In this study we investigate a generalization of modified Pell sequence, which is called (s,t)-modified Pell sequence. By considering this sequence, we define the matrix sequence whose elements are (s,t)-modified Pell numbers. Furthermore, we define various binomial transforms for modified (s,t)-Pell matrix sequence. Finally, we give some relationships for (s,t)-modified Pell matrix sequences such as Binet formulas, the generating functions and some sum formulas...