BIO bragg gratings on microfibers for label-free biosensing

Juste-Dolz, Augusto; Delgado-Pinar, M.; Avella-Oliver, Miquel; Fernández, Esther; Pastor, D.; Andrés, Miguel V.; Maquieira, Ángel

doi:10.1016/j.bios.2020.112916

Cited by 17 publications

(16 citation statements)

References 44 publications

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“…Compared with the traditional methods, such as PCR and ELISA, the optical fiber-based immunological sensor method has the advantages of high sensitivity, simple operation, and monitored real-time and thus has become a hot research topic. According to different working principles, the main types of optical fiber biosensors include optical fiber interferometer [10,11], fiber surface plasmon resonance [12,13], fiber grating [14,15], and whispering-gallery-mode resonator [16,17]. Among them, the interferometer biosensor is widely concerned due to the advantages of high sensitivity, low cost, and simple fabrication.…”

Section: Introductionmentioning

confidence: 99%

Tapered Microfiber MZI Biosensor for Highly Sensitive Detection of Staphylococcus Aureus

Leng

Liao

et al. 2022

IEEE Sensors J.

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A new double-taper microfiber Mach-Zehnder interferometer (MZI) biosensor is applied for Staphylococcus aureus (S. aureus) detection. The microfiber MZI structure is fabricated by creating two tapers along a traditional single mode fiber (SMF) firstly and tapering the SMF sandwiched between two tapers into very small diameter (in the order of micrometers). The measured refractive index (RI) sensitivity of the microfiber MZI is up to 2731.1 nm/RIU in the RI range of 1.34 when the taper waist diameter was 10.2 µm, which is in good agreement with numerical simulation results by using the beam propagation method (BPM). The microfiber MZI functionalized with pig immunoglobulin (pig IgG) could be used to specifically binding to S. aureus. In experiment, the maximum wavelength shift of 1.408 nm was achieved when the microfiber biosensors were immersed into S. aureus with concentration of 7×10 1 CFU/mL. The limit of detection (LoD) of the microfiber biosensor for S. aureus is calculated as low as 11 CFU/mL. The proposed microfiber MZI biosensor has advantages of simple structure configuration, high sensitivity, good repeatability and specificity, wide detection range and fast detection response time (<30 minutes) and thus was demonstrated a good application prospect in food safety inspection, biochemical sensing, diseases and medical diagnostics.

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Section: Introductionmentioning

confidence: 99%

Tapered Microfiber MZI Biosensor for Highly Sensitive Detection of Staphylococcus Aureus

Leng

Liao

et al. 2022

IEEE Sensors J.

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“…Gratings in different formats have also been applied for the label-free detection of biomolecules [ 32 , 33 ]. Diffractive structures of bioreceptors have been patterned on the surface of optical waveguides and tailored to transduce the magnitude of biorecognition assays into the intensity of single peaks in the reflection spectrum [ 34 ]. In these approaches, the grating response changes after the biorecognition event takes place and it results in a modification of its diffraction efficiency.…”

Section: Introductionmentioning

confidence: 99%

Processing of Holographic Hydrogels in Liquid Media: A Study by High-Performance Liquid Chromatography and Diffraction Efficiency

et al. 2022

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The storage of time-stable holographic gratings in hydrogel matrices when the material is immersed in aqueous media is a real challenge at present. The optimization of the storage stages of the holograms must be properly investigated to identify the most suitable development processes. For this reason, this work is focused on the study of the optimization of the washing stages of the hydrogels based on acrylamide and N,N’-methylenebis(acrylamide) once unslanted transmission holograms have been stored. High-performance liquid chromatography and UV-visible measurements have been employed in our system to analyze the composition of the washing solutions. PBST and DMSO:H2O are used as solvents in the washing stages. The diffraction efficiencies are measured during the washing stages and after the storing of the holograms during several days in PBST. Maximum diffraction efficiencies of 38 and 27.6% are reached when PBST and DMSO:H2O are employed, respectively, for the washing process. Holograms show temporal stability after being stored immersed in PBST at 4 °C for 4 days.

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“…To address the limitations of conventional techniques for immunosensing, optical fiber sensors, including interferometric fiber-optic sensors [ 14 ], microfiber Bragg gratings [ 15 , 16 , 17 , 18 ], tilted fiber Bragg gratings (TFBG) [ 19 ], surface polarized resonance (SPR) [ 20 , 21 ], and long-period fiber gratings (LPFG) [ 22 , 23 ], were proposed as a biophotonic platform for antibody–antigen interaction monitoring and specific biomolecules’ detection. Among them, LPFGs with various structures and surface modifications were of great interest as immunosensors due to their high sensitivity, outstanding mechanical structure, easy fabrication, good biocompatibility, and free-label detection [ 23 , 24 , 25 , 26 , 27 , 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

All Fiber-Optic Immunosensors Based on Elliptical Core Helical Intermediate-Period Fiber Grating with Low-Sensitivity to Environmental Disturbances

et al. 2022

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An all fiber-optic immunosensor based on elliptical core helical intermediate-period fiber grating (E-HIPFG) is proposed for the specific detection of human immunoglobulin G (human IgG). E-HIPFGs are all-fiber transducers that do not include any additional coating materials or fiber architectures, simplifying the fabrication process and promising the stability of the E-HIPFG biosensor. For human IgG recognition, the surface of an E-HIPFG is functionalized by goat anti-human IgG. The functionalized E-HIPFG is tested by human IgG solutions with a concentration range of 10–100 μg/mL and shows a high sensitivity of 0.018 nm/(μg/mL) and a limit of detection (LOD) of 4.7 μg/mL. Notably, the functionalized E-HIPFG biosensor is found to be insensitive to environmental disturbances, with a temperature sensitivity of 2.6 pm/°C, a strain sensitivity of 1.2 pm/με, and a torsion sensitivity of −23.566 nm/(rad/mm). The results demonstrate the considerable properties of the immunosensor, with high resistance to environmental perturbations, indicating significant potential for applications in mobile biosensors and compact devices.

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BIO bragg gratings on microfibers for label-free biosensing

Cited by 17 publications

References 44 publications

Tapered Microfiber MZI Biosensor for Highly Sensitive Detection of Staphylococcus Aureus

Tapered Microfiber MZI Biosensor for Highly Sensitive Detection of Staphylococcus Aureus

Processing of Holographic Hydrogels in Liquid Media: A Study by High-Performance Liquid Chromatography and Diffraction Efficiency

All Fiber-Optic Immunosensors Based on Elliptical Core Helical Intermediate-Period Fiber Grating with Low-Sensitivity to Environmental Disturbances

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