Binding modes of high stoichiometry guest complexes with a Co₈L₁₂ cage uncovered by mass spectrometry

Abstract

Internal and external binding modes of guests with a Co8L12 cage were uncovered by mass spectrometry.

Multipocket Cage Enables the Binding of High-Order Bulky and Drug Guests Uncovered by MS Methodology

“…makes it unexplicit to interpret nonspecific and differential multiguest-binding events, let alone fast guest exchange, broad line widths, and very short relaxation times often encountered in supramolecular systems, − which sometimes are less informative and even cause misleading conclusions. ,, Therefore, research into methodologies capable of directly providing binding information for high-order and heteroguest systems is of demanding interest. Mass spectrometry, with advantages of minimal sample consumption, rapid analysis, high sensitivity and resolution, and individual species identification, as well as well-developed techniques, provides another vivid characterization option, emerging as a valuable analytic tool not only suitable for studying high-stoichiometry guest-binding and distinct binding modes but also applicable to understanding the dynamic solution process free from solvent competition and heteroguest interference, ,,− albeit with the cautions of ionization and desolvation conditions in the gas phase.…”