Binding of two bacterial biofilms to dialkyl carbamoyl chloride (DACC)-coated dressings <i>in vitro</i>

Cooper, Rose; Jenkins, Leighton

doi:10.12968/jowc.2016.25.2.76

Cited by 31 publications

(31 citation statements)

References 22 publications

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“…The fact that biofilms are especially tolerant to antibiotics explains why some wounds fail to respond to antimicrobial interventions. 48,53 Studies have also shown that higher silver nitrate levels are required to treat an infection caused by a biofilm-associated bacteria strain than a culture of planktonic cell of the same strain. 54 Mahami et al have reported that the biofilm phenotype of Staphylococcus aureus was found to be four-times more resistant to silver nitrate than planktonic cells.…”

Section: Discussionmentioning

confidence: 99%

“…One other way of disrupting the biofilm concerns the use of superabsorbent and absorbent dressings, which remove bacteria from the wound by absorbing and maintaining the bacteria in the dressing matrix or by hydrophobic interactions between the wound contact layer and bacteria. 23,47 Recently, Cooper and Jenkins 48 have demonstrated that dialkyl carbamoyl chloride (DACC)-coated dressings bind MRSA biofilm in vitro.…”

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confidence: 99%

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Antibacterial properties and reduction of MRSA biofilm with a dressing combining polyabsorbent fibres and a silver matrix

et al. 2016

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Antibacterial properties and reduction of MRSA biofilm with a dressing combining polyabsorbent fibres and a silver matrix

et al. 2016

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“…Microbes, including fungi, are irreversibly bound through hydrophobic interactions to the DACC coating on the dressing surface. Recent in vitro evidence indicates that DACC enhances binding of methicillin‐resistant Staphylococcus aureus and biofilms.…”

Section: Discussionmentioning

confidence: 99%

Dialkylcarbamoyl chloride-coated versus alginate dressings after pilonidal sinus excision: a randomized clinical trial (SORKYSA study)

et al. 2020

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Background Disease of the pilonidal sinus is a common condition that affects mainly young adults. Options for management include excision of the sinus tracts, leaving the wound open to heal by secondary intention. The aim of this study was to compare wound healing with dialkylcarbamoyl chloride (DACC)‐coated dressings versus alginate dressings. Methods This multicentre trial randomized consecutive patients undergoing surgery for pilonidal disease to postoperative wound care with either DACC‐coated or alginate dressings. The primary outcome was the proportion of wounds healed after 75 days. Secondary outcomes were the local status of wounds during the healing process, the quality assessment of the dressings by the patient, and the time needed to return to usual activities. Results A total of 246 patients were included: 120 in the DACC‐coated group and 126 in the alginate group. In per‐protocol analysis, there were significantly more patients with completely healed wounds after 75 days in the DACC group than in the alginate group: 78 of 103 (75·7 per cent) versus 58 of 97 (60 per cent) respectively (odds ratio 2·55, 95 per cent c.i. 1·12 to 5·92; P = 0·023). During follow‐up, wounds with alginate dressings had more fibrin than those with DACC‐coated dressings, but the difference was not significant (P = 0·079). There was no difference between the two arms in patients' assessment of the dressings. Conclusion The number of wounds completely healed at 75 days was significantly higher for DACC‐coated compared with alginate dressings. However, the preplanned, clinically significant improvement in healing of 20 per cent was not reached. Registration number: NCT02011802 ( https://clinicaltrials.gov/).

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“…75 These high-technology dressings are active also against methicillin-resistant S.aureus (MRSA) and Pseudomonas aeruginosa, two of the most difficult-to-treat bacteria. 76 Dressing changes should occur daily, on alternate days, or twice a week according to the size/characteristics of the lesions and the type of dressing applied.…”

Section: Topical Treatmentmentioning

confidence: 99%

<p>Management of digital ulcers in systemic sclerosis</p>

Barsotti¹,

Battista²,

Venturini³

et al. 2019

CWCMR

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Systemic sclerosis (SSc) is a rare disease characterized by autoimmune pathogenesis, alterations to the vascular system, and fibrosis of the skin and internal organs. Digital ulcers (DUs) are common in SSc patients, and represent a major burden for the patients. The management of DUs in systemic sclerosis is difficult, because it needs a multimodal therapeutic approach, as local treatment alone is usually insufficient and also systemic treatment with vasoactive drugs and modification of the lifestyle are usually required for healing of the wounds. In this review, we describe the optimal management of DUs according to recent literature and our clinical practice for systemic and local treatment of chronic digital wounds in SSc patients.

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Binding of two bacterial biofilms to dialkyl carbamoyl chloride (DACC)-coated dressings in vitro

Abstract: Objective: To date only planktonic bacteria have been shown to bind irreversibly to DACCcoated Cutimed® Sorbact® dressings, this study, therefore, was designed to determine whether bacterial biofilm bound to the DACC-coating of Cutimed® Sorbact® dressings in vitro. Method

Cited by 31 publications

References 22 publications

Antibacterial properties and reduction of MRSA biofilm with a dressing combining polyabsorbent fibres and a silver matrix

Antibacterial properties and reduction of MRSA biofilm with a dressing combining polyabsorbent fibres and a silver matrix

Dialkylcarbamoyl chloride-coated versus alginate dressings after pilonidal sinus excision: a randomized clinical trial (SORKYSA study)

<p>Management of digital ulcers in systemic sclerosis</p>

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