Binasal Visual Field Defects from Simultaneous Bilateral Retinal Infarctions in Sickle Cell Disease

Cusick, Michael; Toma, Hassanain S.; Hwang, Thomas S.; Brown, Justin C.; Miller, Neil R.; Adams, Nicholas

doi:10.1016/j.ajo.2006.12.002

Cited by 18 publications

(10 citation statements)

References 4 publications

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“…Collectively, these are manifestations of stage I-II sickle cell retinopathy. Bilateral macular occlusive events may present with binasal field defects [15]. Electrophysiology indicates a selective early involvement of the inner retina in HbSS patients, which may be compatible with vascular occlusions in the superficial and deep capillary plexi in the inner retina [16].…”

Section: Non-proliferative Sickle Cell Retinopathy (Stages I-ii)mentioning

confidence: 99%

Sickle cell retinopathy. A focused review

Elsayed

Mura

Dhibi

et al. 2019

Graefes Arch Clin Exp Ophthalmol

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Purpose To provide a focused review of sickle cell retinopathy in the light of recent advances in the pathogenesis, multimodal retinal imaging, management of the condition, and migration trends, which may lead to increased prevalence of the condition in the Western world. Methods Non-systematic focused literature review. Results Sickle retinopathy results from aggregation of abnormal hemoglobin in the red blood cells in the retinal microcirculation, leading to reduced deformability of the red blood cells, stagnant blood flow in the retinal precapillary arterioles, thrombosis, and ischemia. This may be precipitated by hypoxia, acidosis, and hyperosmolarity. Sickle retinopathy may result in sight threatening complications, such as paracentral middle maculopathy or sequelae of proliferative retinopathy, such as vitreous hemorrhage and retinal detachment. New imaging modalities, such as wide-field imaging and optical coherence tomography angiography, have revealed the microstructural features of sickle retinopathy, enabling earlier diagnosis. The vascular growth factor ANGPTL-4 has recently been identified as a potential mediator of progression to proliferative retinopathy and may represent a possible therapeutic target. Laser therapy should be considered for proliferative retinopathy in order to prevent visual loss; however, the evidence is not very strong. With recent development of wide-field imaging, targeted laser to ischemic retina may prove to be beneficial. Exact control of intraoperative intraocular pressure, including valved trocar vitrectomy systems, may improve the outcomes of vitreoretinal surgery for complications, such as vitreous hemorrhage and retinal detachment. Stem cell transplantation and gene therapy are potentially curative treatments, which may prevent retinopathy. Conclusions There is lack of evidence regarding the optimal management of sickle retinopathy. Further study is needed to determine if recent progress in the understanding of the pathophysiology and diagnosis of sickle retinopathy may translate into improved management and outcome.

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Section: Non-proliferative Sickle Cell Retinopathy (Stages I-ii)mentioning

confidence: 99%

Sickle cell retinopathy. A focused review

Elsayed

Mura

Dhibi

et al. 2019

Graefes Arch Clin Exp Ophthalmol

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“… 36 – 39 For some unknown reasons, PSCR is uncommonly manifested by simultaneous bilateral macular occlusive events. 40 These retinal vascular occlusions cause tissue ischemia and release of angiogenic mediators that promote retinal neovascularization (ie, neovascular proliferation). 41 – 43 Then, this neovascularization, a hallmark in PSCR patients, grows anteriorly from the perfused to non-perfused (avascular) retina to reach the posterior ischemic retina, and is characterized by flat vessels denominated sea fan structures ( Figure 3 ) for their close resemblance to the marine invertebrate Gorgonia flabellum (Venus sea fan).…”

Section: Pathogenesis Clinical Manifestations and Complications Of mentioning

confidence: 99%

Sickle cell retinopathy: improving care with a multidisciplinary approach

Menaa¹,

Khan²,

Uzair³

et al. 2017

JMDH

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Sickle cell retinopathy (SCR) is the most representative ophthalmologic complication of sickle cell disease (SCD), a hemoglobinopathy affecting both adults and children. SCR presents a wide spectrum of manifestations and may even lead to irreversible vision loss if not properly diagnosed and treated at the earliest. Over the past decade, multidisciplinary research developments have focused upon systemic, genetic, and ocular risk factors of SCR, enabling the clinician to better diagnose and manage these patients. In addition, newer imaging and testing modalities, such as spectral domain-optical coherence tomography angiography, have resulted in the detection of subclinical retinopathy related to SCD. Innovative therapy includes intravitreal injection of an anti-vascular endothelial growth factor (eg, Lucentis® [ranibizumab] or Eylea® [aflibercept]) which appears comparatively safe and efficient, and may be combined with laser photocoagulation (LPC) for proliferative SCR. The effect of LPC alone does not significantly lead to the regression of advanced SCR, although it helps in avoiding hemorrhage and sight loss. This comprehensive article is based on 10-years retrospective (2007–2017) studies. It aims to present advances and recommendations in SCR theranostics while pointing out the requirement of combinatorial approaches for better management of SCR patients. To reach this goal, we identified and analyzed randomized original and review articles, clinical trials, non-randomized intervention studies, and observational studies using specified keywords in various databases (eg, Medline, Embase, Cochrane, ClinicalTrials.gov).

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“…Changes in the nasal halves of the visual fields can also occur in the case of a lesion in the eye region, e.g. when corneal changes such as keratoconus [3] are involved, or retinal changes, sickle-cell anaemia, etc [4].…”

Section: Discussionmentioning

confidence: 99%

Complete Binasal Hemianopsia

Kastner¹

2011

J Clinic Experiment Ophthalmol

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Early in December 2003, the patient experienced subjectively impaired visus. The eye examination revealed increased intraocular pressure. During her hospitalization at the eye clinic, the first scotomas AbstractThe authors describe a case study of a 21-year-old female patient suffering from a tumour in the pineal region and dorsal part of the 3 rd cerebral ventricle (pineocytoma) who developed complete binasal hemianopsia 11 months after the tumour's removal. These perimetric changes did not show any progression for seven years. In discussing the question of the pathogenesis of hemianopic defects, the authors are inclined to the opinion that both of the optic nerves are compressed by the circle of Willis vessels.

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Binasal Visual Field Defects from Simultaneous Bilateral Retinal Infarctions in Sickle Cell Disease

Cited by 18 publications

References 4 publications

Sickle cell retinopathy. A focused review

Sickle cell retinopathy. A focused review

Sickle cell retinopathy: improving care with a multidisciplinary approach

Complete Binasal Hemianopsia

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