Nowadays, the race between cities for super-tall buildings is increasing. These buildings reach enormous dimensions, exceeding the 300-meter height threshold, and play a decisive role in the iconic character, visual impact, prestige, economic growth, and technological and architectural advancement of cities. (1) Background: The study analyses super-tall buildings regarding nature-inspired design and biophilic criteria in this context. Nature-inspired design and biophilic approach have significant potential to produce innovative architecture and engineering solutions and build sustainable buildings. (2) Methods: The study's method involves assessing the top ten tallest structures in the Council on Tall Buildings and Urban Habitat (CTBUH) database through content analysis. (3) Results: Through data collection facilitated by literature reviews and websites containing information about the buildings, it was found that nature-inspired and biophilic approaches significantly impact the design of super-tall buildings. This study emphasizes that combining super tall designs with nature-inspired and biophilic principles can create a new paradigm in the field of architectural design. This combination offers architectural aesthetics and functional advantages and improves the quality of life by enabling individuals living in urban areas to establish a closer relationship with nature. (4) Conclusions: In this context, nature-inspiration and biophilic design in super tall buildings create spaces that both promote physical-mental well-being and increase interior comfort.