Binding of silver sulfadiazine to the cellular components of Pseudomonas aeruginosa

Modak, Shanta; Fox, Charles L.

doi:10.1016/0006-2952(73)90341-9

Cited by 196 publications

(108 citation statements)

References 12 publications

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“…This, coupled with electrode corrosion would be used to explain any bacteriostatic action in other electrodes. The silver ion was suggested as the reason for such a strong bactericidal effect and other research on the antibacterial effects of silver sulfadiazine would appear to support this [45,46]. Electrically injected silver ions in this experiment were shown to be at least as effective as an antibiotic.…”

Section: Electrically Induced Bactericidal Effects Of Silversupporting

confidence: 54%

Electrical methods of controlling bacterial adhesion and biofilm on device surfaces

Freebairn

Linton

Harkin‐Jones

et al. 2013

Expert Review of Medical Devices

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SummaryThis review will summarize the significant body of research within the field of electrical methods of controlling the growth of microorganisms. We examine the progress from early work using current to kill bacteria in static fluids to more realistic treatment scenarios such as flow-through systems designed to imitate the human urinary tract. Additionally, the electrical enhancement of biocide and antibiotic efficacy will be examined alongside recent innovations including the biological applications of acoustic energy systems to prevent bacterial surface adherence. Particular attention will be paid to the electrical engineering aspects of previous work, such as electrode composition, quantitative electrical parameters, and the conductive medium used. Scrutiny of published systems from an electrical engineering perspective will help to facilitate improved understanding of the methods, devices and mechanisms that have been effective in controlling bacteria, as well as providing insights and strategies to improve the performance of such systems and develop the next generation of antimicrobial bioelectric materials.

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Section: Electrically Induced Bactericidal Effects Of Silversupporting

confidence: 54%

Electrical methods of controlling bacterial adhesion and biofilm on device surfaces

Freebairn

Linton

Harkin‐Jones

et al. 2013

Expert Review of Medical Devices

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“…Ag + ions are highly toxic to all micro-organisms, perhaps due to poisoning of the respiratory electron transport chains and components of DNA replication (Modak & Fox, 1973 ;Russell & Hugo, 1994). Although bacterial Ag + resistance has been periodically reported, the basis was not studied before our recent efforts Gupta et al, 1999 ;Silver et al, 1999a, b).…”

Section: Some Metal Cations (Zn#mentioning

confidence: 99%

Diversity of silver resistance genes in IncH incompatibility group plasmids

et al. 2001

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Silver compounds are used as antimicrobial agents in medicine and bacteria that develop resistance to silver cations (Ag M ) pose problems similar to those of antibiotic-resistant bacteria. The first set of Ag M resistance genes (sil) was from plasmid pMG101, now assigned to the IncHI incompatibility group. Questions of whether sil genes are unique to pMG101 or are more widely found, and whether they are associated with a specific incompatibility group or occur in many plasmid groups and on bacterial chromosomes were addressed. sil genes were identified in five IncH plasmids, but not in plasmids of the IncP incompatibility group. Three sil genes (silP, silR and silE) from these plasmids were PCR-amplified, cloned, sequenced and compared to those of pMG101. Differences of 0-50 nt per kb of sequence were found. Predicted gene products were 0-6 % different in amino acid sequence, but the differences did not alter residues thought to be involved in protein function (see supplementary data at http ://mic.sgmjournals.org or http ://www.uic.edu/depts/mcmi/individual/gupta/index.htm). For representative IncH plasmid R476b and pMG101 the effects of Ag M exposure on resistance levels were measured by growth. The inducibility of silC, silR and silE gene expression after Ag M exposure was studied by reverse transcriptase (RT)-PCR. Silver resistance increased after Ag M exposure for strains carrying plasmid R476b. silC and silE expression from R476b was inducible after Ag M exposure and was constitutive and high from pMG101. The mRNA levels for the regulatory gene silR was constitutive for both pMG101 and R476b. Close homologues for silABC(ORF96)RS from pMG101 are clustered on the chromosomes of Escherichia coli strains K-12 and O157 :H7, without contiguous silP and silE homologues. Insertion deletions of the E. coli K-12 chromosomal homologues for silA and silP gave Ag M hypersensitivity for growth. The silA homologue knockout was complemented back to wild-type resistance by the same gene cloned on a plasmid. Homologues of sil genes have also been identified on other enterobacterial genomes.

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“…[14][15][16] In addition, Ag + can interact with and denature DNA and RNA, thereby inhibiting cell division and replication. 13,17 More recently, a variety of silver-based products have been commercialized varying from wound dressing to vascular and urinary catheters. 18,19 The carrier materials used for silver loading vary from alginates (i.e., Acticoat, Smith and Nephew and Silvercel, Johnson & Johnson) to hydrogel (i.e., Silvasorb, Medline), hydrocolloid (i.e., Contreet H, Coloplast), and foam (i.e., Contreet F, Coloplast).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Properties of Nanostructured Hydrogel Webs Containing Silver

et al. 2009

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The need exists for biomaterials that prevent biofilm formation and associated infections. In this report, we have studied the synthesis, processing, and antimicrobial behavior of new silver-containing thermoplastic hydrogel nanofibrous webs. Thermoplastic hydrogels were synthesized from multiblock PEG-POSS polyurethanes (PEG: poly(ethylene gylcol); POSS: polyhedral oligosilsesquioxane) and electrospun into nanofibrous webs (diameter ∼150 nm), with or without AgNO 3 . The nanofibrous hydrogels exhibited unusual shrinkage during water uptake, yielding a uniquely dense structure compared to hydrogels prepared from cast films. Antimicrobial activity was examined using exposure to Escherichia coli with daily refreshment of medium and inoculation to a controlled cell density. Nanofibrous hydrogels without silver featured the most rapid and most extensive biofilm formation, while the silver-containing nanofibrous hydrogel featured outstanding biofilm resistance, with biofilm formation taking hold only after 14 days of incubation in daily refreshed bacterial cultures. We envision application of the unique antimicrobial hydrogels as wound dressings that combine sustained bactericidal properties and lack of volumetric swelling during water uptake.

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Binding of silver sulfadiazine to the cellular components of Pseudomonas aeruginosa

Cited by 196 publications

References 12 publications

Electrical methods of controlling bacterial adhesion and biofilm on device surfaces

Electrical methods of controlling bacterial adhesion and biofilm on device surfaces

Diversity of silver resistance genes in IncH incompatibility group plasmids

Antimicrobial Properties of Nanostructured Hydrogel Webs Containing Silver

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