Binding, Antioxidant and Anti-proliferative Properties of Bioactive Compounds of Sweet Paprika (Capsicum annuum L.)

Kim, Hong Gi; Bae, Jong Hyang; Jastrzębski, Zenon; Cherkas, Andriy; Heo, Buk-Gu; Gorinstein, Shela; Ku, Yang Gyu

doi:10.1007/s11130-016-0550-9

Cited by 34 publications

(20 citation statements)

References 27 publications

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“…Moreover, redox modulating agents that have some health benefits when supplemented often turn out to be rather prooxidant than antioxidant, and lead to the stimulation of endogenous antioxidant defenses and the improvement of glucose metabolism. Therapeutic approaches to applying antioxidant substances in order to reduce oxidative damage and the administration of compounds with the pure purpose to provide reducing equivalents appears weak [125] in contrast to often-high in vitro activities [126], and in comparison to existing endogenous antioxidant mechanisms based on glucose as a source of reducing power for the generation of NADPH and recycling oxidized glutathione and thiols, and can in some cases be deleterious since they may interfere with redox sensors-for example protein thiol groups, and cause dysregulations.…”

Section: Limitations Of the Analysis And Directions Of Further Researchmentioning

confidence: 99%

Glucose as a Major Antioxidant: When, What for and Why It Fails?

et al. 2020

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A human organism depends on stable glucose blood levels in order to maintain its metabolic needs. Glucose is considered to be the most important energy source, and glycolysis is postulated as a backbone pathway. However, when the glucose supply is limited, ketone bodies and amino acids can be used to produce enough ATP. In contrast, for the functioning of the pentose phosphate pathway (PPP) glucose is essential and cannot be substituted by other metabolites. The PPP generates and maintains the levels of nicotinamide adenine dinucleotide phosphate (NADPH) needed for the reduction in oxidized glutathione and protein thiols, the synthesis of lipids and DNA as well as for xenobiotic detoxification, regulatory redox signaling and counteracting infections. The flux of glucose into a PPP—particularly under extreme oxidative and toxic challenges—is critical for survival, whereas the glycolytic pathway is primarily activated when glucose is abundant, and there is lack of NADP+ that is required for the activation of glucose-6 phosphate dehydrogenase. An important role of glycogen stores in resistance to oxidative challenges is discussed. Current evidences explain the disruptive metabolic effects and detrimental health consequences of chronic nutritional carbohydrate overload, and provide new insights into the positive metabolic effects of intermittent fasting, caloric restriction, exercise, and ketogenic diet through modulation of redox homeostasis.

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Section: Limitations Of the Analysis And Directions Of Further Researchmentioning

confidence: 99%

Glucose as a Major Antioxidant: When, What for and Why It Fails?

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Moreover, redox modulating agents that have some health benefits when supplemented often turn to be rather prooxidant than antioxidant and lead to stimulation of endogenous antioxidant defense and improvement of glucose metabolism. Besides, therapeutic approaches to apply antioxidant substances in order to reduce oxidative damage and any administration of compounds with pure purpose to provide reducing equivalents appears weak [125] in contrast to often high in vitro activities [126] in comparison to existing endogenous antioxidant mechanisms, based on glucose as a source of reducing power for generation of NADPH and recycling oxidized glutathione and thiols and can in some cases be deleterious since they may interfere with redox sensors, for example protein thiol groups and cause dysregulations.…”

Section: Limitations Of the Analysis And Directions Of Further Researchmentioning

confidence: 99%

Glucose as a Major Antioxidant: When, What for and Why It Fails?

Cherkas¹,

Holota²,

Mdzinarashvili³

et al. 2020

Preprint

Self Cite

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A human organism depends on stable glucose blood levels in order to maintain the metabolic needs. Glucose is considered as the most important energy source and glycolysis is postulated as a backbone pathway. However, when glucose supply is limited, ketone bodies and amino acids can be used to produce enough ATP. In contrast, for the functioning of pentose phosphate pathway (PPP) glucose is essential and cannot be substituted by other metabolites. PPP generates and maintains levels of NADPH needed for reduction of oxidized glutathione and protein thiols, synthesis of lipids and DNA as well as for xenobiotic detoxification, regulatory redox signaling and counteracting infections. Flux of glucose into a PPP, particularly under extreme oxidative and toxic challenges is critical for survival, whereas the glycolytic pathway is primarily activated when glucose is abundant, and there is lack of NADP+ that is required for activation of glucose-6 phosphate dehydrogenase. An important role of glycogen stores in resistance to oxidative challenges is discussed. Current evidences explain disruptive metabolic effects and detrimental health consequences of chronic nutritional carbohydrate overload and provides new insights into positive metabolic effects of intermittent fasting, caloric restriction, exercise, and ketogenic diet through modulation of redox homeostasis.

show abstract

“…Moreover, redox modulating agents that have some health benefits when supplemented often turn to be rather prooxidant than antioxidant and lead to stimulation of endogenous antioxidant defense and improvement of glucose metabolism. Besides, therapeutic approaches to apply antioxidant substances in order to reduce oxidative damage and any administration of compounds with pure purpose to provide reducing equivalents appears weak [109] in contrast to often high in vitro activities [110] in comparison to existing endogenous antioxidant mechanisms, based on glucose as a source of reducing power for generation of NADPH and recycling oxidized glutathione and thiols and can in some cases be deleterious since they may interfere with redox sensors, for example protein thiol groups and cause dysregulations.…”

Section: Limitations Of the Analysis And Directions Of Further Researchmentioning

confidence: 99%

Glucose as a Major Antioxidant: When, What for and Why It Fails?

Cherkas¹,

Holota²,

Mdzinarashvili³

et al. 2019

Preprint

Self Cite

View full text Add to dashboard Cite

A human organism depends on stable glucose blood levels in order to maintain the metabolic needs. Glucose is considered as the most important energy source and glycolysis is postulated as a backbone pathway. However, when glucose supply is limited, ketone bodies and amino acids can be used to produce enough ATP. In contrast, for the functioning of pentose phosphate pathway (PPP) glucose is essential and cannot be substituted for by other metabolites. PPP generates and maintains levels of NADPH needed for reduction of oxidized glutathione and protein thiols, synthesis of lipids and DNA as well as for xenobiotics detoxification, regulatory redox signaling and counteracting infections. Flux of glucose into a PPP, particularly under extreme oxidative and toxic challenges is critical for survival, whereas the glycolytic pathway is primarily activated when glucose is abundant, and there is lack of NADP+ that is required for activation of glucose-6 phosphate dehydrogenase. An important role of glycogen stores in resistance to oxidative challenges is discussed. Current evidence explains disruptive metabolic effects and detrimental health consequences of chronic nutritional carbohydrate overload and provides new insights into positive metabolic effects of intermittent fasting, caloric restriction, exercise, and ketogenic diet through modulation of redox homeostasis.

show abstract

Binding, Antioxidant and Anti-proliferative Properties of Bioactive Compounds of Sweet Paprika (Capsicum annuum L.)

Cited by 34 publications

References 27 publications

Glucose as a Major Antioxidant: When, What for and Why It Fails?

Glucose as a Major Antioxidant: When, What for and Why It Fails?

Glucose as a Major Antioxidant: When, What for and Why It Fails?

Glucose as a Major Antioxidant: When, What for and Why It Fails?

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