Binding of an Antiviral Agent (Kethoxal) by Various Metabolites

Antiviral Activity of Glyoxals and Derivatives

“…The reaction mixture was heated for an additional 30 min., cooled, and the solid was separated by filtration and washed thoroughly with cold ethanol to give 34 g. (43%) of product. Characteristic infrared bands, 2.95 (-NH), 6.0 (-C=0), 9.5 (ethoxy), and 10.5 µ (acid).…”

“…and then slurried with ether to give 17 g. (100%) of pale yellow solid. Characteristic infrared bands, 5.95 (-C=0), 6.05 (-C=X-), and 10.6 µ (acid).…”

“…The mixture was cooled and the solid separated by filtration and washed with ether to give 19 g. (92%) of pale yellow solid. Characteristic infrared bands, Xi)'"xo1 5.98 (-C=0), 6.05 (-C=N-), and 10.7 µ (acid).…”

“…For the preparation of [ethylenebis-(oxyethy lene)]bis ¡dimethyl [l-methyl-3-(2,2,6-trimethylcyclohexyl)propyl] I ammonium chloride (Table IV, 20), l,2-bis-(2-iodoethoxy (ethane was used as the starting material. The latter w-as prepared from the commercially available l,2-bis(2-chloroethoxy(ethane ("triglycol dichloride") by treatment with sodium iodide in acetone.30 N,N 6,propyl]-N,N'-dimethyI-l,3-propanediamine Bis(methobromide) Dihydrate. Method E.-Compound 2 (Table III) is described as a representative example.…”

“…Method E.-Compound 2 (Table III) is described as a representative example. 6,propyl] dimethylamine (13.4 g., 0.06 mole) (Table I, 2) and 6.1 g. (0.03 mole) of 1,3-dibromopropane was dissolved in 150 ml. of ethanol and refluxed for 72 hr.…”