Binge Drinking and Risk of Breast Cancer: Results from the SUN (‘Seguimiento Universidad de Navarra’) Project

Sánchez-Bayona, Rodrigo; Gea, Alfredo; Gardeazabal, Itziar; Romanos-Nanclares, Andrea; Martínez‐González, Miguel Ángel; Bes–Rastrollo, Maira; Santisteban, Marta; Toledo, Estefanía

doi:10.3390/nu12030731

Cited by 8 publications

(4 citation statements)

References 33 publications

(40 reference statements)

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“…Our data also did not allow us to determine the timing of alcohol consumption during the day or week, the quantity consumed per drinking occasion, or whether alcohol was consumed alone or with a meal. 32,37,38 We also relied on self-reported alcohol use, which can be prone to recall bias; however, it has been shown that alcohol levels are highly reproducible using food records and 24-hour recalls. 39,40 Finally, although we adjusted for multiple confounders related to alcohol exposure and the study outcomes, including abstainer bias, residual confounding cannot be completely ruled out.…”

Section: Discussionmentioning

confidence: 99%

“…However, most women (84.4%) remained in the same or adjacent category of intake at follow‐up. Our data also did not allow us to determine the timing of alcohol consumption during the day or week, the quantity consumed per drinking occasion, or whether alcohol was consumed alone or with a meal 32,37,38 . We also relied on self‐reported alcohol use, which can be prone to recall bias; however, it has been shown that alcohol levels are highly reproducible using food records and 24‐hour recalls 39,40 .…”

Section: Discussionmentioning

confidence: 99%

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Alcohol consumption and prognosis and survival in breast cancer survivors: The Pathways Study

Kwan

Valice

Ergas

et al. 2023

Cancer

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BackgroundThe impact of alcohol consumption on breast cancer (BC) prognosis remains unclear.MethodsThe authors examined short‐term alcohol intake in relation to recurrence and mortality in 3659 women who were diagnosed with stage I–IV BC from 2003 to 2015 in the Pathways Study. Alcohol drinking in the past 6 months was assessed at cohort entry (mean, 2 months postdiagnosis) and 6 months later using a food‐frequency questionnaire. Study end points were recurrence and death from BC, cardiovascular disease, and all causes. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using multivariable Cox proportional hazards models.ResultsOver an average follow‐up of 11.2 years, 524 recurrences and 834 deaths (369 BC‐specific and 314 cardiovascular disease‐specific) occurred. Compared with nondrinkers (36.9%), drinkers were more likely younger, more educated, and current or past smokers. Overall, alcohol consumption was not associated with recurrence or mortality. However, women with higher body mass index (BMI ≥ 30 kg/m2) had lower risk of overall mortality with increasing alcohol consumption for occasional drinking (HR, 0.71; 95% CI, 0.54–0.94) and regular drinking (HR, 0.77; 95% CI, 0.56–1.08) around the time of diagnosis, along with 6 months later, in a dose‐response manner (p < .05). Women with lower BMI (<30 kg/m2) were not at higher risk of mortality but were at possibly higher, yet nonsignificant, risk of recurrence for occasional drinking (HR, 1.29; 95% CI, 0.97–1.71) and regular drinking (HR, 1.19; 95% CI, 0.88–1.62).ConclusionsAlcohol drinking around the time of and up to 6 months after BC diagnosis was associated with lower risk of all‐cause mortality in obese women. A possible higher risk of recurrence was observed in nonobese women.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Alcohol consumption and prognosis and survival in breast cancer survivors: The Pathways Study

Kwan

Valice

Ergas

et al. 2023

Cancer

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“…Women in the binge drinking group had a higher risk of breast cancer (HR = 1.76; 95% CI 1.03–2.99) than those in the non-binge drinking category. In the stratified analysis, a twofold higher risk for premenopausal breast cancer was associated with a binge drinking habit (HR = 2.06; 95% CI 1.11–3.82) [ 42 ].…”

Section: Alcohol Effects On Breast Cancermentioning

confidence: 99%

Alcohol and breast cancer

2022

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Breast cancer is one of the main causes of death in women worldwide. In women, breast cancer includes over half of all tumours caused by alcohol. This paper discusses both ethanol metabolism and the mechanisms of mammary tumourigenesis caused by alcohol. Numerous signalling pathways in neoplastic transformation following alcohol consumption in women have been presented. In addition, primary and secondary prevention, phytochemicals, synthetic chemicals, specific inhibitors of enzymes and selective receptor modulators have been described.

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“…The Mediterranean Diet Score proposed by Trichopoulou et al [26] was used to evaluate the adherence to the Mediterranean dietary pattern, excluding alcohol intake. We considered alcohol consumption as a separate covariate given the growing evidence on its association with several ORC [27,28]. The questionnaire also gathered information on the participants' average time of sunlight exposure.…”

Section: Covariate Assessmentmentioning

confidence: 99%

Vitamin D and Risk of Obesity-Related Cancers: Results from the SUN (‘Seguimiento Universidad de Navarra’) Project

et al. 2022

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Obesity is associated with a higher risk of several types of cancer, grouped as obesity-related cancers (ORC). Vitamin D deficiency is more prevalent in obese subjects, and it has been suggested to play a role in the association between obesity and cancer risk. The aim of the study was to analyze the association between vitamin D intake and the subsequent risk of ORC in a prospective Spanish cohort of university graduates. The SUN Project, initiated in 1999, is a prospective dynamic multipurpose cohort. Participants answered a 556-item lifestyle baseline questionnaire that included a validated food-frequency questionnaire. We performed Cox regression models to estimate the hazard ratios (HRs) of ORC according to quartiles of energy-adjusted vitamin D intake (diet and supplements). We included 18,017 participants (mean age = 38 years, SD = 12 years), with a median follow-up of 12 years. Among 206,783 person-years of follow-up, we identified 225 cases of ORC. We found no significant associations between vitamin D intake and ORC risk after adjusting for potential confounders: HRQ2vsQ1 = 1.19 (95% CI 0.81–1.75), HRQ3vsQ1 = 1.20 (95% CI 0.81–1.78), and HRQ4vsQ1 = 1.02 (95% CI 0.69–1.51). Dietary and supplemented vitamin D do not seem to be associated with ORC prevention in the middle-aged Spanish population.

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Binge Drinking and Risk of Breast Cancer: Results from the SUN (‘Seguimiento Universidad de Navarra’) Project

Cited by 8 publications

References 33 publications

Alcohol consumption and prognosis and survival in breast cancer survivors: The Pathways Study

Alcohol consumption and prognosis and survival in breast cancer survivors: The Pathways Study

Alcohol and breast cancer

Vitamin D and Risk of Obesity-Related Cancers: Results from the SUN (‘Seguimiento Universidad de Navarra’) Project

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