Bio-Applications of Nanopillars

Abstract

Bio-applications of nanopillars are discussed, with a focus on the advantages nanopillared surfaces compared to flat surfaces and the properties of nanopillars behind each application are explained. Enhancing cell adhesion and growthNanopillars also possess a unique geometry that strengthens their interaction with cells. The placement of nanopillars in an ordered array encourages cells to position themselves in between pillars while wrapping the ends of their membranes around the pillars for increased support. This essentially creates a "pinning" effect by which the cell

Functional Nanomaterials and Nanostructures Enhancing Electrochemical Biosensors and Lab-on-a-Chip Performances: Recent Progress, Applications, and Future Perspective

“…Nanopillars, vertically aligned nanowire arrays on a lateral surface, have typical diameters and heights around a few hundred nanometers and submicrometer to a few micrometers, respectively . Their structure and morphologies introduce a significant surface area while maintaining the overall dimensions of the original substrate.…”

“…Nanopillars, vertically aligned nanowire arrays on a lateral surface, have typical diameters and heights around a few hundred nanometers and submicrometer to a few micrometers, respectively. 387 Their structure and morphologies introduce a significant surface area while maintaining the overall dimensions of the original substrate. In particular, nanopillars are very attractive to use in electrochemical biosensors as the increased active surface area can increase the current output similar to nanowires, and provide large surface area for modification of biomolecules or other chemical functionalities.…”

“…Lotwala and Ji provide a good overview for further reading regarding the effects of nanopillar introduction on the electrochemistry of electrodes. 391 In addition to being a transducer, nanopillars can enhance cell adhesion and growth as well as the ability to penetrate cells, 387 which make them very attractive for biomedical research. Nanopillars for cell capturing, especially for circulating tumor cells (CTCs), have been extensively reported because cells favor the binding on nanotopographic surfaces.…”

A Biomimetic Nano‐Engineered Platform for Functional Tissue Engineering of Cartilage Superficial Zone

“…The cells are typically adherent to the nanopillar tips and do not penetrate between the nanofeatures as shown in Figure S3, Supporting Information, in which the filopodia mostly extend along the nanopillar tips rather than in the valleys. [ 39 ]…”

“…Nanopillars affect the amount of adsorbed proteins like collagen and improve cell adhesion. [ 39 ] Therefore, while the cells have a flattened spherical/ellipsoidal shape on Silk‐PIII‐Nanopillar‐KGN, the expressed collagen fibers are aligned parallel to the surface mimicking the SZ of articular cartilage.…”