Bio-inert interfaces via biomimetic anchoring of a zwitterionic copolymer on versatile substrates

Dizon, Gian Vincent; Chou, Ying-Nien; Yeh, Lu-Chen; Huang, James; Chang, Yung

doi:10.1016/j.jcis.2018.05.073

Cited by 23 publications

(17 citation statements)

References 46 publications

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“…Antifouling polymers are often highly hydrophilic polymers, such as polysaccharides, poly(ethylene glycol) (PEG), and poly(zwitterions), that adsorb a great amount of water to form a barrier to reduce nonspecific interactions between biomaterials and biological systems. , The coating methods for surface conjugation of antifouling polymers are generally categorized into “graft-to” and “graft-from” . “Graft-to” refers to physical or chemical immobilization of presynthesized polymers, − while “graft-from” refers to in situ polymerization of hydrophilic monomers from surface-bound initiators. − Some surface coating strategies, such as layer-by-layer (LbL) deposition, chemical vapor deposition (CVD) of functional films, and photoinitiated immobilization, could be applied to a wide range of substrates, but possess certain disadvantages. LbL deposition is usually tedious, time-consuming, and could not survive harsh sterilization conditions.…”

Section: Introductionmentioning

confidence: 99%

Conjugation of Polysulfobetaine via Poly(pyrogallol) Coatings for Improving the Antifouling Efficacy of Biomaterials

et al. 2021

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Antifouling treatment is critical to certain biomedical devices for their functions and patients' life. Facial, versatile, and universal coating methods to conjugate antifouling materials on a wide variety of biomaterials are beneficial for the fabrication of low-fouling biomedical devices. We developed a simple one-step coating method for surface conjugation of zwitterionic poly(sulfobetaine) via deposition of self-polymerized pyrogallol (PG). Poly(pyrogallol) could deposit copolymers of sulfobetaine methacrylate and aminoethyl methacrylate (pSBAE) on various biomaterials. pSBAE coatings inhibited as high as 99.8% of the adhesion of L929 cells and reduced protein adsorption significantly. The resistance against L929 cell adhesion was increased with increasing coating time and was positively correlated with the surface hydrophilicity and film thickness. Such a coating was robust to resist harsh sterilization conditions and stable for long-term storage in phosphate-buffered saline. We expect that the simple lowfouling pSBAE coating is applicable to the manufacture of medical devices.

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Section: Introductionmentioning

confidence: 99%

Conjugation of Polysulfobetaine via Poly(pyrogallol) Coatings for Improving the Antifouling Efficacy of Biomaterials

et al. 2021

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“…Surfaces have been successfully modified with pSBMA using various methods ranging from atom transfer radical polymerization (ATRP), 38,43,45,48 reverse ATRP, 35 plasma-induced polymerization 49 as well as simple grafting-to method via use of a catechol 41 or click chemistry. 50 Utilizing these methods, pSBMA has been applied to gold, 40,45 graphene, 35 glass, 43 silica nanoparticles, 51 silicon, 26,44 as well as other polymers such as PDMS, 34,52,53 cellulose, 38,42 polyurethane, 39 poly(vinylidene fluoride).…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo hemocompatibility assessment of ultrathin sulfobetaine polymer coatings for silicon-based implants

et al. 2019

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Highly uniform silicon nanopore membranes were developed for applications in implantable bioartificial organs. A robust, readily scalable, non-fouling surface coating is required to enhance silicon nanopore membrane hemocompatibility. However, the coating must be ultrathin to keep the nanopores from occluding. Recently, zwitterionic brush polymers have demonstrated significantly lower fouling under biological conditions. In this study, we explore ultrathin zwitterionic poly(sulfobetaine methacrylate) (pSBMA) surface coating at sub-5 nm thickness. Membrane hydraulic permeability was measured before and after surface modification of silicon nanopore membranes, and pores were found to be patent and in agreement with coating thickness measurements. Coating stability was analyzed under biological shear as well as under blood flow in vitro and in vivo. Following exposure to shear over 24 h, coatings were characterized via X-ray photoelectron spectroscopy, goniometry, and ellipsometry, and found to survive biological shear. In vitro blood experiments with fresh human blood as well as in vivo 7-day and 26-day implants in a porcine model demonstrate minimal platelet adhesion and activation with pSBMA surface modification compared to unmodified silicon exposed to fresh human blood in vitro. These results demonstrate that ultrathin pSBMA surface modification is a viable choice for application in blood contacting implants with critical nanoscale features.

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“…Some recent studies have reported facile methods for preparing polySBMA surfaces via mussel-inspired coatings. For example, Dizon et al synthesized a novel zwitterionic copolymer containing a catechol group, which can form a stable coating on various materials [ 39 ]. However, the method necessitates the synthesis of monomers and copolymers via a complicated reaction.…”

Section: Resultsmentioning

confidence: 99%

Superhydrophilic Coating with Antibacterial and Oil-Repellent Properties via NaIO4-Triggered Polydopamine/Sulfobetaine Methacrylate Polymerization

et al. 2020

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Superhydrophilic coatings have been widely used for the surface modification of membranes or biomedical devices owing to their excellent antifouling properties. However, simplifying the modification processes of such materials remains challenging. In this study, we developed a simple and rapid one-step co-deposition process using an oxidant trigger to fabricate superhydrophilic surfaces based on dopamine chemistry with sulfobetaine methacrylate (SBMA). We studied the effect of different oxidants and SBMA concentrations on surface modification in detail using UV–VIS spectrophotometry, dynamic light scattering, atomic force microscopy, X-ray photoelectron spectroscopy, and surface plasmon resonance. We found that NaIO4 could trigger the rate of polymerization and the optimum ratio of dopamine to SBMA is 1:25 by weight. This makes the surface superhydrophilic (water contact angle < 10°) and antifouling. The superhydrophilic coating, when introduced to polyester membranes, showed great potential for oil/water separation. Our study provides a complete description of the simple and fast preparation of superhydrophilic coatings for surface modification based on mussel-inspired chemistry.

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Bio-inert interfaces via biomimetic anchoring of a zwitterionic copolymer on versatile substrates

Cited by 23 publications

References 46 publications

Conjugation of Polysulfobetaine via Poly(pyrogallol) Coatings for Improving the Antifouling Efficacy of Biomaterials

Conjugation of Polysulfobetaine via Poly(pyrogallol) Coatings for Improving the Antifouling Efficacy of Biomaterials

In vitro and in vivo hemocompatibility assessment of ultrathin sulfobetaine polymer coatings for silicon-based implants

Superhydrophilic Coating with Antibacterial and Oil-Repellent Properties via NaIO4-Triggered Polydopamine/Sulfobetaine Methacrylate Polymerization

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