐based biomaterials via laser two‐photon polymerization

Progression of Bio-Tribocorrosion in Implant Dentistry

Development of Vitroceramic Coatings and Analysis of Their Suitability for Biomedical Applications

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