Binding Characteristics of Ciliary Neurotrophic Factor to Sympathetic Neurons and Neuronal Cell Lines

Wong, Vivien; Pearsall, Denise; Arriaga, Ruth; Ip, Nancy Y.; Stahl, Neil; Lindsay, Ronald M.

doi:10.1074/jbc.270.1.313

Cited by 27 publications

(21 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, reduced Cntf levels could contribute to this phenotype. Levels of Cntf protein in human peripheral nerves are much lower than in mice (M.S., unpublished observations), and human CNTF is less active than the mouse Cntf protein, even in human target cells (41). Thus, reduced gene expression might be more critical in humans in comparison to mice.…”

Section: Discussionmentioning

confidence: 97%

Sox10 regulates ciliary neurotrophic factor gene expression in Schwann cells

Ito

Wiese

Funk

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 97%

Sox10 regulates ciliary neurotrophic factor gene expression in Schwann cells

Ito

Wiese

Funk

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

“…This subunit is present in intact neurons in the SCG (Wong et al, 1995), DRG (Gardiner et al, 2002), and cranial and spinal motor nuclei (Watanabe et al, 1996). gp130 mRNA does not change after axotomy in SCG (Banner and Patterson, 1994), DRG (Gardiner et al, 2002; Brazda et al, 2009) or facial motor neurons (Haas et al, 1999).…”

Section: Cytokine Receptors In Normal and Axotomized Peripheral Neuronsmentioning

confidence: 99%

gp130 cytokines are positive signals triggering changes in gene expression and axon outgrowth in peripheral neurons following injury

Zigmond¹

2012

Front. Mol. Neurosci.

View full text Add to dashboard Cite

Adult peripheral neurons, in contrast to adult central neurons, are capable of regeneration after axonal damage. Much attention has focused on the changes that accompany this regeneration in two places, the distal nerve segment (where phagocytosis of axonal debris, changes in the surface properties of Schwann cells, and induction of growth factors and cytokines occur) and the neuronal cell body (where dramatic changes in cell morphology and gene expression occur). The changes in the axotomized cell body are often referred to as the “cell body response.” The focus of the current review is a family of cytokines, the glycoprotein 130 (gp130) cytokines, which produce their actions through a common gp130 signaling receptor and which function as injury signals for axotomized peripheral neurons, triggering changes in gene expression and in neurite outgrowth. These cytokines play important roles in the responses of sympathetic, sensory, and motor neurons to injury. The best studied of these cytokines in this context are leukemia inhibitory factor (LIF) and interleukin (IL)-6, but experiments with conditional gp130 knockout animals suggest that other members of this family, not yet determined, are also involved. The primary gp130 signaling pathway shown to be involved is the activation of Janus kinase (JAK) and the transcription factors Signal Transducers and Activators of Transcription (STAT), though other downstream pathways such as mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) may also play a role. gp130 signaling may involve paracrine, retrograde, and autocrine actions of these cytokines. Recent studies suggest that manipulation of this cytokine system can also stimulate regeneration by injured central neurons.

show abstract

“…1996). Another group found that LIF and CNTF treatment of neurons can inhibit subsequent binding of CNTF, providing evidence of reduced receptor surface expression, but they did not examine total receptor levels (Wong et al. 1995).…”

Section: Discussionmentioning

confidence: 99%

Transregulation of leukemia inhibitor factor receptor expression and function by growth factors in neuroblastoma cells

Port

Laszlo

Nathanson

2008

Journal of Neurochemistry

View full text Add to dashboard Cite

The cytokines that signal through the leukemia inhibitory factor (LIF) receptor are members of the neuropoietic cytokine family and have varied and numerous roles in the nervous system. In this report we have determined the effects of growth factor stimulation on LIF receptor (LIFR) expression and signal transduction in the human neuroblastoma cell line NBFL. We show here that stimulation of NBFL cells with either epidermal growth factor or fibroblast growth factor decreases the level of LIFR in an extracellular signal-regulated kinase (Erk)1/2-dependent manner and that this downregulation is due to an increase in the apparent rate of lysosomal LIFR degradation. Growth factor-induced decreases in LIFR level inhibit both LIF-stimulated phosphorylation of signal transducers and activators of transcription 3 (STAT3) and LIFRmediated gene induction. We also show that Ser1044 of LIFR, which we have previously shown to be phosphorylated by Erk1/2, is required for the inhibitory effects of growth factors. Neurons are exposed to varying combinations and concentrations of growth factors and cytokines that influence their growth, development, differentiation and repair in vivo. These findings demonstrate that LIFR expression and signaling in neuroblastoma cells can be regulated by growth factors that are potent activators of the mitogen activated protein kinase pathway, and thus illustrate a fundamental mechanism that underlies cross-talk between receptor tyrosine kinase and neuropoietic cytokine signaling pathways. Keywords leukemia inhibitory factor; gp130; growth factor; MAP Kinase; cytokine The leukemia inhibitory factor receptor (LIFR), together with glycoprotein 130 (gp130), acts as a signal transducing receptor for a group of related cytokines that include leukemia Address correspondence to: Neil M. Nathanson, Department of Pharmacology, University of Washington, Box 357750, 1959 NE Pacific, Seattle, WA, 98195-7750, Tel. 206-543-9457; Fax. 206-616-4230; E-mail: nathanso@u.washington 1 The abbreviations used in the text are: CaMK, Ca 2+ /calmodulin-dependent kinase; CLC, cardiotrophin-like cytokine; CNTF, ciliary neurotrophic factor; CNTFR, ciliary neurotrophic factor receptor; CT-1, cardiotrophin-1; DMEM, Dulbecco's modified Eagle's medium; DMSO, dimethyl sulfoxide; DTT, dithriotreithol; EGF, epithelial growth factor; ERK, extracellular signal-regulated kinase; FBS, fetal bovine serum; FGF, fibroblast growth factor; G-CSF, granulocyte colony stimulating factor; G-CSFR, G-SCF receptor; gp130, glycoprotein 130; IL, interleukin; JAK, Janus kinase; LIF, leukemia inhibitory factor; LIFR, leukemia inhibitory factor receptor; MAPK, mitogen activated protein kinase; MEK, MAPK kinase; NGF, nerve growth factor; OsM, Oncostatin M; PERK, phosphorylated ERK; PAGE, polyacrylamide gel electrophoresis; PBS, phosphate-buffered saline; PIAS, protein induced by activated STATs; PMA, phorbol 12-myristate 13-acetate; PY-STAT3, Tyr705-phosphorylated STAT3; SDS, sodium dodecyl sulphate; SHP, src homology 2 domain-containing phos...

show abstract

Binding Characteristics of Ciliary Neurotrophic Factor to Sympathetic Neurons and Neuronal Cell Lines

Cited by 27 publications

References 46 publications

Sox10 regulates ciliary neurotrophic factor gene expression in Schwann cells

Sox10 regulates ciliary neurotrophic factor gene expression in Schwann cells

gp130 cytokines are positive signals triggering changes in gene expression and axon outgrowth in peripheral neurons following injury

Transregulation of leukemia inhibitor factor receptor expression and function by growth factors in neuroblastoma cells

Contact Info

Product

Resources

About