Binding of Gadobenate Dimeglumine to Proteins Extravasated into Interstitial Space Enhances Conspicuity of Reperfused Infarcts

Fm, Cavagna; Marzola, Pasquina; Daprà, Massimo; Maggioni, Fabio; Vicinanza, Eleonora; Pm, Castelli; C, de Haën; Luchinat, Claudio; Mf, Wendland; Saeed, Maythem

doi:10.1097/00004424-199406001-00018

Cited by 34 publications

(12 citation statements)

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“…However, the relaxivity of Gd-BOPTA (1) is higher than that of the liver-specific agents Mangafodipir or Gd-EOB-DTPA in the same tissue (14). This may be because of the high macromolecular binding of Gd-BOFTA, which could compensate for the lower hepatobiliary intake (15). The findings in the present study are of interest, inasmuch as liver enhancement after Gd-BOPTA at doses similar to other gadolinium chelates is comparable to that for Mangafodipir, and lesion conspicuity is increased, Gd-BOFTA may also become a useful hepatobiliary contrast agent as well (12,14).…”

Section: Discussionmentioning

confidence: 67%

Contrast‐enhanced MR imaging of the liver: Comparison between Gd‐BOPTA and mangafodipir

Schima

Petersein

Hahn

et al. 1997

Magnetic Resonance Imaging

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The purpose of the study was to evaluate the MR contrast agents gadolinium benzyloxypropionictetro-acetate (Gd-BOPTA) and Mangafodipir for liver enhancement and the lesion-liver contrast on T1W spin-echo (SE) and gradient-recalled-echo (GRE) images. Fifty-one patients (three groups of 17 patients each) with known or suspected liver lesions were evaluated with T1W SE (300/12) and GRE (77-80/2.3-2.5/80 degrees) images before and after intravenous (IV) Gd-BOPTA (0.1 or 0.05 mmol/kg) or Mangafodipir (5 mumol/kg) in phase II to III clinical trials. Quantitative analysis by calculating liver signal-to-noise ratio (SNR), lesion-liver contrast-to-noise ratio (CNR), and spleen-liver CNR was performed. Liver SNR and spleen-liver CNR were always significantly increased postcontrast. SNR was highest after application of 0.1 mmol/kg Gd-BOPTA (51.3 +/- 3.6, P < .05). CNR was highest after Mangafodipir (-22.6 +/- 2.7), but this was not significantly different from others (P = .07). Overall, GRE images were superior to SE images for SNR and CNR. Mangafodipir and Gd-BOPTA (0.1 mmol/kg) provide equal liver enhancement and lesion conspicuity postcontrast. By all criteria, contrast-enhanced T1-weighted GRE were comparable to SE images.

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Section: Discussionmentioning

confidence: 67%

Contrast‐enhanced MR imaging of the liver: Comparison between Gd‐BOPTA and mangafodipir

Schima

Petersein

Hahn

et al. 1997

Magnetic Resonance Imaging

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“…6. For Magnevist (1), Dotarem (2), Omniscan (3), ProHance (4) and Gadovist (6) the curves are similar to their corresponding NMRD profiles in water, but a significant difference is observed for Multihance (5), which is known to interact with plasma proteins (34,35). The presence of HSA also induces a viscosity increase (0.87 mPa s compared with 0.69 mPa s at 310 K), which should result in increased values of t R and decreased values of the relative diffusion constant D. Theoretical fittings performed with the parameters of the free Gd complexes but taking into account these viscosity effects on t R and D are shown in Fig.…”

Section: Interaction With Hsamentioning

confidence: 86%

Comparative study of the physicochemical properties of six clinical low molecular weight gadolinium contrast agents

Laurent

Elst

Müller

2006

Contrast Media & Molecular

381

312

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This paper compares the physicochemical properties of six low molecular weight clinical complexes of gadolinium studied under identical experimental conditions. Magnevist, Dotarem, Omniscan, ProHance, MultiHance and Gadovist were investigated by oxygen-17 relaxometry at different temperatures and by proton relaxometry at various magnetic fields, temperatures and media [pure water, zinc(II)-containing aqueous solutions and HSA-containing solutions]. Osmolality, viscosity and stability versus transmetallation by zinc(II) ions were added for a more comprehensive description. The relaxivities of the clinical formulations as measured in water are similar in the imaging magnetic field region, with a slightly better performance for MultiHance. This can be explained by a shorter distance between the hydrogen nuclei of the water molecule bound to the Gd(3+) ion and this paramagnetic centre. In contrast to the open-chain complexes, all macrocyclic systems (Dotarem, ProHance and Gadovist) are insensitive to transmetallation by zinc ions. The stability of the open-chain complexes with respect to transmetallation depends on the chemical structure of the ligand, with a better stability for MultiHance. The presence of human serum albumin has no significant effect on the proton relaxivity of Magnevist, Dotarem, Omniscan, ProHance and Gadovist but markedly increases the relaxivity of MultiHance because of a non-covalent interaction with the protein. As a result, the relaxivity of MultiHance in HSA-containing media of fixed concentration decreases with increasing concentration of the contrast agent.

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“…Due to a weak and transient interaction of the Gd-BOPTA contrast-effective moiety with serum albumin, this agent has a roughly two-fold T1-relaxivity in vivo when compared with Gd-DTPA and other standard-relaxivity gadolinium-based agents [12][13][14][15]. In the current study, the mean SI of the IM after Gd-BOPTA (44±16 au) was more than double that after Gd-DOTA (20±6 au).…”

mentioning

confidence: 48%

Myocardial delayed enhancement using a single dose (0.1 mmol/kg) of gadobenate dimeglumine: contrast resolution versus intraventricular blood and viable myocardium

et al. 2010

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Binding of Gadobenate Dimeglumine to Proteins Extravasated into Interstitial Space Enhances Conspicuity of Reperfused Infarcts

Cited by 34 publications

References 0 publications

Contrast‐enhanced MR imaging of the liver: Comparison between Gd‐BOPTA and mangafodipir

Contrast‐enhanced MR imaging of the liver: Comparison between Gd‐BOPTA and mangafodipir

Comparative study of the physicochemical properties of six clinical low molecular weight gadolinium contrast agents

Myocardial delayed enhancement using a single dose (0.1 mmol/kg) of gadobenate dimeglumine: contrast resolution versus intraventricular blood and viable myocardium

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