“… 55 , 78 , 79 The input-output mapping is inevitably relaxed for adaptive modulation, and feedback-based optimization is therefore required. These optimization algorithms, including evolutional algorithms, 79 , 80 , 81 , 82 , 83 , 84 , 85 artificial intelligence algorithms, 86 , 87 , 88 and their combination, 89 , 90 can instantly modify the modulation patterns while screening the feedback variations. Encountering stronger variations (e.g., a dynamic medium), optimization with physics prior 91 , 92 , 93 works more efficiently, which quantifies the error in the optimized wavefront for optical focusing, while previously the number of to-be-corrected pixels on a spatial light modulator (SLM) is empirically guessed.…”