Binding of imidacloprid, thiamethoxam and <i>N</i>‐desmethylthiamethoxam to nicotinic receptors of <i>Myzus persicae</i>: pharmacological profiling using neonicotinoids, natural agonists and antagonists

Kayser, Hartmut; Lehmann, K.; Gomes, Marilyne; Schleicher, Wolfgang E.; Dotzauer, Karin; Moron, Margarethe; Maienfisch, Peter

doi:10.1002/ps.4249

Cited by 18 publications

(11 citation statements)

References 44 publications

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“…A recent study by van den Brink et al comparing the toxicity of imidacloprid, thiacloprid, and thiamethoxam to the mayfly, Cloeon dipterum , found comparable 28‐d LC50 values for imidacloprid (0.85 µg/L) and thiamethoxam (0.94 µg/L). Similar LC50 values for imidacloprid and thiamethoxam indicate that these neonicotinoids, albeit possibly acting on different nAChR receptor subunits , exert similar toxic effects on this species. Differences in LC50 or EC50 values between species are likely attributed to different metabolic biotransformation rates of thiamethoxam to clothianidin .…”

Section: Discussionmentioning

confidence: 82%

Comparative chronic toxicity of imidacloprid, clothianidin, and thiamethoxam to Chironomus dilutus and estimation of toxic equivalency factors

Cavallaro

Morrissey²,

Headley

et al. 2016

Enviro Toxic and Chemistry

113

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Nontarget aquatic insects are susceptible to chronic neonicotinoid insecticide exposure during the early stages of development from repeated runoff events and prolonged persistence of these chemicals. Investigations on the chronic toxicity of neonicotinoids to aquatic invertebrates have been limited to a few species and under different laboratory conditions that often preclude direct comparisons of the relative toxicity of different compounds. In the present study, full life-cycle toxicity tests using Chironomus dilutus were performed to compare the toxicity of 3 commonly used neonicotinoids: imidacloprid, clothianidin, and thiamethoxam. Test conditions followed a static-renewal exposure protocol in which lethal and sublethal endpoints were assessed on days 14 and 40. Reduced emergence success, advanced emergence timing, and male-biased sex ratios were sensitive responses to low-level neonicotinoid exposure. The 14-d median lethal concentrations for imidacloprid, clothianidin, and thiamethoxam were 1.52 μg/L, 2.41 μg/L, and 23.60 μg/L, respectively. The 40-d median effect concentrations (emergence) for imidacloprid, clothianidin, and thiamethoxam were 0.39 μg/L, 0.28 μg/L, and 4.13 μg/L, respectively. Toxic equivalence relative to imidacloprid was estimated through a 3-point response average of equivalencies calculated at 20%, 50%, and 90% lethal and effect concentrations. Relative to imidacloprid (toxic equivalency factor [TEF] = 1.0), chronic (lethality) 14-d TEFs for clothianidin and thiamethoxam were 1.05 and 0.14, respectively, and chronic (emergence inhibition) 40-d TEFs were 1.62 and 0.11, respectively. These population-relevant endpoints and TEFs suggest that imidacloprid and clothianidin exert comparable chronic toxicity to C. dilutus, whereas thiamethoxam induced comparable effects only at concentrations an order of magnitude higher. However, the authors caution that under field conditions, thiamethoxam readily degrades to clothianidin, thereby likely enhancing toxicity. Environ Toxicol Chem 2017;36:372-382. © 2016 SETAC.

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Section: Discussionmentioning

confidence: 82%

Comparative chronic toxicity of imidacloprid, clothianidin, and thiamethoxam to Chironomus dilutus and estimation of toxic equivalency factors

Cavallaro

Morrissey²,

Headley

et al. 2016

Enviro Toxic and Chemistry

113

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“…106,107) Therefore, in terms of the nAChR and the relationship between TMX and IMI, differential pharmacology via N-methyl substitution combined with cyclic or acyclic configurations, appears to possibly underlie the selectivity between distinct neonicotinoid binding sites. 103,105,107) As with IMI and clothianidin, TMX has similar rapid neuronal blocking effects on the exposed P. americana nerve cord, an effect which is inconsistent with the procide hypothesis, 106) although this effect is not always replicated between studies. 97) However, an analogue of dinotefuran (an N-methyl neonicotinoid, see below) containing the oxadiazine sub-structure is also potently neuroactive on the isolated cockroach nerve cord.…”

Section: Thiamethoxammentioning

confidence: 98%

“…101,102) However, the rate and degree of clothianidin production in vivo from TMX treated insects does not correlate with its rapid toxicological symptoms, suggesting that TMX must be neuroactive in its own right. 72 71,104,105) demonstrating that the oxadiazine residue itself does not select for different nAChR forms. Additionally, N-methyl IMI -a very close analogue of IMI (but with an N-methyl additional substituent as in TMX) is very weak at displacing [ 3 H]-IMI with a K i almost identical to TMX.…”

