Bio-Hybrid Hydrogels Incorporated into a System of Salicylic Acid-pH/Thermosensitive Nanocarriers Intended for Cutaneous Wound-Healing Processes

Bialik-Wąs, Katarzyna; Miastkowska, Małgorzata; Sapuła, Paulina; Pluta, Klaudia; Chwastowski, Jarosław; Barczewski, Mateusz

doi:10.3390/pharmaceutics14040773

Cited by 10 publications

(2 citation statements)

References 71 publications

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“…A conventional crosslinking method was used to prepare SA/PVA/aloe vera hydrogels using poly(vinyl alcohol), a solution of sodium alginate, ammonium persulfate and a solution of aloe vera, to which glycerine was added 143 to ensure the transparency and flexibility of the membrane. The dried hydrogel was used to measure the tensile strength of the dressings and the amount of aloe vera incorporated affected this; no burst effect was observed during the release of aloe vera, which was beneficial during wound healing.…”

Section: Naturally Occurring Materials Fabricated Into Wound Dressing...mentioning

confidence: 99%

A review of past promises, present realities and a vibrant future for wound dressing from naturally occurring to sustainable materials

H.,

Tripathi,

Bose

2023

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Section: Naturally Occurring Materials Fabricated Into Wound Dressing...mentioning

confidence: 99%

A review of past promises, present realities and a vibrant future for wound dressing from naturally occurring to sustainable materials

H.,

Tripathi,

Bose

2023

RSC Sustain.

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“…Salicylic acid is a non-steroidal anti-inflammatory drug, with antiseptic and analgesic effects. It is frequently used as an active compound in cosmetic products because of its topical effects [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Salicylic Acid Co-Precipitation with Alginate via Supercritical Atomization for Cosmetic Applications

Baldino

Reverchon

2022

Materials

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Alginate-based microparticles were produced via supercritical assisted atomization (SAA) with the aim of obtaining a biocompatible and low-cost carrier for the delivery of active compounds in cosmetic applications. Salicylic acid was selected as an active model compound, and it was co-precipitated with alginate via SAA, operating at 82 bar and 80 °C. In particular, the drug-to-polymer weight ratio was fixed at 1/4, whereas polymer concentration was varied from 5 to 20 mg/mL in the starting aqueous solution. Operating in this way, alginate-salicylic acid microparticles were characterized by a mean diameter of 0.72 ± 0.25 µm, and the active compound became amorphous after processing. A salicylic acid encapsulation efficiency close to 100% was reached, and the drug release time from the biopolymeric microparticles was prolonged up to nine times with respect to untreated salicylic acid powder.

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Inclusion of Reduced Graphene Oxide to Silk Fibroin Hydrogels Improve the Conductive, Swelling and Wound Healing Capacity

Ruiz,

Castro,

Aedo

et al. 2024

ChemistrySelect

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Developing dressing for wound dressings represents a significant challenge for the scientific community. In this study, a conductive hydrogel was synthesized to promote the wound‐healing process. This hydrogel is composed of silk fibroin (SF), reduced graphene oxide (rGO), and glycerol (G). The impact of modifying the SF:rGO ratio, and the G content (%), on the physicochemical and biological properties. The hydrogels were characterized using FT‐IR, SEM, XRD, TGA, swelling, mechanical resistance, and conductivity. The cytotoxicity of the materials and their wound‐healing capacity in human fibroblasts were also determined. Chemical analysis revealed that the gelation of SF occurs due to the formation of β sheet structures, which was confirmed by the shift from amide I to amide II. An Increase in the SF:rGO ratio favored swelling behavior, although increasing G reduced this effect. The swelling of the hydrogel followed a Fick diffusion mechanism. Furthermore, the increase in the SF:rGO ratio and the percentage G improved the conductivity of the materials. The hydrogels were found to be non‐cytotoxic to human fibroblasts, and those containing rGO exhibited superior wound healing capacity compared to the positive control cell culture medium. Therefore, SF:rGO hydrogels could be considered promising candidates for wound dressing.

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Bio-Hybrid Hydrogels Incorporated into a System of Salicylic Acid-pH/Thermosensitive Nanocarriers Intended for Cutaneous Wound-Healing Processes

Cited by 10 publications

References 71 publications

A review of past promises, present realities and a vibrant future for wound dressing from naturally occurring to sustainable materials

A review of past promises, present realities and a vibrant future for wound dressing from naturally occurring to sustainable materials

Salicylic Acid Co-Precipitation with Alginate via Supercritical Atomization for Cosmetic Applications

Inclusion of Reduced Graphene Oxide to Silk Fibroin Hydrogels Improve the Conductive, Swelling and Wound Healing Capacity

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