Binding-induced fibrillogenesis peptide inhibits RANKL-mediated osteoclast activation against osteoporosis

Liang, Qi-Lin; Xu, Huan-Ge; Yu, Long; Ding, Meng-Ru; Li, Yu-Ting; Qi, Gao-Feng; Zhang, Kuo; Wang, Lei; Wang, Hao; Cui, Xu

doi:10.1016/j.biomaterials.2023.122331

Cited by 7 publications

(3 citation statements)

References 55 publications

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“…S11 a). Furthermore, a quantitative real-time polymerase chain reaction (qRT-PCR) assay was chosen to determine the expression of osteoclast related genes like bone resorption enzyme (matrix metalloproteinase 9, MMP9) and osteoclast transcription factor (nuclear factor of activated T cells 1, Nfatc1) [ 37 ]. According to Fig.…”

Section: Resultsmentioning

confidence: 99%

Inflammatory microenvironment regulation and osteogenesis promotion by bone-targeting calcium and magnesium repletion nanoplatform for osteoporosis therapy

Weng,

Ye,

Cai

et al. 2024

J Nanobiotechnol

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Osteoporosis is the most common bone metabolic disease that affects the health of middle-aged and elderly people, which is hallmarked by imbalanced bone remodeling and a deteriorating immune microenvironment. Magnesium and calcium are pivotal matrix components that participate in the bone formation process, especially in the immune microenvironment regulation and bone remodeling stages. Nevertheless, how to potently deliver magnesium and calcium to bone tissue remains a challenge. Here, we have constructed a multifunctional nanoplatform composed of calcium-based upconversion nanoparticles and magnesium organic frameworks (CM-NH2-PAA-Ald, denoted as CMPA), which features bone-targeting and pH-responsive properties, effectively regulating the inflammatory microenvironment and promoting the coordination of osteogenic functions for treating osteoporosis. The nanoplatform can efficaciously target bone tissue and gradually degrade in response to the acidic microenvironment of osteoporosis to release magnesium and calcium ions. This study validates that CMPA possessing favorable biocompatibility can suppress inflammation and facilitate osteogenesis to treat osteoporosis. Importantly, high-throughput sequencing results demonstrate that the nanoplatform exerts a good inflammatory regulation effect through inhibition of the nuclear factor kappa-B signaling pathway, thereby normalizing the osteoporotic microenvironment. This collaborative therapeutic strategy that focuses on improving bone microenvironment and promoting osteogenesis provides new insight for the treatment of metabolic diseases such as osteoporosis.

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Section: Resultsmentioning

confidence: 99%

Inflammatory microenvironment regulation and osteogenesis promotion by bone-targeting calcium and magnesium repletion nanoplatform for osteoporosis therapy

Weng,

Ye,

Cai

et al. 2024

J Nanobiotechnol

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“…Osteoimmunology has received extensive attention over the past 20 years. Several innate immune cells have emerged as key regulators of osteoporosis by producing proinflammatory mediators and modulating the TLR4/NF-κB as well as the RANK/RANKL axis ( 114 ). Since the immune system and the skeletal system share a wide variety of molecules (i.e., cytokines, chemokines, hormones, receptors, and transcription factors) and the close interaction between osteoblasts and immune cells ( 115 ), future immunotherapy-targeted TLR4 may provide a promising therapeutic direction against osteoporosis.…”

Section: Future Perspectivesmentioning

confidence: 99%

The critical role of toll-like receptor 4 in bone remodeling of osteoporosis: from inflammation recognition to immunity

Zhu,

Du,

Zhang

et al. 2024

Front. Immunol.