Section: Thiamethoxammentioning

confidence: 99%

“…Other channel modulators were without affect, ruling out the GABA rdl receptor as a principle target. 105,144) Demonstrating that spinosyns act on a population of nAChRs that are not targeted by neonicotinoids, IMI only weakly stimulates the binding of a) Mode of action classification in IRAC takes into account not only the biochemical target-site interaction (which defines the Group) but also chemical class and activity on pest insects with non-target site based resistance to existing commercialised compounds within the particular MoA Group at the time of classification request.…”

Section: Spinosynsmentioning

confidence: 99%

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The invertebrate pharmacology of insecticides acting at nicotinic acetylcholine receptors

Crossthwaite

Bigot

Camblin

et al. 2017

Journal of Pesticide Science

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The nicotinic acetylcholine receptor (nAChR) is a ligand-gated ion channel composed of 5 protein subunits arranged around a central cation selective pore. Several classes of natural and synthetic insecticides mediate their effect through interacting at nAChRs. This review examines the basic pharmacology of the neonicotinoids and related chemistry, with an emphasis on sapfeeding insects from the order Hemiptera, the principle pest target for such insecticides. Although the receptor subunit stoichiometry for endogenous invertebrate nAChRs is unknown, there is clear evidence for the existence of distinct neonicotinoid binding sites in native insect preparations, which reflects the predicted wide repertoire of nAChRs and differing pharmacology within this insecticide class. The spinosyns are principally used to control chewing pests such as Lepidoptera, whilst nereistoxin analogues are used on pests of rice and vegetables through contact and systemic action, the pharmacology of both these insecticides is unique and different to that of the neonicotinoids.

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“…Owing to fast evolution, B. tabaci nowadays has diverse biotypes worldwide among which the B and Q types can cause severe crops losses (Santos-Garcia et al, 2015). Green peach aphid M. persicae , which is another kind of important pest affecting tobaccos, has a broad spectrum of hosts all over the world (Cao et al, 2016; Kang et al, 2016; Kayser et al, 2016). The pests can both deprive plants of nutrients and transmit cucumber mosaic viruses or other pathogens (Zhao et al, 2015), resulting in immense losses of crop yield (Cao et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Bensulfuron-Methyl Treatment of Soil Affects the Infestation of Whitefly, Aphid, and Tobacco Mosaic Virus on Nicotiana tabacum

Islam

et al. 2016

Front. Plant Sci.

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Bensulfuron-methyl (BSM) is widely used in paddy soil for weed control. BSM residue in the soil has been known to inhibit the growth of sensitive crop plants. However, it is unknown whether BSM residue can affect the agrosystem in general. In this study, we have found significant effects of BSM on the infestation of Bemisia tabaci, Myzus persicae, and Tobacco mosaic virus (TMV) in Nicotiana tabacum. The soil was treated with BSM before the pest inoculation. The herbicide-treated tobaccos showed resistance to B. tabaci, but this resistance could not be detected until 15-day post-infestation when smaller number of adults B. tabaci appeared. In M. persicae assay, the longevity of all development stages of insects, and the fecundity of insects were not significantly affected when feeding on BSM-treated plants. In TMV assay, the BSM treatment also reduced virus-induced lesions in early infection time. However, the titer of TMV in BSM treated plants increased greatly over time and was over 40-fold higher than the mock-infected control plants after 20 days. Further studies showed that BSM treatment increased both jasmonic acid (JA) and salicylic acid (SA) levels in tobacco, as well as the expression of target genes in the JA and SA signaling pathways, such as NtWIPK, NtPR1a, and NtPAL. NtPR1a and NtPAL were initially suppressed after virus-inoculation, while NtRDR1 and NtRDR6, which play a key role in fighting virus infection, only showed up- or were down-regulated 20 days post virus-inoculation. Taken together, our results suggested that BSM residue in the soil may affect the metabolism of important phytohormones such as JA and SA in sensitive plants and consequently affect the plant immune response against infections such as whitefly, aphids, and viruses.

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Binding of imidacloprid, thiamethoxam and N‐desmethylthiamethoxam to nicotinic receptors of Myzus persicae: pharmacological profiling using neonicotinoids, natural agonists and antagonists

Cited by 18 publications

References 44 publications

Comparative chronic toxicity of imidacloprid, clothianidin, and thiamethoxam to Chironomus dilutus and estimation of toxic equivalency factors

Comparative chronic toxicity of imidacloprid, clothianidin, and thiamethoxam to Chironomus dilutus and estimation of toxic equivalency factors

The invertebrate pharmacology of insecticides acting at nicotinic acetylcholine receptors

Bensulfuron-Methyl Treatment of Soil Affects the Infestation of Whitefly, Aphid, and Tobacco Mosaic Virus on Nicotiana tabacum

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