2005
DOI: 10.1016/j.yexcr.2005.01.012
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Binding of Par-4 to the actin cytoskeleton is essential for Par-4/Dlk-mediated apoptosis

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Cited by 34 publications
(71 citation statements)
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“…9 In differentiating ES cells, however, we found that PAR-4 was co-distributed with F-actin to a high extent without resulting in apoptosis. Using an antibody against DLK we could not detect its expression in differentiating ES cells (data not shown).…”
Section: Role Of Exon 3 In Par-4-induced Apoptosismentioning
confidence: 63%
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“…9 In differentiating ES cells, however, we found that PAR-4 was co-distributed with F-actin to a high extent without resulting in apoptosis. Using an antibody against DLK we could not detect its expression in differentiating ES cells (data not shown).…”
Section: Role Of Exon 3 In Par-4-induced Apoptosismentioning
confidence: 63%
“…5,6 There has been, however, an ongoing controversy with respect to the subcellular site at which PAR-4 induces apoptosis. 8,9 To determine the subcellular localization of PAR-4 in embryoid body (EB)-derived cells (EBCs), we performed immunocytochemistry on different stages of EBC differentiation ( Figure 1A and 1B). Consistent with our previous studies, we found that PAR-4 was localized in both the cytosol and the nucleus.…”
Section: Differentiation-stage Specific Expression Of Two Par-4 Isofomentioning
confidence: 99%
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“…In addition to its pro-apoptotic functions, PAR-4 has been shown to regulate the activity of choline acetyl transferase, to inhibit choline uptake, and to regulate synaptic plasticity [133][134][135] . In this regard, it may be of interest that PAR-4 has been found to be temporarily associated with the actin cytoskeleton [136] . Our group has described a short form of PAR-4 that acts as dominant negative regulator of apoptosis by forming actin-associated heterodimers with the pro-apoptotic long form of PAR-4 [6] .…”
Section: Lipid Rafts and Slips: A Platform For Cell Signaling Pathwaysmentioning
confidence: 99%
“…ZIPK has been shown to phosphorylate STAT3 on Ser-727, thus enhancing the transcriptional activity of STAT3 (7). Vetterkind et al (8) have demonstrated that prostate apoptosis response-4 (Par-4), which is characterized mainly as a proapoptotic protein, targets ZIPK to the cytoskeleton in nonmuscle cells, leading to apoptosis. By contrast, in smooth muscle cells, Par-4 supports contractility by targeting ZIPK to the cytoskeleton (9).…”
Section: Introductionmentioning
confidence: 99%