Bio-Active Products from Mangrove Ecosystems

Lin, Wenhan; Li, Guoqiang; Xu, Jing

doi:10.3390/md21040239

Cited by 7 publications

(7 citation statements)

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“…In conclusion, five new naphthalene derivatives (1)(2)(3)(4)6), a new natural product (5) and eighteen known compounds (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24) were isolated from mangrove endophytic fungus Daldinia eschscholzii MCZ-18. Compounds 1 and 2 are naphthalenes bearing a rare ribofuranoside substituted at C-1 and the 5-methyltetrahydrofuran-2,3-diol moiety, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…3 methyls, five sp 3 methylenes, two sp 3 methines, two sp 3 quaternary carbons (including a dioxysubstituted sp 3 carbon at δ C 115.8 (C-1 ′ )), three sp 2 olefinic methines, and four sp 2 nonprotonated carbons (including one ketone carbonyl), as supported by the DEPT and HSQC spectra. 1 H-1 H COSY spectrum (Figure 2) suggested the presence of fragments of -CH 2 (2)-CH 2 (3)-, -CH(5)-CH(6)-CH(7)-, -CH 2 (9)-CH 2 (10)-, and -CH(2 ′ )-CH 2 (3 ′ )-CH(4 ′ )-CH 3 (5 ′ ), suggesting that 2 contains a tetralone skeleton and a 5-methyltetrahydrofuran- further supported the atom connectivity in compound 2. The relative configuration of 2 was assigned by analysis of the NOESY spectrum (Figure 3).…”

Section: Structure Elucidationmentioning

confidence: 99%

“…1 HNMR data of 1-6.3 7.18, d (6.8) Ha 2.76, m 6.37, d (8.0) 4.37, dd (3.2, 2.8) Hb 2.63, m 4 5.13, d (2.8) 5 7.91, d (8.7)…”

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confidence: 99%

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New Naphthalene Derivatives from the Mangrove Endophytic Fungus Daldinia eschscholzii MCZ-18

Xu,

Feng,

Wen

et al. 2024

Marine Drugs

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Five new naphthalene derivatives dalesconosides A–D, F (1–4, 6), a known synthetic analogue named dalesconoside E (5), and eighteen known compounds (7–24) were isolated from Daldinia eschscholzii MCZ-18, which is an endophytic fungus obtained from the Chinese mangrove plant Ceriops tagal. Differing from previously reported naphthalenes, compounds 1 and 2 were bearing a rare ribofuranoside substituted at C-1 and the 5-methyltetrahydrofuran-2,3-diol moiety, respectively. Their structures were determined by detailed nuclear magnetic resonance (NMR) and mass spectroscopic (MS) analyses, while the absolute configurations were established by theoretical electronic circular dichroism (ECD) calculation. Compounds 1, 3, 13–17 and 19 showed broad ranges of antimicrobial spectrum against five indicator test microorganisms (Enterococcus faecalis, Methicillin-resistant Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans); especially, 1, 16 and 17 were most potent. The variations in structure and attendant biological activities provided fresh insights concerning structure−activity relationships for the naphthalene derivatives.

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Section: Discussionmentioning

confidence: 99%

Section: Structure Elucidationmentioning

confidence: 99%

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New Naphthalene Derivatives from the Mangrove Endophytic Fungus Daldinia eschscholzii MCZ-18

Xu,

Feng,

Wen

et al. 2024

Marine Drugs

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“…Research indicates that among these, ten species possess medicinal value. These species are Acanthus ilicifolius (mouse thorn), Cerbera manghas (Cerbera manghas), Excoecaria agallocha (blinding tree), Avicennia marina (grey mangrove), Aegiceras corniculatum (river mangrove), Sonneratia caseolaris (crabapple mangrove), Excoecaria agallocha (sea poison tree), Barringtonia racemosa (powderpuff tree), Hibiscus tiliaceus (beach hibiscus), and Bridelia micrantha (small-leafed bridelia) [13].…”

