Binding the immunoglobulins of human serum by nanodiamonds

Барон, А. В.; Osipov, N V; Olkhovskiy, I. A.; Puzyr, A. P.; Bondar, V. S.

doi:10.1134/s1607672914040127

Cited by 8 publications

(4 citation statements)

References 7 publications

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“…Further probing ND effects on host immunity, several studies reveal the adsorption of IgG antibodies onto modified NDs, elevating their applicability in diverse medical contexts. [188] NDs exhibit binding capabilities with Complement component 1q (C1q), a complement pathway protein pivotal in various physiological and pathological processes, endowing them with the ability to modulate host inflammatory signals selectively. [189] Enhancing the non-specific binding aspect of NDs requires attention, as extended blood circulation (30 min) leads to ND attachment on red blood cell membranes, potentially impacting their excretion.…”

Section: Exploitation Of Nds As Vaccine Enhancermentioning

confidence: 99%

Nanodiamonds: A Cutting‐Edge Approach to Enhancing Biomedical Therapies and Diagnostics in Biosensing

Hyder,

Ali,

Buledi

et al. 2024

The Chemical Record

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Nanodiamonds (NDs) have garnered attention in the field of nanomedicine due to their unique properties. This review offers a comprehensive overview of NDs synthesis methods, properties, and their uses in biomedical applications. Various synthesis techniques, such as detonation, high‐pressure, high‐temperature, and chemical vapor deposition, offer distinct advantages in tailoring NDs′ size, shape, and surface properties. Surface modification methods further enhance NDs′ biocompatibility and enable the attachment of bioactive molecules, expanding their applicability in biological systems. NDs serve as promising nanocarriers for drug delivery, showcasing biocompatibility and the ability to encapsulate therapeutic agents for targeted delivery. Additionally, NDs demonstrate potential in cancer treatment through hyperthermic therapy and vaccine enhancement for improved immune responses. Functionalization of NDs facilitates their utilization in biosensors for sensitive biomolecule detection, aiding in precise diagnostics and rapid detection of infectious diseases. This review underscores the multifaceted role of NDs in advancing biomedical applications. By synthesizing NDs through various methods and modifying their surfaces, researchers can tailor their properties for specific biomedical needs. The ability of NDs to serve as efficient drug delivery vehicles holds promise for targeted therapy, while their applications in hyperthermic therapy and vaccine enhancement offer innovative approaches to cancer treatment and immunization. Furthermore, the integration of NDs into biosensors enhances diagnostic capabilities, enabling rapid and sensitive detection of biomolecules and infectious diseases. Overall, the diverse functionalities of NDs underscore their potential as valuable tools in nanomedicine, paving the way for advancements in healthcare and biotechnology.

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Section: Exploitation Of Nds As Vaccine Enhancermentioning

confidence: 99%

Nanodiamonds: A Cutting‐Edge Approach to Enhancing Biomedical Therapies and Diagnostics in Biosensing

Hyder,

Ali,

Buledi

et al. 2024

The Chemical Record

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show abstract

“…Exploring further the effects of NDs on host immunity, several studies have revealed that IgG antibodies can be adsorbed by modified NDs, which can potentiate their use in several medical settings [37]. NDs possess the ability to bind to Complement component 1q (C1q), a protein of the complement pathway which is involved in many physiological and pathological processes [38], enabling them to modulate host inflammatory signals in an specific manner.…”

Section: Nanodiamonds As Potential Vaccine Enhancersmentioning

confidence: 99%

Applications of Nanodiamonds in the Detection and Therapy of Infectious Diseases

2019

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We are constantly exposed to infectious diseases, and they cause millions of deaths per year. The World Health Organization (WHO) estimates that antibiotic resistance could cause 10 million deaths per year by 2050. Multidrug-resistant bacteria are the cause of infection in at least one in three people suffering from septicemia. While antibiotics are powerful agents against infectious diseases, the alarming increase in antibiotic resistance is of great concern. Alternatives are desperately needed, and nanotechnology provides a great opportunity to develop novel approaches for the treatment of infectious diseases. One of the most important factors in the prognosis of an infection caused by an antibiotic resistant bacteria is an early and rigorous diagnosis, jointly with the use of novel therapeutic systems that can specifically target the pathogen and limit the selection of resistant strains. Nanodiamonds can be used as antimicrobial agents due to some of their properties including size, shape, and biocompatibility, which make them highly suitable for the development of efficient and tailored nanotherapies, including vaccines or drug delivery systems. In this review, we discuss the beneficial findings made in the nanodiamonds field, focusing on diagnosis and treatment of infectious diseases. We also highlight the innovative platform that nanodiamonds confer for vaccine improvement, drug delivery, and shuttle systems, as well as their role in the generation of faster and more sensitive clinical diagnosis.

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“…6,7,[12][13][14][15][16] Since many potential biomedical applications of NDs entail their contact with the humors (bodily fluids), it is important also to understand the response of the human humoral immune system towards these nanomaterials. While there have been studies involving the effect of NDs on human blood components, 17,18 studies that concern the human complement, the subject of the present work, have not been reported.…”

Section: Introductionmentioning

confidence: 95%

Recognition protein C1q of innate immunity agglutinates nanodiamonds without activating complement

Bélime

Thielens

Gravel

et al. 2019

Nanomedicine: Nanotechnology, Biology and Medicine

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Binding the immunoglobulins of human serum by nanodiamonds

Cited by 8 publications

References 7 publications

Nanodiamonds: A Cutting‐Edge Approach to Enhancing Biomedical Therapies and Diagnostics in Biosensing

Nanodiamonds: A Cutting‐Edge Approach to Enhancing Biomedical Therapies and Diagnostics in Biosensing

Applications of Nanodiamonds in the Detection and Therapy of Infectious Diseases

Recognition protein C1q of innate immunity agglutinates nanodiamonds without activating complement

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