Bio-derived and biocompatible poly(lactic acid)/silk sericin nanogels and their incorporation within poly(lactide-<i>co</i>-glycolide) electrospun nanofibers

Kongprayoon, Arisa; Ross, Gareth; Limpeanchob, Nanteetip; Mahasaranon, Sararat; Punyodom, Winita; Topham, Paul D.; Ross, Sukunya

doi:10.1039/d2py00330a

Cited by 23 publications

(12 citation statements)

References 42 publications

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“…Polymer materials remain a popular choice for controlled release systems, having garnered significant attention and being utilized in numerous domains, such as pharmaceuticals, medicine, agriculture, and material science. These materials include polymeric lyotropic liquid crystal (e.g., micelles [ 1 ] and cubosome [ 2 ]), capsules [ 3 ], nanofibers [ 4 , 5 ], and hydrogels [ 6 ]. Hydrogel systems are particularly suited for controlled release thanks to their advantageous inherent properties, such as high water contents and tailored mechanical strength.…”

Section: Introductionmentioning

confidence: 99%

Homo- and Copolymer Hydrogels Based on N-Vinylformamide: An Investigation of the Impact of Water Structure on Controlled Release

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Ross

Phewchan

et al. 2023

Gels

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This study investigated the performance of novel hydrogels based on poly (N-vinylformamide) (PNVF), copolymers of NVF with N-hydroxyethyl acrylamide (HEA) (P(NVF-co-HEA)), and 2-carboxyethyl acrylate (CEA) (P(NVF-co-CEA)), which were synthesized by photopolymerization using a UVLED light source. The hydrogels were analyzed for important properties such as equilibrium water content (%EWC), contact angle, freezing and non-freezing water, and diffusion-based in vitro release. The results showed that PNVF had an extremely high %EWC of 94.57%, while a decreasing NVF content in the copolymer hydrogels led to a decrease in water content with a linear relationship with HEA or CEA content. Water structuring in the hydrogels showed appreciably more variance, with ratios of free to bound water differing from 16.7:1 (NVF) to 1.3:1 (CEA), corresponding to PNVF having ~67 water molecules per repeat unit. The release studies of different dye molecules followed Higuchi’s model, with the amount of dye released from the hydrogels depending on the amount of free water and the structural interactions between the polymer and the molecule being released. The results suggest that PNVF copolymer hydrogels have potential for controlled drug delivery by altering the polymer composition to govern the amount and ratio of free to bound water contained in the hydrogels.

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Section: Introductionmentioning

confidence: 99%

Homo- and Copolymer Hydrogels Based on N-Vinylformamide: An Investigation of the Impact of Water Structure on Controlled Release

Yooyod

Ross

Phewchan

et al. 2023

Gels

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“…Poly( l -lactide) (PLLA), generally termed “PLA”, is currently one of the most widely used sustainable polymers that exhibits both biodegradability and tissue compatibility. Materials containing PLA have been designed and fabricated in various forms, such as nanogels, films, nanofibers, and 3D printing [ 11 , 12 , 13 , 14 ]. PLA is a brittle plastic with high mechanical strength; therefore, many researchers have investigated ways to improve its mechanical properties, especially its ductility or %elongation [ 15 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

In Situ Compatibilized Blends of PLA/PCL/CAB Melt-Blown Films with High Elongation: Investigation of Miscibility, Morphology, Crystallinity and Modelling

et al. 2023

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Ternary-blended, melt-blown films of polylactide (PLA), polycaprolactone (PCL) and cellulose acetate butyrate (CAB) were prepared from preliminary miscibility data using a rapid screening method and optical ternary phase diagram (presented as clear, translucent, and opaque regions) as a guide for the composition selection. The compositions that provided optically clear regions were selected for melt blending. The ternary (PLA/PCL/CAB) blends were first melt-extruded and then melt-blown to form films and characterized for their tensile properties, tensile fractured-surface morphology, miscibility, crystallinity, molecular weight and chemical structure. The results showed that the tensile elongation at the break (%elongation) of the ternary-blended, melt-blown films (85/5/10, 75/10/15, 60/15/25 of PLA/PCL/CAB) was substantially higher (>350%) than pure PLA (ca. 20%). The range of compositions in which a significant increase in %elongation was observed at 55–85% w/w PLA, 5–20% w/w PCL and 10–25% w/w CAB. Films with high %elongation all showed good interfacial interactions between the dispersed phase (PCL and CAB) and matrix (PLA) in FE-SEM and showed improvements in miscibility (higher intermolecular interaction and mixing) and a decrease in the glass transition temperature, when compared to the low %elongation films. The decrease in Mw and Mn and the formation of the new NMR peaks (1H NMR at 3.68–3.73 ppm and 13C NMR at 58.54 ppm) were observed in only the high %elongation films. These are expected to be in situ compatibilizers that are generated during the melt processing, mostly by chain scission. In addition, mathematical modelling was used to study the optimal ratio and cost-effectiveness of blends with optimised mechanical properties. These ternary-blended, melt-blown films have the potential for use in both packaging and medical devices with excellent mechanical performance as well as inherent economic and environmental capabilities.

