Bio-flavonoids in Radiation Injury

Arons, Isidore; Freeman, John; Sokoloff, Boris; Eddy, Walter H.

doi:10.1259/0007-1285-27-323-642

Cited by 7 publications

(3 citation statements)

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“…Therefore, the search for compounds able to prevent or treat cancer, leading to fewer side effects, has increased. Flavonoid administration has long been suggested to improve the tolerance to cancer treatment in an experimental model of cancer [95]. In addition, more recent studies suggest that flavonoids could be useful in the treatment of several types of cancer, such as skin, stomach, liver, lung and also thyroid cancer [93,96].…”

Section: Flavonoids and Cancermentioning

confidence: 99%

Flavonoids, Thyroid Iodide Uptake and Thyroid Cancer—A Review

Gonçalves

Freitas

Ferreira

2017

IJMS

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Thyroid cancer is the most common malignant tumor of the endocrine system and the incidence has been increasing in recent years. In a great part of the differentiated carcinomas, thyrocytes are capable of uptaking iodide. In these cases, the main therapeutic approach includes thyroidectomy followed by ablative therapy with radioiodine. However, in part of the patients, the capacity to concentrate iodide is lost due to down-regulation of the sodium-iodide symporter (NIS), the protein responsible for transporting iodide into the thyrocytes. Thus, therapy with radioiodide becomes ineffective, limiting therapeutic options and reducing the life expectancy of the patient. Excessive ingestion of some flavonoids has been associated with thyroid dysfunction and goiter. Nevertheless, studies have shown that some flavonoids can be beneficial for thyroid cancer, by reducing cell proliferation and increasing cell death, besides increasing NIS mRNA levels and iodide uptake. Recent data show that the flavonoids apingenin and rutin are capable of increasing NIS function and expression in vivo. Herein we review literature data regarding the effect of flavonoids on thyroid cancer, besides the effect of these compounds on the expression and function of the sodium-iodide symporter. We will also discuss the possibility of using flavonoids as adjuvants for therapy of thyroid cancer.

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Section: Flavonoids and Cancermentioning

confidence: 99%

Flavonoids, Thyroid Iodide Uptake and Thyroid Cancer—A Review

Gonçalves

Freitas

Ferreira

2017

IJMS

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“…It was chemically similar but not identical to the original vitamin P of Rusznyak and Szent‐Györgyi (29). This compound, named C.V.P., was proved experimentally to possess considerable biologic activity (30, 31, 32). It was tested clinically in various conditions in which increased capillary fragility and capillary bleeding occurred.…”

Section: Introductionmentioning

confidence: 99%

“…It was tested clinically in various conditions in which increased capillary fragility and capillary bleeding occurred. The therapeutic usefulness of this bio‐flavonoid compound has been demonstrated in radiation erythema (32, 33), retinitis (34), bleeding duodenal ulcer (35), bleeding cystitis (36), erythroblastosis (37, 38), habitual abortion (39), tuberculous hemoptysis (40), hemorrhagic diatheses (41), otolaryngologic disorders (42, 43), periodontal diseases (44), and in increased capillary fragility in the aged (45). It also reduces the inflammation in bacterial and viral infections (16, 46–50).…”

Section: Introductionmentioning

confidence: 99%