Bio‐Inspired Dopamine Functionalization of Polypyrrole for Improved Adhesion and Conductivity

Zhang, Wei; Yang, Fut K.; Pan, Zihe; Zhang, Jian; Zhao, Boxin

doi:10.1002/marc.201300761

Cited by 84 publications

(56 citation statements)

References 33 publications

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“…Specifically, three peaks at 2962, 2900, and 2840 cm −1 were assigned to aliphatic υ (CH) stretching modes . A broad peak at 3230 cm −1 was attributed to the υ (NH) of PPy and PDA and to the υ (OH) stretching modes . A clear weak feature at 1705 cm −1 was assigned to υ (CO), indicating the presence of quinone groups, which were the result of phenolic hydroxy oxidation on PDA .…”

Section: Resultsmentioning

confidence: 98%

“…Previous works have applied the chemical oxidation of pyrrole and dopamine to fabricate nanofibers . Here, DA was applied for the first time to the construction of biomimetic conductive PPy nanofiber on biomedical titanium via electrochemical polymerizations, which is interesting application of the previous concept to the electrochemical coatings on bone implants.…”

Section: Introductionmentioning

confidence: 99%

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Polydopamine‐Assisted Electrochemical Fabrication of Polypyrrole Nanofibers on Bone Implants to Improve Bioactivity

Wang

Lei

et al. 2016

Macro Materials & Eng

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Dopamine is a molecule that facilitates biomineralization, and it is used to prepare electropolymerization‐induced polydopamine (PDA). For the first time, dopamine is used for template‐free electrochemical polymerization to form biocompatible polypyrrole (PPy) nanofiber coatings on bone implants. Dopamine monomers are electropolymerized to PDA chains affixed to biomedical titanium after the nanomicelles are tuned to self‐assemble by triggering the potential, resulting in nanofiber formation. Dopamine serves as a dopant to induce the formation of conductive PPy nanofibers and as a promoter to accelerate biomineralization, cell proliferation, and adhesion.

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Section: Resultsmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Polydopamine‐Assisted Electrochemical Fabrication of Polypyrrole Nanofibers on Bone Implants to Improve Bioactivity

Wang

Lei

et al. 2016

Macro Materials & Eng

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show abstract

“…Previous results have shown that dopamine-bound Ppy has a higher hydrophilicity and thus a more uniform dispersion in water. [32] Taken together, the characterization of the different scaffolds revealed that the DOPA-based MA-G/PEGDA/Ppy cryogel had the more biomimetic Young's modulus, a better resilience, and a more uniform macroporous network for the growth of cardiomyocytes.…”

Section: Scaffold Characterizationmentioning

confidence: 98%

Mussel‐Inspired Conductive Cryogel as Cardiac Tissue Patch to Repair Myocardial Infarction by Migration of Conductive Nanoparticles

Wang

Jiang

Hua

et al. 2016

Adv Funct Materials

159

130

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The engineered cardiac patch (ECP) is a promising strategy to repair infarct myocardium and restore the cardiac function. An ideal ECP should be able to mimic the primary attributes of native myocardium, which includes a high resilience, good cardiomyocyte adhesion, and synchronous contraction. Here, a mussel‐inspired dopamine crosslinker is used to integrate polypyrrole (Ppy) nanoparticles, gelatin‐methyacrylate, and poly(ethylene glycol) diacrylate into a cryogel form. The dopamine crosslinker and Ppy nanoparticles are coordinated to obtain optimal mechanical and superelastic properties for the ECP. The dopamine facilitates the uniform distribution of the Ppy nanoparticles, which migrate and fuse from the scaffold to the surface of the cardiomyocytes, revealing a potential mechanism for restoring infarct myocardium. The incorporated Ppy nanoparticles thus significantly enhance the functionalization of the cardiomyocytes, resulting in excellent synchronous contraction by increasing the expression of α‐actinin and CX‐43. Cardiomyocytes‐loaded ECP can improve the cardiac function in myocardial‐infarction (MI) affected rat models. The results show that the fractional shortening and ejection fraction are elevated by about 50% and that the infarct size is reduced by 42.6%. Collectively, this study highlights an effective cardiac patch based on mussel‐inspired conductive particle adhesion and a superelastic cryogel promising for the restoration of infarcted myocardium.

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“…The major reason for the focus on use of this particular conducting polymer, in addition to ease of synthesis, processability in aqueous solutions and high conductivity, is largely due to the cytocompatibility of PPy (Fonner et al 2008;George et al 2005;Ramanaviciene et al 2007;Wang et al 2004a;Zhang et al 2001) and its ability to promote cell adhesion (Lee and Schmidt 2014;Molino et al 2013;Thompson et al 2011;Zhang et al 2014).…”

Section: Introductionmentioning

confidence: 99%

From nanoparticles to fibres: effect of dispersion composition on fibre properties

et al. 2015

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A polyvinyl alcohol (PVA)-stabilized polypyrrole nanodispersion has been optimised for conductivity and processability by decreasing the quantity of PVA before and after synthesis. A reduction of PVA before synthesis leads to the formation of particles with a slight increase in dry particle diameter (51 ± 6 to 63 ± 3 nm), and conversely a reduced hydrodynamic diameter. Conductivity of the dried nanoparticle films was not measureable after a reduction of PVA prior to synthesis. Using filtration of particles after synthesis, PVA content was sufficiently reduced to achieve dried thin film conductivity of 2 S cm -1 , while the electroactivity of the dispersed particles remained unchanged. The as-synthesized and PVA-reduced polypyrrole particles were successfully spun into allnanoparticle fibres using a wet-extrusion approach without the addition of any polymer or gel matrix. Using nanoparticles as a starting material is a novel approach, which allowed the production of macroscale fibres that consisted entirely of polypyrrole nanoparticles. Fibres made from PVA-reduced polypyrrole showed higher electroactivity compared to fibres composed of the dispersion high in PVA. The mechanical properties of the fibres were also improved by reducing the amount of PVA present, resulting in a stronger, more ductile and less brittle fibre, which could find potential application in various fields.

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Bio‐Inspired Dopamine Functionalization of Polypyrrole for Improved Adhesion and Conductivity

Cited by 84 publications

References 33 publications

Polydopamine‐Assisted Electrochemical Fabrication of Polypyrrole Nanofibers on Bone Implants to Improve Bioactivity

Polydopamine‐Assisted Electrochemical Fabrication of Polypyrrole Nanofibers on Bone Implants to Improve Bioactivity

Mussel‐Inspired Conductive Cryogel as Cardiac Tissue Patch to Repair Myocardial Infarction by Migration of Conductive Nanoparticles

From nanoparticles to fibres: effect of dispersion composition on fibre properties

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