Bio-Inspired Drug Delivery Systems: From Synthetic Polypeptide Vesicles to Outer Membrane Vesicles

Lu, Yiming; Xu, Yixin; Zhou, Zunkang; Li, Yichong; Wei, Ling; Song, Wenliang

doi:10.3390/pharmaceutics15020368

Cited by 16 publications

(17 citation statements)

References 104 publications

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“…To this end, researchers have explored various drug carriers including hydrogels, 124,125 MOFs, 118,126 and polypeptides. 119 Recently, HCPs have emerged as promising drug delivery materials due to their controlled morphology, highly porous structure, improved dispersibility, relatively lower cytotoxicity, and good biocompatibility.…”

Section: Drug Deliverymentioning

confidence: 99%

“…Evidence from clinical studies has demonstrated targeted therapies can not only precisely target and eradicate tumors, but also minimize the risk of tumor progression. To this end, researchers have explored various drug carriers including hydrogels, 124,125 MOFs, 118,126 and polypeptides 119 . Recently, HCPs have emerged as promising drug delivery materials due to their controlled morphology, highly porous structure, improved dispersibility, relatively lower cytotoxicity, and good biocompatibility.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Section: Biomedical Applicationsmentioning

confidence: 99%

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Rational design of hyper‐crosslinked polymers for biomedical applications

Qian

Kim

Tang

et al. 2023

Journal of Polymer Science

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Hyper‐crosslinked polymers (HCPs) are a family of polymers that possess several desirable characteristics, including high specific surface area, excellent stability, tunable porous structures, and low‐cost reagents. As a result, HCPs have gained significant attention in the areas of gas storage, adsorption, catalysis, separation, and carbon precursors, exhibiting advanced performances in catalytic and energy‐related applications. Recently, researchers have explored the potential of HCPs in biomedical engineering. In this review, we discuss classical synthesis strategies and morphological assembly methods used to create HCPs with unique biological properties. We also highlight the latest advances in emerging biomedical areas of HCPs, such as drug delivery, antimicrobial, bioimaging, and biosensing. By providing various examples, we further discuss the correlations between the structures, morphologies, and enhanced biomedical properties of the HCPs. Finally, we summarize the key applications of HCPs and provide an outlook on the research direction to encourage further development of biomedically available HCPs. Overall, HCPs offer promising potential as a new class of materials for use in biomedical applications, and continued research in this field will lead to exciting discoveries and breakthroughs.

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Section: Drug Deliverymentioning

confidence: 99%

Section: Biomedical Applicationsmentioning

confidence: 99%

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Rational design of hyper‐crosslinked polymers for biomedical applications

Qian

Kim

Tang

et al. 2023

Journal of Polymer Science

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“…Outer membrane vesicles originating from bacteria are of particular importance. Polypeptide vesicles are also widely investigated since they are composed of hydrophobic and hydrophilic chains and they can encapsulate hydrophobic drugs through hydrophobic interactions, hydrophilic drugs through electrostatic interactions, and metal-based drugs via metallic coordination [ 29 ]. Drug release from a polymeric carrier is impacted by its composition, ratios of drug, polymer and excipient, interactions between constituents, and the methods of preparation, and it can be exerted via four different mechanisms (diffusion, solvent, chemical interaction, and stimulated release), which makes them suitable for targeted drug delivery [ 30 ].…”

Section: Formulation Of Emulgelmentioning

confidence: 99%

“…The most commonly used emulsifiers in emulgels are Tween 20 (polysorbate 20) as an emulsifier in the aqueous phase, and Span 20 (sorbitan monolaurate 20) in the oil phase. Other examples of emulsifiers used in emulgel formulations are sorbitan monooleate, polyethylene glycol stearate, stearic acid, and sodium stearate [ 29 , 67 , 75 ].…”

Section: Formulation Of Emulgelmentioning

confidence: 99%

Emulgels: Promising Carrier Systems for Food Ingredients and Drugs

Milutinov,

Krstonošić,

Ćirin

et al. 2023

Polymers

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Novel delivery systems for cosmetics, drugs, and food ingredients are of great scientific and industrial interest due to their ability to incorporate and protect active substances, thus improving their selectivity, bioavailability, and efficacy. Emulgels are emerging carrier systems that represent a mixture of emulsion and gel, which are particularly significant for the delivery of hydrophobic substances. However, the proper selection of main constituents determines the stability and efficacy of emulgels. Emulgels are dual-controlled release systems, where the oil phase is utilized as a carrier for hydrophobic substances and it determines the occlusive and sensory properties of the product. The emulsifiers are used to promote emulsification during production and to ensure emulsion stability. The choice of emulsifying agents is based on their capacity to emulsify, their toxicity, and their route of administration. Generally, gelling agents are used to increase the consistency of formulation and improve sensory properties by making these systems thixotropic. The gelling agents also impact the release of active substances from the formulation and stability of the system. Therefore, the aim of this review is to gain new insights into emulgel formulations, including the components selection, methods of preparation, and characterization, which are based on recent advances in research studies.

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