Section: Utilization Of Coastal Medicinal Plantsmentioning

confidence: 99%

Characteristics and Analysis of Dominant Diseases in Jing Nationality Medicine

Liu,

Gan,

Zhao

et al. 2023

OJIM

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Jing medicine occupies a very prominent position in the traditional culture of the Chinese nation and has unique advantages. Through the literature review of Jing medicine, the author has a deeper understanding of Jing medicine in Guangxi. This paper mainly shows the traditional characteristic medicine culture of the Jing nationality and discusses the characteristic therapy and medication characteristics of Jing nationality medicine, which is conducive to the improvement of people's cognition of Jing nationality medicine and the development and innovation of Jing nationality medicine.

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“…Mangrove-derived microorganisms in intertidal microenvironments are tolerant to numerous stresses, including highly saline or brackish water, high solar irradiation, and tidal gradients. The special ecological niche induced certain buds being evolved to encode unique biosynthetic genes that have the potential to generate unique bioactive metabolites [ 1 , 2 ], which increasingly attracted the attention of both pharmaceutical and natural product chemists [ 3 , 4 ]. A therapeutic molecule from the mangrove environment is now available in the market and exemplified by salinosporamide A (Marizomib ® ), which is a fermentation product of mangrove-derived Salinispora tropica CNB-392 [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Metabolomics-Guided Discovery of New Dimeric Xanthones from Co-Cultures of Mangrove Endophytic Fungi Phomopsis asparagi DHS-48 and Phomopsis sp. DHS-11

Wu,

Chen,

et al. 2024

Marine Drugs

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The co-culture strategy, which mimics natural ecology by constructing an artificial microbial community, is a useful tool for the activation of biosynthetic gene clusters (BGCs) to generate new metabolites, as well as to increase the yield of respective target metabolites. As part of our project aiming at the discovery of structurally novel and biologically active natural products from mangrove endophytic fungi, we selected the co-culture of a strain of Phomopsis asparagi DHS-48 with another Phomopsis genus fungus DHS-11, both endophyted in mangrove Rhizophora mangle considering the impart of the taxonomic criteria and ecological data. The competition interaction of the two strains was investigated through morphology observation and scanning electron microscopy (SEM), and it was found that the mycelia of the DHS-48 and DHS-11 compacted and tangled with each other with an interwoven pattern in the co-culture system. A new approach that integrates HPLC chromatogram, 1HNMR spectroscopy, UPLC-MS-PCA, and molecular networking enabled the targeted isolation of the induced metabolites, including three new dimeric xanthones phomoxanthones L-N (1–3), along with six known analogs (4–9). Their planar structures were elucidated by an analysis of their HRMS, MS/MS, and NMR spectroscopic data and the absolute configurations based on ECD calculations. These metabolites showed broad cytotoxic activity against the cancer cells assessed, of which compounds 7–9 displayed significant cytotoxicity towards human liver cells HepG-2 with IC50 values ranging from 4.83 μM to 12.06 μM. Compounds 1–6 exhibited weak immunosuppressive activity against the proliferation of ConA-induced (T-cell) and LPS-induced (B-cell) murine splenic lymphocytes. Therefore, combining co-cultivation with a metabolomics-guided strategy as a discovery tool will be implemented as a systematic strategy for the quick discovery of target bioactive compounds.

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Bio-Active Products from Mangrove Ecosystems

Abstract: Mangrove communities represent the coastal habitats located in intertidal zones or brackish waters of tropical and subtropical coastal areas in over 118 countries [...]

Cited by 7 publications

References 10 publications

New Naphthalene Derivatives from the Mangrove Endophytic Fungus Daldinia eschscholzii MCZ-18

New Naphthalene Derivatives from the Mangrove Endophytic Fungus Daldinia eschscholzii MCZ-18

Characteristics and Analysis of Dominant Diseases in Jing Nationality Medicine

Metabolomics-Guided Discovery of New Dimeric Xanthones from Co-Cultures of Mangrove Endophytic Fungi Phomopsis asparagi DHS-48 and Phomopsis sp. DHS-11

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