Binding of the Host–Guest Complex of 7-Aminoflavone/β-Cyclodextrin with Calf Thymus DNA: A Spectroscopic and Molecular Docking Study

Chandrasekaran, Sowrirajan; Yousuf, Sameena; Enoch, Israel V.M.V.; Santhanam, V.

doi:10.1007/s10953-014-0187-y

Cited by 5 publications

(3 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The normal modes of binding are groove-binding and intercalation [21]. These bindings can be studied using spectroscopy [22,23]. We studied the binding of 1-GNPs to calf thymus DNA.…”

Section: Resultsmentioning

confidence: 99%

Binding interaction of a fluoranthene–thiol on gold nanoparticles with β-cyclodextrin and DNA

Thangaraj

Antony

Yousuf

et al. 2016

Journal of Experimental Nanoscience

Self Cite

View full text Add to dashboard Cite

In this paper, we report the preparation of a fluoranthene-thiol derivative, the assembly of the compound onto gold nanoparticles, and their binding to b-cyclodextrin and DNA. The synthesised fluoranthene-thiol is characterised using infra-red (IR), nuclear magnetic resonance (NMR), and mass spectrometric techniques. The gold nanoparticles are characterised using transmission electron microscopy and energy dispersive X-ray spectroscopy microanalysis. The size of the nanoparticles is 5 § 1 nm. The thiolgold nanoparticles bind to b-cyclodextrin, and DNA and the fluorescence spectra show enhancement of fluorescence on the binding. The thiol-gold nanoparticles form a host-guest complex with b-cyclodextrin and the binding constant of the complex is 1330 mol ¡1 dm 3 . This reveals the openness of the thiol on the surface of the gold nanoparticles.

show abstract

“…The normal modes of binding are groove-binding and intercalation [21]. These bindings can be studied using spectroscopy [22,23]. We studied the binding of 1-GNPs to calf thymus DNA.…”

Section: Resultsmentioning

confidence: 99%

Binding interaction of a fluoranthene–thiol on gold nanoparticles with β-cyclodextrin and DNA

Thangaraj

Antony

Yousuf

et al. 2016

Journal of Experimental Nanoscience

Self Cite

View full text Add to dashboard Cite

show abstract

“…In this sense, dimethyl-β-cyclodextrin has been used to include diverse drugs like paclitaxel, , hydroxymethylnitrofurazone, luteolin, 4-hydroxycoumarin, catechin, (−)-epigallocatechin galate, and morin, improving their complexing ability and stabilization of the incorporated drug. Even though cyclodextrins are recognized by the ability to form such complexes as reported elsewhere (vide supra), reports on drugs that bind to ct DNA and solubilized by cyclodextrin are scanty. − Also, cyclodextrins are recognized to increase the solubility of complexes and/or to modulate the binding of small molecules to ct DNA by selectively blocking/orienting the drug upon its binding.…”

Section: Introductionmentioning

confidence: 99%

Influence of DMβCD on the Interaction of Copper(II) Complex of 6-Hydroxychromone-3-carbaldehyde-3-hydroxybenzoylhydrazine with ctDNA

et al. 2020

View full text Add to dashboard Cite

The interaction mechanism between a scarcely soluble copper(II) complex of Cu(II)-6-hydroxychromone-3-carbaldehyde-(3′-hydroxy)benzoylhydrazone (CuCHz) in aqueous solution and its DMβCD complex was studied in the presence of ctDNA through spectroscopy and thermodynamic methods. The thermodynamic results indicate that the binding process of the CuCHz–DMβCD inclusion complex is a spontaneous process and the inclusion is enthalpy-driven. The binding constants of CuCHz and CuCHz–DMβCD with ctDNA are 2.69 × 103 and 14.7 × 103 L mol–1, respectively. The stoichiometry of the complex is 1:1, and the determined thermodynamic indicates that the process of binding is spontaneous and entropy-driven. A competitive binding titration with ethidium bromide revealed that CuCHz efficiently displaces EB from the EB–DNA system. In addition to the thermal denaturation experiments and docking studies, we can confirm that the mode of binding of this complex to ctDNA is intercalation mode. The presence of DMβCD enhances the aqueous solubility of CuCHz; nevertheless, the cyclodextrin did not affect the interaction of CuCHz with ctDNA because the inclusion complex breaks down when it binds with ctDNA.

show abstract

“…β-Cyclodextrin (β-CD) is a doughnut-shaped cyclic oligosachcharide containing a hydrophobic cavity capable of accommodating guest molecules of appropriate size [9]. The biological activities of chromenones have been well-documented [10] and the bindings of native chromenones to β-CD and duplex DNA have been reported by our research group [10][11][12][13][14][15][16]. This article provides the possible modes and strengths of binding of the chromenones viz., 2'-Hydroxyflavanone (2'HF), Hesperidin (HP), Naringin (NR), 7-aminoflavone (7AF), Baicalein (BC), Coumarin153 (C153) and Coumarin314 (C314) loaded, aminoethylamino-modified dextran-coated iron oxide nanoparticles to β-CD and DNA.…”

Section: Introductionmentioning

confidence: 99%

Chromenone-conjugated magnetic iron oxide nanoparticles. Toward conveyable DNA binders

Yousuf

Enoch

Paulraj

et al. 2015

Colloids and Surfaces B: Biointerfaces

View full text Add to dashboard Cite

Binding of the Host–Guest Complex of 7-Aminoflavone/β-Cyclodextrin with Calf Thymus DNA: A Spectroscopic and Molecular Docking Study

Cited by 5 publications

References 30 publications

Binding interaction of a fluoranthene–thiol on gold nanoparticles with β-cyclodextrin and DNA

Binding interaction of a fluoranthene–thiol on gold nanoparticles with β-cyclodextrin and DNA

Influence of DMβCD on the Interaction of Copper(II) Complex of 6-Hydroxychromone-3-carbaldehyde-3-hydroxybenzoylhydrazine with ctDNA

Chromenone-conjugated magnetic iron oxide nanoparticles. Toward conveyable DNA binders

Contact Info

Product

Resources

About