Binding properties of KB-5492, a novel anti-ulcer agent, at σ receptors in porcine gastric fundic mucosa

Effects of sigma ligands on the cloned μ‐, δ‐ and k‐opioid receptors co‐expressed with G‐protein‐activated K+ (GIRK) channel in Xenopus oocytes

“…The antipsychotic effects of a ligands have elicited interest in their therapeutic application to schizophrenia and drug abuse (Debonnel, 1993). It has also been suggested that a ligands may be useful for the treatment of pain (Chien & Pasternak, 1994;Kest et al, 1995), dystonia (Walker et al, 1988;1993), cerebral ischaemia (O'Neill et al, 1995), amnesia (Earley et al, 1991), epilepsy (Tortella & Musacchio, 1986;Tortella et al, 1989), ulcer (Pascaud et al, 1990;Harada et al, 1994), and tumours (Brent & Pang, 1995). a Ligands modulate the dopaminergic (Steinfels & Tam, 1989), noradrenergic (Gonzalez-Alvear & Werling, 1995) and acetylcholinergic Matsuno et al, 1993) systems, the NMDA receptor-mediated response (Monnet et al, 1992), carbachol-induced phosphatidylinositol turnover (Candura et al, 1990), and blockade of tonic potassium channels (Wu et al, 1991;Morio et al, 1994).…”

“…The antipsychotic effects of a ligands have elicited interest in their therapeutic application to schizophrenia and drug abuse (Debonnel, 1993). It has also been suggested that a ligands may be useful for the treatment of pain (Chien & Pasternak, 1994;Kest et al, 1995), dystonia (Walker et al, 1988;1993), cerebral ischaemia (O'Neill et al, 1995), amnesia (Earley et al, 1991), epilepsy (Tortella & Musacchio, 1986;Tortella et al, 1989), ulcer (Pascaud et al, 1990;Harada et al, 1994), and tumours (Brent & Pang, 1995).…”