Binding of Drugs to End-Line Filters: A Study of Four Commonly Administered Drugs in Intensive Care Units

Muynck, C. De; Vroe, C. De; Remon, Jean Paul; Colardyn, Francis

doi:10.1111/j.1365-2710.1988.tb00202.x

Cited by 11 publications

(4 citation statements)

References 17 publications

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“…Some authors reported no losses on any type of digoxin filter, 11,12 while others reported losses as high as 73% when filtration was performed within the first 20 minutes using 0.22 µm filters. 13 Saturation of the filters might eventually limit losses. In the present study, the large quantity filtered could explain why no losses were observed when solutions were prepared using the copy of the commercial vehicle.…”

Section: Discussionmentioning

confidence: 99%

Stability of Compounded Digoxin Solution 0.05 mg/mL for Injection

et al. 2021

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Background: In 2015, commercial pediatric digoxin injection 0.05 mg/mL was discontinued, leaving only one adult concentration (0.25 mg/mL) for injection on the Canadian market. No published studies have documented the chemical stability over a long period of time of a diluted solution of digoxin for injection. Objective: The aim of this study was to assess the chemical stability of 2 digoxin injection formulations 0.05 mg/mL diluted in 2 vehicles stored at 5°C or a 25°C. Methods: The compounded solution of digoxin 0.05 mg/mL for injection was prepared with digoxin 0.25 mg/mL after dilution in 2 different vehicles, normal saline, and a compounding of the commercial vehicle. Half of the compounding products were stored in 2 mL transparent glass vials at 25°C and the other half at 5°C. Chemical stability was evaluated by HPLC–UV analysis on days 0, 14, 30, 60, 90, 120, 150, 180 for each temperature conditions. In addition, samples were tested for organoleptic change, presence of particular matter as well as sterility. Results: For all tested preparations, the concentration of digoxin remained above 90.0% of the initial concentration throughout the 180-day study. Furthermore, no organoleptic change was observed; particulate matter assessment was in acceptable range; and sterility specifications were met. Conclusions: Digoxin 0.05 mg/mL obtained with a dilution of digoxin 0.25 mg/mL by normal saline or a copy of the commercial vehicle remained stable for at least 180 days at 5°C and 25°C.

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Section: Discussionmentioning

confidence: 99%

Stability of Compounded Digoxin Solution 0.05 mg/mL for Injection

et al. 2021

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“…Hirakawa and colleagues 95 found that in-line filters decrease concentration of amphotericin B in filtered fluid, the proportion being dependent on the type of filter material used. Other authors have also reported a decrease in the availability of drugs such as digoxin and diazepam when infused through in-line filters 96 .…”

Section: Complications With In-line Filtersmentioning

confidence: 98%

Filters in Anaesthesia and Intensive Care

Tyagi

Kumar

Bhattacharya

et al. 2003

Anaesth Intensive Care

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The use of various types of filters in anaesthesia and intensive care seems ubiquitous, yet authentication of the practice is scarce and controversies abound. This review examines evidence for the practice of using filters with blood and blood product transfusion (standard blood filter, microfilter, leucocyte depletion filter), infusion of fluids, breathing systems, epidural catheters, and at less common sites such as with Entonox inhalation in non-intubated patients, forced air convection warmers, and air-conditioning systems. For most filters, the literature failed to support routine usage, despite this seemingly being popular and innocuous. The controversies, as well as guidelines if available, for each type of filter, are discussed. The review aims to rationalize the place of various filters in the anaesthesia and intensive care environment.

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“…De Muynck et al [32 ]reported the binding of different drugs to four different in-line filters during simulated infusion. These authors found filter absorption for digoxin and diazepam, little absorption for dopamine, while no absorption was detected for fentanyl.…”

Section: Discussionmentioning

confidence: 99%

Simulated Infusion of Paclitaxel with In-Line Filters

Bononi

Forgetta²,

Baldisserotto³

et al. 2011

Chemotherapy

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Background: Paclitaxel is one of the most effective anticancer drugs ever developed. To prevent hazards associated with intravenous (IV) administration which include the formation of microbubbles, microbiological contamination and particulate matter, the suppliers recommend that an in-line IV filter should be used during the infusion of the chemotherapeutic agent. Methods: To rule out the possibility that polyethersulfone (PES) membranes retain the paclitaxel during filtration, we carried out specific tests. Paclitaxel retention by PES in-line IV filters was evaluated by a simulated-drug IV infusion and high-performance liquid chromatography analysis. Results: In our model of study, no variation of paclitaxel concentration was revealed before and after filtration using two different filter devices. Conclusions: The results suggest that, under our experimental conditions, paclitaxel concentration in saline solution remains constant before and after filtration. Indeed, our study indicates that the filters analyzed herein, other than preventing hazards associated with IV administration, do not retain paclitaxel, thus avoiding the reduction of the drug concentration and potency during filtration.

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Binding of Drugs to End-Line Filters: A Study of Four Commonly Administered Drugs in Intensive Care Units

Cited by 11 publications

References 17 publications

Stability of Compounded Digoxin Solution 0.05 mg/mL for Injection

Stability of Compounded Digoxin Solution 0.05 mg/mL for Injection

Filters in Anaesthesia and Intensive Care

Simulated Infusion of Paclitaxel with In-Line Filters

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