Binge-like intake of sucrose reduces the rewarding value of sucrose in adult rats

Smail-Crevier, Rachel; Maracle, Amanda C.; Wash, Sarah I.J.; Olmstead, Mary C.

doi:10.1016/j.physbeh.2018.06.027

Cited by 21 publications

(25 citation statements)

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“…Whether the observed gene upregulation is specific to cocaine self-administration or would be observed with passive cocaine intake is not known. Also, we did not observe similar MOP gene regulation in the HPC following a binge sucrose (Smail-Crevier et al, 2018) paradigm F I G U R E 1 Cocaine self-administration in rats. Rats followed a cocaine self-administration paradigm for 10 days (Cocaine-SA, 2 hr/ day) with each infusion delivering 0.33 mg/kg of cocaine, or saline for the control animals (Saline-SA).…”

Section: Role Of Hippocampal Mop In Hpc Following Cocaine-sacontrasting

confidence: 73%

“…Whether the observed gene upregulation is specific to cocaine self‐administration or would be observed with passive cocaine intake is not known. Also, we did not observe similar MOP gene regulation in the HPC following a binge sucrose (Smail‐Crevier et al., 2018) paradigm (data not shown), suggesting that natural rewards may not modify MOP expression in this brain region. Moreover, there are scarce data on MOP gene alterations following drug‐SA in HPC.…”

Section: Discussionmentioning

confidence: 56%

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Hippocampal mu opioid receptors are modulated following cocaine self‐administration in rat

Nogueira

Bourdy

Filliol

et al. 2021

Eur J of Neuroscience

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Addiction is a multifactorial disease involving genetic, psychological, and environmental factors, which has detrimental consequences for individuals and society. It is characterized by excessive intake over time, craving, continued drug use despite negative consequences and relapse (Koob & Volkow, 2016). The progression of addiction is associated with neuroplastic changes (Robinson & Kolb, 1999;Ron & Jurd, 2005), whereby altered gene expression impacts neuronal function and behavior (

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Section: Role Of Hippocampal Mop In Hpc Following Cocaine-sacontrasting

confidence: 73%

Section: Discussionmentioning

confidence: 56%

Hippocampal mu opioid receptors are modulated following cocaine self‐administration in rat

Nogueira

Bourdy

Filliol

et al. 2021

Eur J of Neuroscience

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“…In sum, rodent models of sucrose bingeing provide valuable insight into the behavioural and biological underpinnings of maladaptive eating. Restricting access to palatable food increases the propensity to binge, leading to alterations in reward processing (Smail-Crevier et al, 2018) as well as neurophysiological changes associated with compulsive responding (Maracle et al, 2018). We now identify a contribution of MORs to binge eating, findings that may translate to clinical treatment (Ziauddeen et al, 2013).…”

Section: Discussionmentioning

confidence: 77%

Deletion of mu opioid receptors reduces palatable solution intake in a mouse model of binge eating

Awad

Roeckel

Massotte

et al. 2020

Behavioural Pharmacology

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Binge eating in humans is driven by hedonic properties of food, suggesting that brain reward systems may contribute to this behaviour. We examined the role of mu opioid receptors (MOP) in binge eating by examining sweet solution intake in mice with genetic deletion of the MOP. Wildtype (WT) and MOP knockout (KO) mice had 4 hr access to food in the home cage combined with limited (4 hr) access to sucrose (17.1% w/v) or saccharin (.09% w/v), or continuous (24 hr) access to sucrose. Only limited access groups exhibited binge intake, measured as increased solution consumption during the first hour. KO mice consumed less solution and food during the first hour as well as less food each day compared to WT mice. Limited access groups consumed more food and gained more weight than continuous access groups, and the effect was magnified in saccharin-consuming mice. Indeed, the increased food consumption in animals given limited access to saccharin was so excessive that caloric intake of this group was significantly higher than either of the sucrose groups (limited or continuous access). Within this group, females consumed more food per bodyweight than males, highlighting important sex differences in feeding behaviours under restricted access schedules.

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“…The approach for this experiment was to allow rats to have access to chow and 10% sucrose either 12 or 24 h per day. Similar to [13], a primary dependent measure was to examine how this manipulation affected sucrose intake in a one-hour daily access period (0800 h).…”

Section: Methodsmentioning

confidence: 99%

“…An extension of the choice procedure is the binge intake model where rats are provided access to a sweet solution for either 12 or 24h per day. Rats in the 12h condition drink more sweet solution during the first hour of daily access [13]. Sex differences in binging of fat or a palatable mixture (fat + sugar) have been described, with females binging more than males [14], [15].…”

Section: Introductionmentioning

confidence: 99%

Submitted as a Research Report to Biology of Sex Differences

Grimm

North

Hopkins

et al. 2021

Preprint

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Background: There are sex differences in addiction behaviors. To develop a pre-clinical animal model to investigate this, the present study examined sex differences in sucrose taking and seeking using LongEvans rats. Methods: Five experiments were conducted using separate groups of subjects. The first two examined sucrose or saccharin preference in two-bottle home cage choice tests. Experiment three assessed sucrose intake in a binge model with sucrose available in home cage bottles. Experiments four and five utilized operant-based procedures. In Experiment four rats responded for sucrose on fixed and progressive ratio (FR, PR) schedules of reinforcement over a range of concentrations of sucrose. A final component of experiment four was measuring seeking in the absence of sucrose challenged with the dopamine D1 receptor antagonist SCH23390. Experiment five assessed responding for water on FR and PR schedules of reinforcement. Results: When accounting for body weight, female rats consumed more sucrose than water; but there was no sex difference in saccharin preference over a range of saccharin concentrations. When accounting for body weight, females consumed more sucrose than males in the binge model, and only females increased binge intake over the 14 days of the study. Females responded at higher rates for sucrose under both FR and PR schedules of reinforcement. Females responded at higher rates in extinction (seeking); SCH23390 reduced sucrose seeking of both females and males. Females responded at higher rates for water on FR and PR schedules than males, although rates of responding were low and decreased over sessions. Conclusions: Across bottle-choice, binge intake, and operant procedures, female Long-Evans rats consumed more sucrose and responded at higher rates for sucrose. Although females also responded more for water, the vigor of responding did not explain the consistent sex difference in sucrose taking and seeking. The sex difference in sucrose taking was also not explained by sweet preference, as there was no sex difference in saccharin preference. These data corroborate with findings of sex differences in addiction behaviors in humans, providing a pre-clinical model to further evaluate sex differences in these behaviors and manipulations designed to reduce them.

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Binge-like intake of sucrose reduces the rewarding value of sucrose in adult rats

Cited by 21 publications

References 50 publications

Hippocampal mu opioid receptors are modulated following cocaine self‐administration in rat

Hippocampal mu opioid receptors are modulated following cocaine self‐administration in rat

Deletion of mu opioid receptors reduces palatable solution intake in a mouse model of binge eating

Submitted as a Research Report to Biology of Sex Differences

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