Binuclear Heteroleptic Ru(III) Dithiocarbamate Complexes: A Step towards Tunable Antiproliferative Agents

Abstract

Binuclear dithiocarbamate complexes of Ru(III) are promising candidates in the search for outstanding metal-based anticancer agents. While different dithiocarbamates have shown ligand-dependent cytotoxicity in homoleptic binuclear Ru(III) complexes, the properties of heteroleptic analogues with different dithiocarbamate (DTC) ligands have yet to be explored. We herein propose the introduction of heteroleptic ligands as tunable features for the development of improved ruthenium-based antiproliferative agents and report a synthetic strategy for their synthesis as well as the evaluation of the cytotoxic activity of a selection of binuclear heteroleptic Ru(III) compounds towards MDA-MB-231 and PC3 cells.

Synthesis, Characterisation, and in vitro Cytotoxic Activity of Dithiocarbamato Glycoconjugate Half‐Sandwich Ruthenium and Osmium Complexes

“…In particular, the strong band recorded at 1548 cm −1 can be undoubtedly attributed to the stretching vibration involving the dithiocarbamato moiety, ν(N‐CSS). This band, which is shifted to higher energy compared with that observed for 1 (1492 cm −1 ), is consistent with a chelating dithiocarbamato ligand coordinated to a metal centre [85–87] . Additionally, a shoulder is recorded at 1015 cm −1 and assigned to the antisymmetric stretching of the S−C−S moiety, which supports the presence of a bidentate dithiocarbamato group symmetrically coordinated to the metal centre [88–90] …”

Recyclable functionalized polyethyleneimine‐coated magnetic nanoparticles for efficient removal of lead from aqueous solutions

“…The spectrum of MNP@PEI‐CS 2 (Fig. 1(E)) contains bands assigned to the thiouride moiety at 1450–1550 cm −1 32 . Frequencies between those of CN (1250–1350 cm −1 ) and CN (1632 cm −1 ) bonds indicate that a partial double‐bond character exists and the consequent delocalization of π ‐electron density on the dithiocarbamate group 33 .…”

Design, Synthesis, and Characterization of an Amphiphilic Lipoic Acid-Based Ru(III) Complex as a Versatile Tool for the Functionalization of Different Nanosystems

“…To retard this process, at least until the drug has been effectively internalized into cells [29], a common, extensively used approach is based on the choice of metal coordinating ligands less susceptible to the displacement operated by water molecules. In addition, ligands to be preferred should be molecules able to favor the self-assembly of the final complex in solution and to protect the metal core [30][31][32][33][34][35].…”