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Osteoporosis is a common chronic metabolic bone disorder. Recently, increasing numbers of studies have demonstrated that Toll-like receptor 4 (TLR4, a receptor located on the surface of osteoclasts and osteoblasts) plays a pivotal role in the development of osteoporosis. Herein, we performed a comprehensive review to summarize the findings from the relevant studies within this topic. Clinical data showed that TLR4 polymorphisms and aberrant TLR4 expression have been associated with the clinical significance of osteoporosis. Mechanistically, dysregulation of osteoblasts and osteoclasts induced by abnormal expression of TLR4 is the main molecular mechanism underlying the pathological processes of osteoporosis, which may be associated with the interactions between TLR4 and NF-κB pathway, proinflammatory effects, ncRNAs, and RUNX2. In vivo and in vitro studies demonstrate that many promising substances or agents (i.e., methionine, dioscin, miR-1906 mimic, artesunate, AEG-1 deletion, patchouli alcohol, and Bacteroides vulgatus) have been able to improve bone metabolism (i.e., inhibits bone resorption and promotes bone formation), which may partially attribute to the inhibition of TLR4 expression. The present review highlights the important role of TLR4 in the clinical significance and the pathogenesis of osteoporosis from the aspects of inflammation and immunity. Future therapeutic strategies targeting TLR4 may provide a new insight for osteoporosis treatment.

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“…Increasingly, studies are showing that bone health is largely influenced by the regulation of redox balance, with the control of ROS production in bone cells emerging as a critical strategy for preventing bone deterioration ( Kaur et al, 2021 ). The activation of osteoclasts by receptor activator of NF-κB ligand (RANKL) through binding to RANK receptors on the surface of osteoclasts induces the formation of multinucleated giant cells, subsequently facilitating bone resorption and remodeling ( Liang et al, 2023 ). The interaction between RANKL and ROS plays a key role in osteoclast activation and bone remodeling, forming a positive feedback loop to influence bone metabolic homeostasis ( Tanaka et al, 2023 ; Xu et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Elucidating causal relationships of diet-derived circulating antioxidants and the risk of osteoporosis: A Mendelian randomization study

Yuan,

Xie,

Huang

et al. 2024

Front. Genet.

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BackgroundOsteoporosis (OP) is typically diagnosed by evaluating bone mineral density (BMD), and it frequently results in fractures. Here, we investigated the causal relationships between diet-derived circulating antioxidants and the risk of OP using Mendelian randomization (MR).MethodsPublished studies were used to identify instrumental variables related to absolute levels of circulating antioxidants like lycopene, retinol, ascorbate, and β-carotene, as well as antioxidant metabolites such as ascorbate, retinol, α-tocopherol, and γ-tocopherol. Outcome variables included BMD (in femoral neck, lumbar spine, forearm, heel, total body, total body (age over 60), total body (age 45–60), total body (age 30–45), total body (age 15–30), and total body (age 0–15)), fractures (in arm, spine, leg, heel, and osteoporotic fractures), and OP. Inverse variance weighted or Wald ratio was chosen as the main method for MR analysis based on the number of single nucleotide polymorphisms (SNPs). Furthermore, we performed sensitivity analyses to confirm the reliability of the findings.ResultsWe found a causal relationship between absolute retinol levels and heel BMD (p = 7.6E-05). The results of fixed effects IVW showed a protective effect of absolute retinol levels against heel BMD, with per 0.1 ln-transformed retinol being associated with a 28% increase in heel BMD (OR: 1.28, 95% CI: 1.13–1.44). In addition, a sex-specific effect of the absolute circulating retinol levels on the heel BMD has been observed in men. No other significant causal relationship was found.ConclusionThere is a positive causal relationship between absolute retinol levels and heel BMD. The implications of our results should be taken into account in future studies and in the creation of public health policies and OP prevention tactics.

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Binding-induced fibrillogenesis peptide inhibits RANKL-mediated osteoclast activation against osteoporosis

Cited by 7 publications

References 55 publications

Inflammatory microenvironment regulation and osteogenesis promotion by bone-targeting calcium and magnesium repletion nanoplatform for osteoporosis therapy

Inflammatory microenvironment regulation and osteogenesis promotion by bone-targeting calcium and magnesium repletion nanoplatform for osteoporosis therapy

The critical role of toll-like receptor 4 in bone remodeling of osteoporosis: from inflammation recognition to immunity

Elucidating causal relationships of diet-derived circulating antioxidants and the risk of osteoporosis: A Mendelian randomization study

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