Binge‐like ethanol exposure during the early postnatal period impairs eyeblink conditioning at short and long CS–US intervals in rats

Tran, Tuan Q.; Stanton, Mark E.; Goodlett, Charles R.

doi:10.1002/dev.20226

Cited by 25 publications

(48 citation statements)

References 94 publications

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“…CRs to the long CS in PD23 and PD30 subjects occurred with greater frequency and were enhanced in amplitude relative to PD45 and PD70 subjects. These age differences are in contrast to that observed in single-cue delay EBC, in which levels of conditioning to a long-ISI CS are similar between adolescent and adult rats (see Tran, Stanton, & Goodlett, 2007). This suggests that age differences reported here are primarily due to enhanced influence of the short CS-US pairing on long CS conditioning, consistent to that reported in ISI discrimination training in Brown et al (2006).…”

Section: Resultscontrasting

confidence: 69%

Cross‐Modal transfer of the conditioned eyeblink response during interstimulus interval discrimination training in young rats

Brown

Stanton

2008

Developmental Psychobiology

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Eyeblink classical conditioning (EBC) was observed across a broad developmental period with tasks utilizing two interstimulus intervals (ISIs). In ISI discrimination, two distinct conditioned stimuli (CSs; light and tone) are reinforced with a periocular shock unconditioned stimulus (US) at two different CS-US intervals. Temporal uncertainty is identical in design with the exception that the same CS is presented at both intervals. Developmental changes in conditioning have been reported in each task beyond ages when single-ISI learning is well developed. The present study sought to replicate and extend these previous findings by testing each task at four separate ages. Consistent with previous findings, younger rats (postnatal day -PD -23 and 30) trained in ISI discrimination showed evidence of enhanced cross-modal influence of the short CS-US pairing upon long CS conditioning relative to older subjects. ISI discrimination training at PD43-47 yielded outcomes similar to those in adults (PD65-71). Cross-modal transfer effects in this task therefore appear to diminish between PD30 and PD43-47. Comparisons of ISI discrimination with temporal uncertainty indicated that cross-modal transfer in ISI discrimination at the youngest ages did not represent complete generalization across CSs. ISI discrimination undergoes a more protracted developmental emergence than single-cue EBC and may be a more sensitive indicator of developmental disorders involving cerebellar dysfunction.

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Section: Resultscontrasting

confidence: 69%

Cross‐Modal transfer of the conditioned eyeblink response during interstimulus interval discrimination training in young rats

Brown

Stanton

2008

Developmental Psychobiology

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“…One argument about alcohol’s effects is that it may impact learning of more difficult tasks (Beylin et al 2001). In other words, alcohol will have its greatest effects when conditioned responding is weak (but see Tran, Stanton & Goodlett, 2007). With Delay and Trace conditioning procedures, trace conditioning typically results in weaker responding than delay.…”

Section: General Methodsmentioning

confidence: 99%

An animal model of fetal alcohol spectrum disorder: Trace conditioning as a window to inform memory deficits and intervention tactics

Hunt

Barnet

2015

Physiology & Behavior

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Animal models of Fetal Alcohol Spectrum Disorders (FASD) afford the unique capacity to precisely control timing of alcohol exposure and alcohol exposure amounts in the developing animal. These models have powerfully informed neurophysiological alterations associated with fetal and perinatal alcohol. In two experiments presented here we expand use of the Pavlovian Trace Conditioning procedure to examine cognitive deficits and intervention strategies in a rat model of FASD. Rat pups were exposed to 5 g/kg/day ethanol on postnatal days (PD) 4–9, simulating alcohol exposure in the third trimester in humans. During early adolescence, approximately PD 30, the rats were trained in the trace conditioning task in which a light conditioned stimulus (CS) and shock unconditioned stimulus (US) were paired but separated by a 10-s stimulus free trace interval. Learning was assessed in freezing behavior during shock-free tests. Experiment 1 revealed that neonatal ethanol exposure significantly impaired hippocampus-dependent trace conditioning relative to controls. In Experiment 2 a serial compound conditioning procedure known as ‘gap filling’ completely reversed the ethanol-induced deficit in trace conditioning. We also discuss prior data regarding the beneficial effects of supplemental choline and novel preliminary data regarding the pharmacological cognitive enhancer physostigmine, both of which mitigate the alcohol-induced cognitive deficit otherwise seen in trace conditioning controls. We suggest trace conditioning as a useful tool for characterizing some of the core cognitive deficits seen in FASD, and as a model for developing effective environmental as well as nutritional and pharmacological interventions.

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“…At high doses of ethanol during the third-trimester equivalent, eye-blink conditioning is impaired in juvenile and adult offspring (Green, Johnson, Goodlett, & Steinmetz, 2002; Green, Tran, Steinmetz, & Goodlett, 2002; Tran, Stanton, & Goodlett, 2007). Gestational exposures have not been tested, as this task is cerebellar dependent and the majority of cerebellar maturation occurs neonatally, during the third-trimester equivalent (Bayer et al, 1993, White & Sillitoe, 2013).…”

Section: Learning Memory and Executive Control (Cognitive)mentioning

confidence: 99%

The impact of prenatal alcohol exposure on social, cognitive and affective behavioral domains: Insights from rodent models

Marquardt

Brigman

2016

Alcohol

129

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Fetal Alcohol Spectrum Disorders (FASD) are characterized by deficits in working memory, response inhibition, and behavioral flexibility. However, the combination and severity of impairments are highly dependent upon maternal ethanol consumption patterns, which creates a complex variety of manifestations. Rodent models have been essential in identifying behavioral endpoints of prenatal alcohol exposure (PAE). However, experimental model outcomes are extremely diverse based on level, pattern, timing, and method of ethanol exposure, as well as the behavioral domain assayed and paradigm used. Therefore, comparisons across studies are difficult and there is currently no clear comprehensive behavioral phenotype of PAE. This lack of defined cognitive and behavioral phenotype is a contributing factor to the difficulty in identifying FASD individuals. The current review aims to critically examine preclinical behavioral outcomes in the social, cognitive, and affective domains in terms of the PAE paradigm, with a special emphasis on dose, timing, and delivery, to establish a working model of behavioral impairment. In addition, this review identifies gaps in our current knowledge and proposes future areas of research that will advance knowledge in the field of PAE outcomes. Understanding the complex behavioral phenotype, which results from diverse ethanol consumption will allow for development of better diagnostic tools and more critical evaluation of potential treatments for FASD.

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Binge‐like ethanol exposure during the early postnatal period impairs eyeblink conditioning at short and long CS–US intervals in rats

Cited by 25 publications

References 94 publications

Cross‐Modal transfer of the conditioned eyeblink response during interstimulus interval discrimination training in young rats

Cross‐Modal transfer of the conditioned eyeblink response during interstimulus interval discrimination training in young rats

An animal model of fetal alcohol spectrum disorder: Trace conditioning as a window to inform memory deficits and intervention tactics

The impact of prenatal alcohol exposure on social, cognitive and affective behavioral domains: Insights from rodent models

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