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“…The material used must have the appropriate mechanical strength, biocompatibility, and degradation profile to facilitate bridging the nerve gap defect, which needs to offer clinical options for further use. A wide variety of different biomaterials derived from synthetic aliphatic polyesters are biodegradable materials with good biocompatibility, such as polylactide, polycaprolactone, polyglycolide and their copolymers. − For peripheral nerve repair, poly( l -lactide- co -ε-caprolactone) (PLCL) and poly( l -lactide- co -glycolide) (PLGA) are of interest for use in the fabrication of NGCs. However, PLCL and PLGA have some drawbacks that limit their growth stimulation and proliferation during tissue regeneration due to their poor hydrophilicity. − , In general, surface modification of these biopolymers has been applied to facilitate better matching of the properties of the native tissue.…”

Section: Introductionmentioning

confidence: 99%

Surface-Modified Polypyrrole-Coated PLCL and PLGA Nerve Guide Conduits Fabricated by 3D Printing and Electrospinning

et al. 2022

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The efficiency of nerve guide conduits (NGCs) in repairing peripheral nerve injury is not high enough yet to be a substitute for autografts and is still insufficient for clinical use. To improve this efficiency, 3D electrospun scaffolds (3D/E) of poly(l-lactide-co-ε-caprolactone) (PLCL) and poly(l-lactide-co-glycolide) (PLGA) were designed and fabricated by the combination of 3D printing and electrospinning techniques, resulting in an ideal porous architecture for NGCs. Polypyrrole (PPy) was deposited on PLCL and PLGA scaffolds to enhance biocompatibility for nerve recovery. The designed pore architecture of these “PLCL-3D/E” and “PLGA-3D/E” scaffolds exhibited a combination of nano- and microscale structures. The mean pore size of PLCL-3D/E and PLGA-3D/E scaffolds were 289 ± 79 and 287 ± 95 nm, respectively, which meets the required pore size for NGCs. Furthermore, the addition of PPy on the surfaces of both PLCL-3D/E (PLCL-3D/E/PPy) and PLGA-3D/E (PLGA-3D/E/PPy) led to an increase in their hydrophilicity, conductivity, and noncytotoxicity compared to noncoated PPy scaffolds. Both PLCL-3D/E/PPy and PLGA-3D/E/PPy showed conductivity maintained at 12.40 ± 0.12 and 10.50 ± 0.08 Scm–1 for up to 15 and 9 weeks, respectively, which are adequate for the electroconduction of neuron cells. Notably, the PLGA-3D/E/PPy scaffold showed superior cytocompatibility when compared with PLCL-3D/E/PPy, as evident via the viability assay, proliferation, and attachment of L929 and SC cells. Furthermore, analysis of cell health through membrane leakage and apoptotic indices showed that the 3D/E/PPy scaffolds displayed significant decreases in membrane leakage and reductions in necrotic tissue. Our finding suggests that these 3D/E/PPy scaffolds have a favorable design architecture and biocompatibility with potential for use in peripheral nerve regeneration applications.

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Bio-derived and biocompatible poly(lactic acid)/silk sericin nanogels and their incorporation within poly(lactide-co-glycolide) electrospun nanofibers

Abstract: Bio-derived and biocompatible nanogels based on poly(lactic acid) (PLA) and silk sericin (SS) have been synthesized for the first time.

Cited by 23 publications

References 42 publications

Homo- and Copolymer Hydrogels Based on N-Vinylformamide: An Investigation of the Impact of Water Structure on Controlled Release

Homo- and Copolymer Hydrogels Based on N-Vinylformamide: An Investigation of the Impact of Water Structure on Controlled Release

In Situ Compatibilized Blends of PLA/PCL/CAB Melt-Blown Films with High Elongation: Investigation of Miscibility, Morphology, Crystallinity and Modelling

Surface-Modified Polypyrrole-Coated PLCL and PLGA Nerve Guide Conduits Fabricated by 3D Printing and Electrospinning

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