Binocular endogenous Clostridium septicum endophthalmitis

Lindland, Are; Slagsvold, Jon Erik

doi:10.1111/j.1600-0420.2006.00771.x

Cited by 12 publications

(5 citation statements)

References 6 publications

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“…This is in contrast to the results obtained by the following authors: Christensen et al. (2004), who described four cases of bilateral bacterial endogenous endophthalmitis; Lindland & Slagsvold (2007), who recently reported a case of bilateral clostridium endophthalmitis; and Jackson et al. (2003), who reported that 12% of the reviewed patients had bilateral endogenous bacterial endophthalmitis.…”

Section: Discussioncontrasting

confidence: 90%

Endogenous endophthalmitis: microorganisms, disposition and prognosis

Neß

Pelz

Hansen

2007

Acta Ophthalmologica Scandinavica

132

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ABSTRACT.Purpose: Endogenous endophthalmitis is a severe and potentially blinding complication caused by haematogenous spreading of microorganisms. We evaluated the causative microorganisms, disposition to and prognosis of the disease. Methods: Thirty-one eyes of 28 patients were treated between 1996 and 2006 as the result of an endogenous endophthalmitis. Results: The microorganisms responsible for infection could be identified in 94% of all eyes investigated. Candida isolates were obtained in 15, gram-positive isolates in 11, gram-negative in one and Aspergillus in two of the 29 eyes studied. The majority of patients suffered from severe general disease (immunodeficiency, severe surgical procedures, diabetes mellitus) and one third were intravenous drug abusers. Only one patient was otherwise healthy. The prognosis depended on the causative microorganisms. Whereas none of the eyes with Candida infection became blind, all except two of the eyes with gram-positive bacteria, Nocardia or Aspergillus infection lost visual function or had to be enucleated. Conclusion: Compared to postoperative endophthalmitis, patients with endogenous endophthalmitis are more likely to have Candida isolates. Visual prognosis depends mainly on the underlying microorganisms, and is particularly poor in the case of infection with gram-positive bacteria or Aspergillus.

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Section: Discussioncontrasting

confidence: 90%

Endogenous endophthalmitis: microorganisms, disposition and prognosis

Neß

Pelz

Hansen

2007

Acta Ophthalmologica Scandinavica

132

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“…10,11 Series published by Essman et al,Okada et al and Schiedler et al have reported that bilateral cases are more common among fungi than bacteria [12][13][14]. In our study, 22.2% of the patients had at least one systemic 222…”

supporting

confidence: 52%

Clinical Profile and Treatment Outcome of Endogenous Endophthalmitis

Amena Bintay Yousuf Muna,

Alam,

Polak Kumar Das

et al. 2024

Khwaja Yunus Ali Medical College Journal

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Background: Endogenous Endophthalmitis is a sight threatening intraocular infection resulting from hematogenous spread of pathogens from distant foci.Objective: To find out the source, risk factors, microbiological profile, visual and anatomical outcome of management of Endogenous endophthalmitis.Materials and Methods: A retrospective study was done from medical records of diagnosed case of Endogenous Endophthalmitis at Vision Eye Hospital, Dhaka. Data collection was done on demographic factors, medical and surgical history, infectious data, BCVA throughout the clinical course and complications. Visual outcome and anatomical outcome were measured and compared.Results: 20 Eyes of 18 patients were diagnosed as Endogenous Endophthalmitis where 88.9% were unilateral and 11.1% were bilateral. Known foci of infection were found in 27.8% of cases and infective foci were not found on 33.3%. 44.4% were culture positive where the commonest organism was Pseudomonas followed by Klebsiella. 70% patients were treated by PPV and 30% were treated conservatively. Among 18 patients 6 had normal eyeball, 7 had formed eyeball, 3 developed phthisis bulbi and 1 needed enucleation. Finally, VA improved at 44.4% patients, remain unchanged at 22.2% patients and deteriorated at 33.3% patients. Conclusion: The prognosis of endogenous endophthalmitis is often poor despite treatment. A high index of suspicion, early diagnosis and prompt treatment are crucial to salvage vision and eye. KYAMC Journal Volume: 14, No: 04, January 2024: 220-225.

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“…[ 3 4 17 ] There are reports of bilateral cases of EE demonstrated with bacteria such as Clostridium. [ 18 19 ]…”

Section: Discussionmentioning

confidence: 99%

Clinical profile and outcome of endogenous endophthalmitis at a quaternary referral centre in south India

Pillai

Remadevi

Anilkumar

et al. 2020

Indian J Ophthalmol

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Purpose: The purpose of this study is to evaluate the clinical profile, visual, anatomical and survival outcome of patients with endogenous endophthalmitis. Methods: Retrospective chart review of consecutive cases with endogenous endophthalmitis presenting from 2009-2016. Results: In our study, 41 eyes of 34 patients were included. Most common co-morbidity associated with endogenous endophthalmitis was Diabetes Mellitus (70.7%) and most common infective foci was UTI (73.2%). Among the culture positive cases, fungi and bacteria were evenly distributed, 76.93% were Gram positive bacteria and 23.07% were Gram negative. Fungal endogenous endophthalmitis was more commonly seen in immunosuppressed state (72.7%) and bilateral cases (66.7%). The mean presenting vision (log MAR) of patients who died during the study were poor compared to those who survived ( P = 0.014) Poor mean visual acuity at presentation was associated with more death ( P = 0.014). Eyes with poor presenting vision, fungal isolates, culture positivity and immune suppression had poor visual and survival outcome. Poor visual outcome was observed more frequently in eyes with Aspergillus infection (85.7%) compared to Candida (75%) and bacteria (58.3%). Evisceration was done for 5 out of 41 eyes (12.2%). Vitrectomy rate was 53.7% in our study, with 40% of them showing overall improvement in vision. Conclusion: Endogenous endophthalmitis is a sight threatening condition associated with high mortality particularly when caused by Aspergillus spp. in immunocompromised patients. Contrary to the prior published reports of endogenous endophthalmitis outside India, we found an equal distribution of fungal and bacterial organisms among our cases, with predominance of Aspergillus among fungal isolates and Gram-positive organism among bacteria. Fungal infections, especially with Aspergillus spp., resulted in poor visual and survival outcome.

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Binocular endogenous Clostridium septicum endophthalmitis

Cited by 12 publications

References 6 publications

Endogenous endophthalmitis: microorganisms, disposition and prognosis

Endogenous endophthalmitis: microorganisms, disposition and prognosis

Clinical Profile and Treatment Outcome of Endogenous Endophthalmitis

Clinical profile and outcome of endogenous endophthalmitis at a quaternary referral centre in south India

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