Binding efficacy and kinetics of chitosan with DNA duplex: The effects of deacetylation degree and nucleotide sequences

Yang, Yanmei; Guo, Meng; Qu, Rui; Liu, Chang; Zong, Xumin; Li, Yongqiang; Liu, Weifeng

doi:10.1016/j.carbpol.2017.04.040

Cited by 16 publications

(8 citation statements)

References 42 publications

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“…The degree of deacetylation (DD) determines the positive charge and solubility of chitosan, the binding capacity of gene, cellular uptake and finally the transfection efficiency [16,31]. Higher DD translates to more primary amines in a chitosan molecule, increased positive charge and eventually higher capacity of gene complexation.…”

Section: Design Criteria and Requirements For Gene Delivery Using mentioning

confidence: 99%

Recent Advances in Chitosan-Based Carriers for Gene Delivery

et al. 2019

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Approximately 4000 diseases are associated with malfunctioning genes in a particular cell type. Gene-based therapy provides a platform to modify the disease-causing genes expression at the cellular level to treat pathological conditions. However, gene delivery is challenging as these therapeutic genes need to overcome several physiological and intracellular barriers in order, to reach the target cells. Over the years, efforts have been dedicated to develop efficient gene delivery vectors to overcome these systemic barriers. Chitosan, a versatile polysaccharide, is an attractive non-viral vector material for gene delivery mainly due to its cationic nature, biodegradability and biocompatibility. The present review discusses the design factors that are critical for efficient gene delivery/transfection and highlights the recent progress of gene therapy using chitosan-based carriers.

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Section: Design Criteria and Requirements For Gene Delivery Using mentioning

confidence: 99%

Recent Advances in Chitosan-Based Carriers for Gene Delivery

et al. 2019

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“…In comparison to the AHM, CCAHM results in higher removal efficiency of the genetic material, possibly, chitosan also have ability to conjugate with the genetic material. 58 In bio-fouling evaluation, the membrane performance is typically evaluated in terms of water ux and bacteria ux during cyclic ltration tests. The biolm formation directly inuences the ow rate of the membrane.…”

Section: Resultsmentioning

confidence: 99%

Amyloid hybrid membranes for bacterial & genetic material removal from water and their anti-biofouling properties

et al. 2020

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“…It has been reported that chitosan has broad-spectrum antimicrobial activity and can inhibit the growth of many kinds of bacteria, fungi, and yeast [ 8 , 9 ]. It can combine with the cell wall of microorganisms, inhibit the replication of DNA, and be used as a potential source of new biocides [ 10 , 11 ]. Therefore, in recent years, the application of chitosan in medicine, agriculture, food, textile and other fields has attracted much attention [ 12 , 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Design of Chitosan Sterilization Agents by a Structure Combination Strategy and Their Potential Application in Crop Protection

Liu

Qin

2021

Molecules

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Chitosan is the only cationic polysaccharide in nature. It is a type of renewable resource and is abundant. It has good biocompatibility, biodegradability and biological activity. The amino and hydroxyl groups in its molecules can be modified, which enables chitosan to contain a variety of functional groups, giving it a variety of properties. In recent years, researchers have used different strategies to synthesize a variety of chitosan derivatives with novel structure and unique activity. Structure combination is one of the main strategies. Therefore, we will evaluate the synthesis and agricultural antimicrobial applications of the active chitosan derivatives structure combinations, which have not been well-summarized. In addition, the advantages, challenges and developmental prospects of agricultural antimicrobial chitosan derivatives will be discussed.

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Binding efficacy and kinetics of chitosan with DNA duplex: The effects of deacetylation degree and nucleotide sequences

Cited by 16 publications

References 42 publications

Recent Advances in Chitosan-Based Carriers for Gene Delivery

Recent Advances in Chitosan-Based Carriers for Gene Delivery

Amyloid hybrid membranes for bacterial & genetic material removal from water and their anti-biofouling properties

Design of Chitosan Sterilization Agents by a Structure Combination Strategy and Their Potential Application in Crop Protection

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