Bio-based Large Tablet Controlled-Release Urea: Synthesis, Characterization, and Controlled-Released Mechanisms

Liu, Lu; Shen, Tze-Min; Yang, Yuechao; Gao, Bin; Li, Yuncong; Xie, Jiazhuo; Tang, Yafu; Wang, Zhonghua; Chen, Jianqiu

doi:10.1021/acs.jafc.8b04042

Cited by 54 publications

(41 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The processing methods for controlled release fertilizers include (1) solvent evaporation-induced phase separation for microcarriers, (2) solution coating on fertilizer granules with/without heat reaction, (3) cold-compressing pellets of fertilizers and binders, and (4) extrusion/melt-blending for polymer/fertilizer composite tablets/films [2,[18][19][20][21]. Extrusion or melt blending for the preparation of controlled release nitrogen fertilizers (such as urea and nitrogen inhibitor) is particularly attractive because the process is simple, cheap, and does not involve solvents, high pressure, or reactive mixing [19,20,22,23].…”

Section: Introductionmentioning

confidence: 99%

Degradable Controlled Release Fertilizer Composite Prepared via Extrusion: Fabrication, Characterization, and Release Mechanisms

2020

View full text Add to dashboard Cite

In this work, biodegradable polymers were melt compounded with urea phosphate to fabricate “smart fertilizers” for sustainable agriculture. Urea phosphate (UP) is typically applied as a water-soluble fertilizer to treat phosphorus deficiency in high pH soils. Due to the low diffusion rate of phosphate through slow-release fertilizer coatings, phosphate supply has been considered the “bottleneck” for nitrogen–phosphorous–potassium (NPK) nutrients supply. We study the influence of polymer matrix structure on release kinetics in deionized water using novel polyesters including poly (hexamethylene succinate) (PHS), poly (30% butylene succinate-co-70% hexamethylene succinate) (PBHS 30/70), and PBHS 70/30. Melt processed composites of UP and polyester were analyzed to determine UP loading efficiency and dispersion and distribution of the salt in the polymer matrix. A combined empirical model involving diffusion and erosion mechanisms was found have a good agreement with the experimental release curve. This work provides a solution for environmentally friendly controlled release phosphate fertilizer with good release performance using bio-based and biodegradable polymers.

show abstract

Section: Introductionmentioning

confidence: 99%

Degradable Controlled Release Fertilizer Composite Prepared via Extrusion: Fabrication, Characterization, and Release Mechanisms

2020

View full text Add to dashboard Cite

show abstract

“…Formation of composite wraps or coatings is therefore desired. In one of the works published by Yang et al, nano-silica was added to coatings made of bio-polyol and methylene diphenyl diisocyanate (MDI) to reduce the porosity through -OH cross-linking, thus extending release longevity of the coated urea tablet [ 100 ] (Fig. 5 a).…”

Section: Nano-fabricated Fertilizersmentioning

confidence: 99%

Recent development in functional nanomaterials for sustainable and smart agricultural chemical technologies

2022

View full text Add to dashboard Cite

New advances in nanotechnology are driving a wave of technology revolution impacting a broad range of areas in agricultural production. The current work reviews nanopesticides, nano-fabricated fertilizers, and nano activity-based growth promoters reported in the last several years, focusing on mechanisms revealed for preparation and functioning. It appears to us that with many fundamental concepts have been demonstrated over last two decades, new advances in this area continue to expand mainly in three directions, i.e., efficiency improvement, material sustainability and environment-specific stimulation functionalities. It is also evident that environmental and health concerns associated with nano agrochemicals are the primary motivation and focus for most recent work. Challenges and perspectives for future development of nano agrochemicals are also discussed.

show abstract

“…The majority of studies have been focused on enhancing drug bioavailability and reducing dosing frequencies [ 11 , 12 ]. This can be achieved by several pharmaceutical approaches, including, for example, coating systems [ 13 ], osmotic pressure systems [ 14 ], and matrices systems [ 15 ]. They can be made of polymers [ 16 , 17 ], lipids [ 18 ], chitosan [ 19 ], starch [ 20 ], cellulose [ 21 ], polyester amide [ 22 ], polycarbonates [ 23 ], or hydroxypropyl methylcellulose (HPMC) [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

In Vitro and In Vivo Evaluation of Oral Controlled Release Formulation of BCS Class I Drug Using Polymer Matrix System

et al. 2021

View full text Add to dashboard Cite

Diltiazem hydrochloride is a calcium channel blocker, which belongs to the family of benzothiazepines. It is commonly used to treat hypertension and atrial fibrillation. Even though the drug has high solubility, its high permeability and rapid metabolism in the liver can limit the bioavailability and increase the dose frequencies for up to four times per day. This study focused on a polymer matrix system not only to control the drug release but also to prolong the duration of bioavailability. The polymer matrices were prepared using different ratios of poloxamer-188, hydroxypropyl methylcellulose, and stearyl alcohol. In vitro and in vivo assessments took place using 24 rabbits and the results were compared to commercially available product Tildiem® (60 mg tablet) as reference. Overall, the rate of drug release was sustained with the gradual increase of poloxamer-188 incorporated with hydroxypropyl methylcellulose and stearyl alcohol in the matrix system, achieving a maximum release period of 10 h. The oral bioavailability and pharmacokinetic parameters of diltiazem hydrochloride incorporated in polymer matrix system were similar to commercial reference Tildiem®. In conclusion, the combination of polymers can have a substantial effect on controlling and prolonging the drug release pattern. The outcomes showed that poloxamer-188 combined with hydroxypropyl methylcellulose and stearyl alcohol is a powerful matrix system for controlling release of diltiazem hydrochloride.

show abstract

Bio-based Large Tablet Controlled-Release Urea: Synthesis, Characterization, and Controlled-Released Mechanisms

Cited by 54 publications

References 42 publications

Degradable Controlled Release Fertilizer Composite Prepared via Extrusion: Fabrication, Characterization, and Release Mechanisms

Degradable Controlled Release Fertilizer Composite Prepared via Extrusion: Fabrication, Characterization, and Release Mechanisms

Recent development in functional nanomaterials for sustainable and smart agricultural chemical technologies

In Vitro and In Vivo Evaluation of Oral Controlled Release Formulation of BCS Class I Drug Using Polymer Matrix System

Contact Info

Product

Resources

About