Binge Drinking and Nitric Oxide Metabolites in Chronic Liver Disease

Oekonomaki, Eleni; Notas, George; Mouzas, Ioannis; Valatas, Vassilis; Skordilis, Panagiotis; Xidakis, C.; Kouroumalis, Elias

doi:10.1093/alcalc/agh030

Cited by 25 publications

(12 citation statements)

References 38 publications

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“…By contrast, in patients with cirrhosis, either viral or alcoholic, no significant increase was found after EtOH administration. However, basal levels in cirrhotics were significantly elevated (82.2 ± 13.8 vs. 43.1 ± 7.2 mol/l, p < 0.01) compared to healthy controls [43]. The increase of NO production might protect liver microcirculation from a deleterious EtOH effect.…”

Section: Effect Of Etoh On No Levelsmentioning

confidence: 80%

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Ethanol Metabolism and Effects: Nitric Oxide and its Interaction

Deng

Deitrich²

2007

CCP

110

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Ethanol (EtOH) in alcoholic beverages is consumed by a large number of individuals and its elimination is primarily by oxidation. The role of nitric oxide (NO) in EtOH's effects is important since NO is one of the most prominent biological factors in mammals. NO is constantly formed endogenously from L-arginine. Dose and length of EtOH exposure, and cell type are the main factors affecting EtOH effects on NO production. Either acute or chronic EtOH ingestion affects inducible NO synthase (iNOS) activity. However it seems that EtOH suppresses induced-NO production by inhibition of iNOS in different cells. On the other hand, it is clear that acute low doses of EtOH increase both the release of NO and endothelial NOS (eNOS) expression, and augment endothelium-mediated vasodilatation, whereas higher doses impair endothelial functions. EtOH selectively affects neuronal NOS (nNOS) activity in different brain cells, which may relate to various behavioral interactions. Therefore, there is an excellent chance for EtOH and NO to react with each other. Effects of EtOH on NO production and NOS activity may be important to EtOH modification of cell or organ function. Nitrosated compounds (alkyl nitrites) are often found as the interaction products, which might be one of the minor pathways of EtOH metabolism. NO also inhibits EtOH metabolizing enzymes. Furthermore, NO is involved in EtOH induced liver damage and has a role in fetal development during EtOH exposure in pregnancy. The mechanisms underlying these effects are only partially understood. Hence, the current discussion of the interaction of EtOH and NO is presented.

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Section: Effect Of Etoh On No Levelsmentioning

confidence: 80%

“…Acute or chronic EtOH consumption increases blood NO in both intact animals [38,39,40,41] and humans [42,43]. For example, EtOH (80 g as a 40% solution) was ingested within 30 min after an over-night fast by human subjects.…”

Section: Effect Of Etoh On No Levelsmentioning

confidence: 99%

Ethanol Metabolism and Effects: Nitric Oxide and its Interaction

Deng

Deitrich²

2007

CCP

110

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“…Other factor which may be associated with the increased airway temperature is blood acetaldehyde level, which indirectly causes vasodilation [44] and increases after alcohol intake, resulting in increase blood flow [45]. The temporary effect of alcohol intake on increasing blood NO concentration is reported to last more than 1 hour and up to several hours [40,41], and blood acetaldehyde level returns to normal within 4 hours after alcohol intake [45]. Given that increased local blood flow in the upper respiratory tract contributes to protection against viruses, daily drinkers of small amounts of alcohol may have an advantage on viral protection over “weekend” or “occasional” drinkers.…”

Section: Discussionmentioning

confidence: 99%

Frequent alcohol drinking is associated with lower prevalence of self-reported common cold: a retrospective study

et al. 2012

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BackgroundAlcohol intake has been associated with reduced incidence of common cold symptoms in 2 European studies. However, no study has addressed the association between the frequency of alcohol intake and the incidence of common cold. This study aimed to investigate the association between the amount and frequency of alcohol drinking and the retrospective prevalence of common cold in Japanese men.MethodsThis retrospective study included men who participated in an annual health examination conducted in Sendai, Japan. The frequency of common cold episodes in the previous year was self-reported. The weekly frequency and amount of alcohol consumed, as well as the type of alcoholic drink, were reported by a brief-type self-administered diet history questionnaire. Logistic regression models were used to analyze the association between the amount and frequency of alcohol intake and the retrospective prevalence of common cold.ResultsAmong 899 men, 83.4% of the subjects reported drinking alcohol, and 55.4% of the subjects reported having experienced at least one episode of common cold in the previous year. Compared with non-drinkers, the adjusted odds ratios (ORs) with 95% confidence intervals (CIs) for having had 1 or more episodes of common cold during the past year across categories of alcohol intake frequency of 3 or less, 4–6, and 7 days/week were 0.827 (0.541–1.266), 0.703 (0.439–1.124), and 0.621 (0.400–0.965), respectively (P for trend = 0.025); the adjusted ORs with 95% CIs for having had of 2 or more episodes of common cold across the same categories were 0.642 (0.395–1.045), 0.557 (0.319–0.973), and 0.461 (0.270–0.787), respectively (P for trend = 0.006). Compared with subjects who consumed 11.5–35.8 g of alcohol per day, the non-drinkers were significantly more likely to experience 2 or more episodes of common cold (OR, 1.843; 95% CI, 1.115–3.047).ConclusionThe frequency, not the amount, of alcohol intake was significantly related to lower prevalence of self-reported common cold episodes in Japanese men.

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“…[45] The overproduction of NO is an important cause of inflammation reaction. [4647] Moreover, the pathological role of TNF-α in ethanol- and endotoxin-caused liver injury, derived from experimental models, has also been demonstrated.…”

Section: Discussionmentioning

confidence: 99%

Protective effects of quercetin on liver injury induced by ethanol

Chen

2010

Phcog Mag

116

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Quercetin, a natural compound of multiple origins, has broad biopharmacological effects, such as antioxidant, directly scavenging free radical, and hepatoprotectivity effects. This study is designed to investigate the interveneous effect of quercetin on liver injury induced by ethanol in rats. The rats that were orally treated with 50% ethanol for continuous ten days, which resulted in cell necrosis, fibrosis and inflammatory infiltration, were included in this study. Higher contents of AST, ALT ADH, γ-GT, TG in plasma and MDA in liver tissue, and lower content of GSH in liver tissue were highlighted in ethanol-treated rats when compared with healthy ones. The levels of cytokines such as IL-1β, IL-1, IL-6, IL-8, and TNF-α in rats plasma were also significantly enhanced, and level of IL-10 was obviously lowered through ethanol treatment. By preventive and synchronism treatment with quercetin for fourteen days, the contents of AST, ALT ADH, γ-GT, TG and MDA, and levels of IL-1β, IL-1, IL-6, IL-8, and TNF-α were significantly reduced, whereas GSH and level of IL-10 were obviously increased. It may be deduced that quercetin, by multiple mechanisms interplay, demonstrated somewhat protective effect on liver injury induced by ethanol in rats.

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Binge Drinking and Nitric Oxide Metabolites in Chronic Liver Disease

Cited by 25 publications

References 38 publications

Ethanol Metabolism and Effects: Nitric Oxide and its Interaction

Ethanol Metabolism and Effects: Nitric Oxide and its Interaction

Frequent alcohol drinking is associated with lower prevalence of self-reported common cold: a retrospective study

Protective effects of quercetin on liver injury induced by ethanol

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