Binational burden of American cutaneous leishmaniasis in Oiapoque, Amapá State, Brazil, bordering French Guiana

Santos, Thiago Vasconcelos dos; Chaves, Raimunda Cleide Gonçalves; Prévot, Ghislaine; Sílveira, Fernando Tobias; Póvoa, Marinete Marins; Rangel, Elizabeth Ferreira

doi:10.1590/0037-8682-0256-2018

Cited by 7 publications

(12 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This information, collected on the importance of the influence of human activities in increasing the risk of this disease, as well as the numerous studies carried out on the possible anthropisation of the vector cycle as shown in Colombia [34] and Manaus, Brazil [63], suggest that human activities in the rainforest in the Amazon and French Guiana could promote a peri-domestication of the CL disease cycle. Also, throughout Amazonia, people could be infected in peri-urban forest fragments with great canopy cover, which is essential for maintenance of the Leishmania vector/reservoir species diversity and abundance [64–66].…”

Section: Discussionmentioning

confidence: 99%

Ecological niche modelling for predicting the risk of cutaneous leishmaniasis in the Neotropical moist forest biome

et al. 2019

Self Cite

View full text Add to dashboard Cite

A major challenge of eco-epidemiology is to determine which factors promote the transmission of infectious diseases and to establish risk maps that can be used by public health authorities. The geographic predictions resulting from ecological niche modelling have been widely used for modelling the future dispersion of vectors based on the occurrence records and the potential prevalence of the disease. The establishment of risk maps for disease systems with complex cycles such as cutaneous leishmaniasis (CL) can be very challenging due to the many inference networks between large sets of host and vector species, with considerable heterogeneity in disease patterns in space and time. One novelty in the present study is the use of human CL cases to predict the risk of leishmaniasis occurrence in response to anthropogenic, climatic and environmental factors at two different scales, in the Neotropical moist forest biome (Amazonian basin and surrounding forest ecosystems) and in the surrounding region of French Guiana. With a consistent data set never used before and a conceptual and methodological framework for interpreting data cases, we obtained risk maps with high statistical support. The predominantly identified human CL risk areas are those where the human impact on the environment is significant, associated with less contributory climatic and ecological factors. For both models this study highlights the importance of considering the anthropogenic drivers for disease risk assessment in human, although CL is mainly linked to the sylvatic and peri-urban cycle in Meso and South America.

show abstract

Section: Discussionmentioning

confidence: 99%

Ecological niche modelling for predicting the risk of cutaneous leishmaniasis in the Neotropical moist forest biome

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

“…The municipality of Oiapoque (03°49'29"N, 51°49'05"W) is the most important Brazilian socioeconomic link with the bordering Ultramarine Department of French Guiana. ACL is endemic in this region and is regarded as a “bi-national” issue, asapproximately half of cases appear to be acquired on the Brazilian side, and half on the French Guianan side [9]. Two environments were selected to be surveyed, as follows:…”

Section: Methodsmentioning

confidence: 99%

“…braziliensis is considered an emerging cause of ACL; reported to be linked to forest encroachment associated with the gold-mining industry [8]. Epidemiological data on the clinical profile of ACL patients in the Brazilian region revealed sporadic mucosal commitment presumed to be caused by this parasite species, drawing attention to a worrisome public health issue [9].…”

Section: Introductionmentioning

confidence: 99%

Leishmania DNA detection and species characterization within phlebotomines (Diptera: Psychodidae) from a peridomicile-forest gradient in an Amazonian/Guianan bordering area

