Binding Interactions Between Tetracaine Hydrochloride and Biocompatible Imidazolium-Based Gemini Surfactants in Aqueous Solutions

Mir, Ab Waheed; Shaheen, Arifa; Arif, Rabia; Dar, Muzammil Sharief

doi:10.1007/s10953-021-01073-8

Cited by 5 publications

(3 citation statements)

References 39 publications

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“…It is also observed that the CMC values of these mixed systems increase for higher values of α PMZ, which may be related to the increasing surface charge density in mixed micelles (Figures 1a and 2a). [28] It is also observed that the CMC values of pure and mixed systems (Tables 1 and 2) increase as temperature rises (Figure 1b, 2b), which may be caused by disruption of structured water around hydrophobic groups, resulting in delayed micelle formation and hence a higher CMC value (Figure S3, S4) [28] . The CMC values for PMZ‐[Cho][Doc] are lower than PMZ‐[Cho][Sar] at all mole fractions of PMZ due to higher [Doc] surface area and its less structural flexibility, which enable and support the greater interaction between drug and [Cho][Doc] SAIL [29] …”

Section: Resultsmentioning

confidence: 99%

Mixed Micellization of Promazine Hydrochloride with Cholinium‐Based Anionic Surface Active Ionic Liquids and their Potential Application for the Synthesis of Silver Nanoparticles

Arif,

Dhanagar,

Shaheen

2023

ChemistrySelect

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This work is aimed to study the interaction of an amphiphilic drug, promazine hydrochloride (PMZ) and two anionic surface active ionic liquids (SAILs), cholinium laurylsarcosinate [Cho][Sar] and cholinium deoxycholate [Cho][Doc] using conductivity, UV‐visible spectroscopy and fluorescence techniques. The results obtained by all three techniques indicated non‐ideal behavior and synergistic interactions between the PMZ drug and SAIL mixed systems. Further, the drug‐SAIL mixtures were used to stabilize silver nanoparticles (Ag NPs) in aqueous solution. The results of UV‐visible spectroscopy, dynamic light scattering (DLS) and transmission electron microscopy (TEM) showed that PMZ and SAILs had strong electrostatic and hydrophobic interactions which played a significant role in the stabilization of Ag NPs. The morphological analysis of the Ag NPs showed the formation of various types of aggregates controlled by the internal packing of PMZ‐[Cho][Sar]/[Cho][Doc] mixed systems. These drug‐SAIL based NPs could be used in separation and synthesis applications in nanotechnology by altering the structure of drugs and SAILs.

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Section: Resultsmentioning

confidence: 99%

Mixed Micellization of Promazine Hydrochloride with Cholinium‐Based Anionic Surface Active Ionic Liquids and their Potential Application for the Synthesis of Silver Nanoparticles

Arif,

Dhanagar,

Shaheen

2023

ChemistrySelect

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“…Two absorption peaks (at 226 and 310 nm) were seen on the UV-visible spectra of a drug (TCH). The first peak at 226 nm may be due to the π–π* and the second one (310 nm) due to the n–π* transitions [ 32 , 58 ]. It is worth explaining here that the surfactants did not show any peak in the UV-visible spectrum.…”

Section: Uv-visible Study Of the Mixed Systemmentioning

confidence: 99%

“…Due to the presence of dual characters such as a surfactant molecule they are also associated with small, organized aggregates known as a micelle. The TCH and gemini mixtures not only show synergism but also give antibacterial activity against gram-positive bacteria [ 32 ]. Thus, these mixtures may offer advancements in biomedical and pharmaceutical fields.…”

Section: Introductionmentioning

confidence: 99%

Mixed Micellization, Thermodynamic and Adsorption Behavior of Tetracaine Hydrochloride in the Presence of Cationic Gemini/Conventional Surfactants

Azum

Rub

Khan

et al. 2022

Gels

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In this approach, tensiometry and UV-visible techniques are used to determine the effect of cationic gemini and conventional surfactants on tetracaine hydrochloride (TCH), an anesthetic drug. We have estimated micellar, interfacial, and energetic constraints. To gain a deep understanding of their mixed association behavior, the outputs were examined using different theoretical models. The critical micelle concentration for single and mixed amphiphiles was estimated. The cmc values of mixed amphiphiles were found between the individual amphiphiles due to strong attractive interaction (synergism) between the components after mixing. The non-ideal behavior of mixtures was confirmed by the larger values of ideal cmc than the experimental cmc values. The negative values of interaction parameter (β) and values of activity coefficients less than unity indicate strong synergistic interaction between drug and surfactant. The stability of the mixed systems is demonstrated by the negative Gibbs free energy of micellization and excess free energy of micellization. In contrast to a single chain surfactant, a double chain surfactant (gemini) exhibits better interactions with the drug. Spectral measurements (UV-visible spectra) were used to monitor the binding of the drug with surfactant (conventional as well as gemini). Studying these mixed aggregates could help to optimize their compositions and find synergistic properties between TCH monomers and surfactants.

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Interaction of drug molecules with surfactants below (Benesi-Hildebrand equation) and above the critical micelle concentration (Kawamura equation)

Agatić,

Tepavčević,

Puača

et al. 2024

International Journal of Pharmaceutics

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Binding Interactions Between Tetracaine Hydrochloride and Biocompatible Imidazolium-Based Gemini Surfactants in Aqueous Solutions

Cited by 5 publications

References 39 publications

Mixed Micellization of Promazine Hydrochloride with Cholinium‐Based Anionic Surface Active Ionic Liquids and their Potential Application for the Synthesis of Silver Nanoparticles

Mixed Micellization of Promazine Hydrochloride with Cholinium‐Based Anionic Surface Active Ionic Liquids and their Potential Application for the Synthesis of Silver Nanoparticles

Mixed Micellization, Thermodynamic and Adsorption Behavior of Tetracaine Hydrochloride in the Presence of Cationic Gemini/Conventional Surfactants

Interaction of drug molecules with surfactants below (Benesi-Hildebrand equation) and above the critical micelle concentration (Kawamura equation)

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