The human body regularly produces mucus, and its presence does not mean that something bad is going on. The boundary tissues of mammals, including the nose, throat and lungs, serve as a barrier against pollution and are produced by our respiratory system. Our work describes the flow comprehension of the components moulding the fluid elements of respiratory irresistible infections. A mathematical model is introduced to concentrate on the mucus fluid flow driven by natural convection through asymmetric channel. This study also summarized biological disorder of human lung build-up fluid. The nonlinear governing equations contain importance of heat transfer and fluid motion of mucus fluid. The analytic solutions of unsteady mucus flow through an isothermal channel with thermal conduction are accomplished adopting Laplace transform method. Significance of mucus fluid heat source thermal conductivity on momentum distribution and energy distribution is enumerated. The comparison of various dimensionless parameters is shown graphically with the help of MATLAB software. In order to provide some understanding on the behavior of mucus fluids and heat transfer mechanisms, extension of this study explores at how temperature influences mucus flow properties.