Bio-cellular processes modeling on silicon substrate: receptor–ligand binding and Michaelis Menten reaction

Analog Electronic Circuits to Model Cooperativity in Hill Process

“…This section proposes some possible MOS transistor equivalents to model Hill process. The equivalences and electronic circuit validations stated in [17] suggest that a single MOS transistor operating in analog mode can model a non-linear bio-cellular reaction like receptor-ligand binding or Michaelis Menten kinetics. The drain and gate voltages are analogous to ligand and receptor concentrations respectively.…”

“…For Hill process model, another transistor has been cascaded, whose gate voltage is proportional to the drain current of the first transistor as shown in Fig. 2 [17], the drain current I " flowing through the short channel transistor M is given as Equation 4.…”

“…Although the bio-cellular processes are immensely complex in their interactions, a finite set of biochemical reaction underlie them. A modular approach is to efficiently model these fundamental bio-chemical reactions in analog electronic domain anticipating that this would make modeling of larger networks easy [2,17]. This paper presents an extension to the work published by the author in [17] in which two such processes namely receptor-ligand binding and Michaelis Menten reaction, were modeled using analog transistors in electronic domain.…”

“…A modular approach is to efficiently model these fundamental bio-chemical reactions in analog electronic domain anticipating that this would make modeling of larger networks easy [2,17]. This paper presents an extension to the work published by the author in [17] in which two such processes namely receptor-ligand binding and Michaelis Menten reaction, were modeled using analog transistors in electronic domain. This work presents several approaches to model a third fundamental reaction called the Hill process with argumentative and simulation support.…”