Binuclear derivatives of phenylmercaptoacetic acid and their tris(2-hydroxyethyl)ammonium salts. Effect on the functional activity of thrombocytes

Photocontrol of Polar Aromatic Interactions by a Bis‐Hemithioindigo Based Helical Receptor

“…Bis‐HTI 1 was synthesized in a short, convergent, and highly modular fashion (Scheme ). The central tricyclic bis‐thiophenone ring 7 was obtained by twofold intramolecular Friedel–Crafts acylation, starting from the already described bis‐acid 6 . The light sensitive compound 7 was not isolated but directly subjected to the condensation reaction with two equivalents of biphenyl aldehyde 5 , yielding bis‐HTI 1 .…”

“…The central tricyclic bis-thiophenone ring 7 was obtained by twofold intramolecular Friedel-Craftsa cylation, starting from the already describedb is-acid 6. [12] The light sensitivec ompound 7 was not isolated but directly subjected to the condensation reaction with two equivalents of biphenyl aldehyde 5,y ielding bis-HTI 1.A ldehyde 5 was synthesized in two steps through Suzuki cross-coupling from the known precursors 2 [13] and 4 [14] (see the Supporting Information for more details).…”

The Ritter reaction mechanism: new corroboration in the synthesis of arylsulfonyl(thio)propionic acid N-(1-adamantyl)amides

“…15 These latter were chosen as substrates in the Ritter reaction for the synthesis of new derivatives of arylsulfonyl(thio)carboxylic acids 16 including pharmacologically active compounds. 17 It is likely that the mechanism of the test reaction can be represented by Scheme 3.…”