Experiments performed on rats have shown that a single intravenous injection of the antitumor preparations platidiam and pharmorubicine in the maximum tolerated dose cause morphological changes in the liver which are preserved for 3 months after platidiam and for 6 moths after pharmorubicine. Instability of reparative processes iaa the liver was revealed when the rats were poisoned with CCI 4 1, 3, and 6 months after adlninistration of the cytostatics.