2020
DOI: 10.1016/j.bbamem.2020.183291
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Binding of an antimicrobial peptide to bacterial cells: Interaction with different species, strains and cellular components

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Cited by 74 publications
(101 citation statements)
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“…values, according to the model, an estimate for the threshold of bound peptide molecules per cell needed for bacterial killing can be obtained (i.e., ; Table 3), which determines the strength of the IE, since it defines the slope of the curve (Equations 2 and 3). These values ranged from millions to billions of molecules per cell, confirming our previous conclusion that a huge accumulation of peptide on each cell is required to achieve an antibacterial effect [Roversi 2014, Savini 2017, Savini 2018, Savini 2020. These numbers are in agreement also with the few previously reported data for the threshold of bound AMP molecules needed for bacterial killing [Steiner 1988, Tran 2002, Roversi 2014, Starr 2016, Savini 2020, which all are within the range of 10 6 -10 8 molecules/cell (for a review of these data, see [Savini 2018]).…”
Section: Wheresupporting
confidence: 89%
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“…values, according to the model, an estimate for the threshold of bound peptide molecules per cell needed for bacterial killing can be obtained (i.e., ; Table 3), which determines the strength of the IE, since it defines the slope of the curve (Equations 2 and 3). These values ranged from millions to billions of molecules per cell, confirming our previous conclusion that a huge accumulation of peptide on each cell is required to achieve an antibacterial effect [Roversi 2014, Savini 2017, Savini 2018, Savini 2020. These numbers are in agreement also with the few previously reported data for the threshold of bound AMP molecules needed for bacterial killing [Steiner 1988, Tran 2002, Roversi 2014, Starr 2016, Savini 2020, which all are within the range of 10 6 -10 8 molecules/cell (for a review of these data, see [Savini 2018]).…”
Section: Wheresupporting
confidence: 89%
“…These values ranged from millions to billions of molecules per cell, confirming our previous conclusion that a huge accumulation of peptide on each cell is required to achieve an antibacterial effect [Roversi 2014, Savini 2017, Savini 2018, Savini 2020. These numbers are in agreement also with the few previously reported data for the threshold of bound AMP molecules needed for bacterial killing [Steiner 1988, Tran 2002, Roversi 2014, Starr 2016, Savini 2020, which all are within the range of 10 6 -10 8 molecules/cell (for a review of these data, see [Savini 2018]). However, simple calculations indicate that these numbers correspond to a complete coverage of all the bacterial membranes, or even exceed this limit [Roversi 2014, Savini 2017, Savini 2020.…”
Section: Wheresupporting
confidence: 89%
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“…In recent study using a synthetic and naturally occurring peptide, ‘ARVA’ and PMAP-23, respectively, it was determined that ~107 peptide molecules/cell is required for complete killing (40, 41). However, not all peptides are affected equally by the presence of host cells like RBCs (39, 42). In the crowded environment like gut, microbial population density is much higher than the host cells (43).…”
Section: Resultsmentioning
confidence: 99%