1988
DOI: 10.1021/bi00408a028
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Binding of leukotriene C4 to rat lung fibroblasts and stimulation of collagen synthesis in vitro

Abstract: Arachidonate metabolites are potent biological mediators affecting multiple cellular functions. Although prostaglandins of the E series, which are products of the cyclooxygenase pathway, have been known as inhibitors or down-regulators of fibroblast proliferation and collagen synthesis, the more recently discovered products of the 5-lipoxygenase pathway have not been as extensively investigated with regard to fibroblast function. In this study, a sulfidopeptide product of the lipoxygenase pathway, leukotriene … Show more

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Cited by 86 publications
(42 citation statements)
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“…5, b and d). It has been reported that cysteinyl LTs increase collagen synthesis in fibroblasts (33,34), and our report is the first to demonstrate the expression of CysLTs in fibroblasts. Further study is needed to uncover yet unknown roles of cysteinyl LTs in wound healing and pathological collagen synthesis.…”
Section: Different Tissue Distribution Of Cyslt 1 and Cyslt 2 Mrna Insupporting
confidence: 72%
“…5, b and d). It has been reported that cysteinyl LTs increase collagen synthesis in fibroblasts (33,34), and our report is the first to demonstrate the expression of CysLTs in fibroblasts. Further study is needed to uncover yet unknown roles of cysteinyl LTs in wound healing and pathological collagen synthesis.…”
Section: Different Tissue Distribution Of Cyslt 1 and Cyslt 2 Mrna Insupporting
confidence: 72%
“…In earlier studies, the fibroblast proliferation generated in in vitro cocultures of macrophages and human skin fibroblasts could also be achieved by direct stimulation of the fibroblasts with cys-LTs in the absence of macrophages (35). In another study, again before the specific receptors were defined, cys-LTs stimulated collagen biosynthesis by rat lung fibroblasts (36). One might speculate that in the context of innate host defense, the cys-LTs generate a microvascular leak as part of the acute response and then a typical chronic inflammatory cellular profile.…”
Section: Discussionmentioning
confidence: 98%
“…We have previously reported that cysLTs can cause fibrocytes to proliferate (29). Additionally, cysLTs are known to induce fibroblast proliferation (44) and collagen secretion (45).…”
Section: Discussionmentioning
confidence: 99%