et al. 2019

Self Cite

View full text Add to dashboard Cite

In the border region between Brazil and French Guiana, American cutaneous leishmaniasis is a worrisome public health issue, and entomological studies are required there to better identify classical and putative emerging transmission patterns. The present study aimed to detect and characterize Leishmania DNA in the phlebotomine population of Oiapoque (Amapá State, Brazil). Phlebotomines were captured in anthropized and wild environments in the outskirts of Oiapoque municipality, using CDC light traps installed in vertical (ground/canopy level) and horizontal (peridomicile/extradomicile/forest-edge/forest) strata. Captured specimens were identified according to their morphology. Females were processed for Leishmania DNA detection and characterization using a multiplex polymerase chain reaction targeting kinetoplast DNA (kDNA) and the phlebotomine cacophony gene. The kDNA positive samples were characterized by cloning and sequencing the Leishmania 234 bp- hsp70 gene. Among the 3957 phlebotomine specimens captured, 26 pooled female samples were positive for Leishmania ( Viannia ) spp. DNA. Sequencing analysis allowed species-specific identification of L . ( V .) braziliensis DNA in Trichophoromyia ininii , Bichromomyia flaviscutellata , Nyssomyia umbratilis , and Evandromyia infraspinosa , and L . ( V .) guyanensis DNA in Ny . umbratilis . A pooled sample of Ny . umbratilis was positive for both L . ( V .) braziliensis and L . ( V .) guyanensis DNA. The present study provided additional information regarding ACL ecology in Oiapoque, highlighting the presence of L . ( V .) braziliensis DNA in different phlebotomine species. The epidemiological implications of these findings and the determinant incrimination of L . ( V .) braziliensis as proven vectors in that region must be clarified. In this regard, studies on Leishmania spp. infection and suggestive anthropophilic behavior of associated phlebotomines need to be prioritized in entomological surveillance.

show abstract

“…A decrease in rainfall during the dry season has been linked to an increase in CL cases two months later, possibly due to frequent forest activities during the dry months. [10] Only three CL outbreaks have been described in French Guiana so far. Two occurred in military personnel in 1998 [11] and 2002 [12] and a third one in scientists infected with L. braziliensis during a forest trip [13].…”

Section: Introductionmentioning

confidence: 99%

Outbreak of Cutaneous Leishmaniasis among military personnel in French Guiana, 2020: Clinical, phylogenetic, individual and environmental aspects

et al. 2021

Self Cite

View full text Add to dashboard Cite

Background Cutaneous Leishmaniasis (CL) is endemic in French Guiana but cases are usually sporadic. An outbreak signal was issued on May 15th 2020 with 15 suspected cases after a military training course in the rainforest. An outbreak investigation was carried out. Methodology/Principal findings Thirty cases were confirmed. Leishmania guyanensis was the most frequent species (90%). The most frequent presentation was ulcerative (90%). Lesions on the face and hands were frequent (40% each). Eight cases (26%) presented a poor outcome after treatment with pentamidine and required a second line with amphotericin B. Three of them required further treatments with meglumine antimoniate or miltefosine. Two spots within the training area were deemed as likely sites of contamination, due to illegal logging. The isolated Leishmania strains did not form a separate cluster. Participation in Week 13 of year 2020 was associated with infection (OR = 4.59 [1.10–19.83]; p = 0.016) while undergoing only the “Fighting” exercise was protective (OR = 0.1 [0–0.74]; p = 0.021). There was no association between infection and other risk factors at the individual level. The attack rate of Regiment B (14/105 = 13.3%) was significantly higher (OR = 4.22 [1.84–9.53], p = 0.0001) compared to Regiment A (16/507 = 3.2%). The attack rate during this training course (30/858 = 3.5%) was significantly higher (OR 2.29 [1.28–4.13]; p = 0.002) than for other missions in French Guiana during the same period (22/1427 = 1.5%). Conclusions This outbreak could be explained by a combination of factors: climatic conditions around week 13, at-risk activities including night trainings, absence of impregnation, a lesser experience of rainforest duties in Regiment B and illegal logging attracting sandflies on military training grounds.

show abstract

Binational burden of American cutaneous leishmaniasis in Oiapoque, Amapá State, Brazil, bordering French Guiana

Cited by 7 publications

References 10 publications

Ecological niche modelling for predicting the risk of cutaneous leishmaniasis in the Neotropical moist forest biome

Ecological niche modelling for predicting the risk of cutaneous leishmaniasis in the Neotropical moist forest biome

Leishmania DNA detection and species characterization within phlebotomines (Diptera: Psychodidae) from a peridomicile-forest gradient in an Amazonian/Guianan bordering area

Outbreak of Cutaneous Leishmaniasis among military personnel in French Guiana, 2020: Clinical, phylogenetic, individual and environmental aspects

Contact Info

Product

Resources

About