Binding of benzo(a)pyrene metabolite(s) to main and satellite calf thymus DNA's <i>in vitro</i>

Meunier, Michèle; Chauveau, J

doi:10.1016/0014-5793(73)80133-4

Cited by 6 publications

(1 citation statement)

References 12 publications

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“…This interest is manifested by numerous metabolic studies of BP both in vivo (3-9) and in vitro (10-17), the testing of BP and its metabolites for their carcinogenic and mutagenic potency (18,19), and binding studies of BP and its metabolites to nucleic acids and polynucleotides (15,(20)(21)(22)(23). The growing evidence that arene oxides are ultimate carcinogens of polycyclic aromatic hydrocarbons (24,25), and the established intermediacy of arene oxides in the metabolism of several of these hydrocarbons (26)(27)(28)(29), make a critical examination of the metabolism of BP imperative.…”

Section: Introductionmentioning

confidence: 99%

Effects of Inducers and Epoxide Hydrase on the Metabolism of Benzo[ a ]pyrene by Liver Microsomes and a Reconstituted System: Analysis by High Pressure Liquid Chromatography

Holder

Yagi

Dansette

et al. 1974

Proc. Natl. Acad. Sci. U.S.A.

172

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The mobilities of 24 potential metabolites of benzo [a] The widespread occurrence of benzo[a]pyrene (BP) as an environmental contaminant (1) and the carcinogenic effects of BP in experimental animals (2) have stimulated interest in this compound for some 40 years. This interest is manifested by numerous metabolic studies of BP both in vivo (3-9) and in vitro (10-17), the testing of BP and its metabolites for their carcinogenic and mutagenic potency (18,19), and binding studies of BP and its metabolites to nucleic acids and polynucleotides (15,(20)(21)(22)(23). The growing evidence that arene oxides are ultimate carcinogens of polycyclic aromatic hydrocarbons (24,25), and the established intermediacy of arene oxides in the metabolism of several of these hydrocarbons (26)(27)(28)(29), make a critical examination of the metabolism of BP imperative. Recent studies of BP metabolism in vitro have Abbreviations used: BP, benzo[a]pyrene; 1-HOBP, 1-hydroxybenzo[a]pyrene; 2-, 3-, 4-, 5-, 6-, 7-, 8-, 9-, 10-, 11-, and 12-HOBP, other BP phenols; BP 1,6-quinone, benzo[a]pyrene 1,6-quinone; BP 3,6-quinone, BP 4,5-quinone, BP 6,12-quinone, and BP 11,12-quinone, other BP quinones; BP 1,2-dihydrodiol, trans-1,2-dihydroxy-1,2-dihydrobenzo [alpyrene; BP 2,4,7,9,[10][11] other

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