Binding of Folic Acid to Serum Proteins

Markkanen, T; Rl, Pajula; Virtanen, Sari; Himanen, P; Järvinen, Mikko

doi:10.1159/000208201

Cited by 3 publications

(1 citation statement)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…υποστηρίζουν ότι ή άπορρόφησις των πολυγλουταμικών, τά όποια καί αντιπροσωπεύουν τά κύ ρια φυλλικά των τροφών, λαμβάνει χώραν κατά την νήστιν ένώ ή των μονογλουταμικών επισυμβαίνει καί επί έλλειπούσης νήστιδος κατά μήκος του είλέου. 'Εντός του πλάσματος κυκλοφορεί συνδεδεμένον μετά πρω τεΐνης(32). Τά επίπεδα πλάσματος κυμαίνονται άπό 5-20 Ng/Ml.…”

unclassified

Προσδιορισμος Φυλλικου Οξεος Και Βιταμινης Β12 Επι Παιδιων Πασχοντων Εκ Ρευματοειδους Αρθριτιδος

Κουτσιμανη¹

View full text Add to dashboard Cite

unclassified

Προσδιορισμος Φυλλικου Οξεος Και Βιταμινης Β12 Επι Παιδιων Πασχοντων Εκ Ρευματοειδους Αρθριτιδος

Κουτσιμανη¹

View full text Add to dashboard Cite

Identification of folate binding proteins in rat liver.

Zamierowski¹,

Wagner²

1977

Journal of Biological Chemistry

View full text Add to dashboard Cite

Specific and non-specific folate binding protein in normal and malignant human tissues

et al. 1978

View full text Add to dashboard Cite

Binding of tritiated folic acid by supernatants prepared from extracts of normal and leukaemic leucocytes, normal mucosa, and malignant tumours from different parts of the gastrointestinal tract has been measured using Sephadex-gel filtration and albumin-coated charcoal techniques. Non-specific binding (measured by Sephadex G-75 gel filtration) was almost invariably greater than specific binding measured by albumin-coated charcoal separation of bound and unbound folate. In nine normal leucocyte extracts, binding measured by Sephadex G-75 filtration ranged from 1.3 to 18.2 (mean 8.2) pg/mg protein and by albumin-coated charcoal from 1.0 to 14.8 (mean 6.7) pg/mg protein. Raised specific binding was found in the extracts from leucocytes of eight of 14 patients with chronic granulocytic leukaemia, in four substantially so (389, 121, 108, 59.7 pg/mg protein), but was only marginally increased in one of eight cases of acute myeloid leukaemia and in two of five cases of chronic lymphocytic leukaemia. Binding was normal in the extracts of all three cases of acute lymphoblastic leukaemia tested. Among the tissues of the gastrointestinal tract binding was greatest by the duodenal mucosa and liver. Extracts of carcinoma of the stomach and colon bound greater amounts of (3)H-folic acid than the corresponding normal mucosal extracts but the differences were not large. Sephadex G-200 gel chromatography showed more than one binding peak in the extracts of liver and duodenum but only one peak in the other tissues of the gastrointestinal tract, and only one peak, of molecular weight either about 50 000 or over 200 000, in the leucocyte extracts.

show abstract

Binding of Folic Acid to Serum Proteins

Cited by 3 publications

References 9 publications

Προσδιορισμος Φυλλικου Οξεος Και Βιταμινης Β12 Επι Παιδιων Πασχοντων Εκ Ρευματοειδους Αρθριτιδος

Προσδιορισμος Φυλλικου Οξεος Και Βιταμινης Β12 Επι Παιδιων Πασχοντων Εκ Ρευματοειδους Αρθριτιδος

Identification of folate binding proteins in rat liver.

Specific and non-specific folate binding protein in normal and malignant human tissues

Contact Info

Product

Resources

About