Bio-inspired encapsulation and functionalization of iron oxide nanoparticles for biomedical applications

Aisida, Samson O.; Akpa, Paul A.; Ahmad, Ishaq; Zhao, Ting-kai; Mâaza, M.; Ezema, Fabian I.

doi:10.1016/j.eurpolymj.2019.109371

Cited by 164 publications

(73 citation statements)

References 213 publications

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“…Physical methods for the preparation of MNPs follow a top-down approach in which bulk materials or large particles are broken into nanoscale particles. While such methods are preferred for the large-scale production of nanoparticles, there are major setbacks regarding uncontrolled particle size, non-uniform size distribution, and time-consuming and expensive technologies [ 31 , 62 ]. There is a variety of physical methods for synthesizing MNPs, including ball milling and electron beam lithography as the most commonly used, and others, such as laser ablation, sputtering, gas-phase deposition and aerosol spray pyrolysis [ 31 , 62 , 63 ].…”

Section: Magnetite Nanoparticles—synthesis Properties and Functimentioning

confidence: 99%

“…While such methods are preferred for the large-scale production of nanoparticles, there are major setbacks regarding uncontrolled particle size, non-uniform size distribution, and time-consuming and expensive technologies [ 31 , 62 ]. There is a variety of physical methods for synthesizing MNPs, including ball milling and electron beam lithography as the most commonly used, and others, such as laser ablation, sputtering, gas-phase deposition and aerosol spray pyrolysis [ 31 , 62 , 63 ]. On the one hand, the principle of ball milling, a solid-state synthesis method, is based on the generation of frictional force through the collision between the surfaces of the reactants, which causes an increase in temperature, pressure, and internal energy [ 64 ].…”

Section: Magnetite Nanoparticles—synthesis Properties and Functimentioning

confidence: 99%

“…Other techniques for the bottom-up synthesis of MNPs include sonochemical, hydrothermal, microwave-assisted, chemical reduction, electrochemical, evaporation-condensation, and solvothermal methods [ 31 ].…”

Section: Magnetite Nanoparticles—synthesis Properties and Functimentioning

confidence: 99%

“…Since they have high surface energies, the capping of the nanoparticles is necessary to prevent agglomeration and stabilize them [ 76 ]. These methods involve the use of bacteria, algae, fungi, and higher plants [ 31 , 62 ]. While biological methods are the most cost-effective and eco-friendly and generate the most biocompatible nanoparticles, publications within the field are still lacking [ 31 ].…”

Section: Magnetite Nanoparticles—synthesis Properties and Functimentioning

confidence: 99%

“…Recent trends are focusing on merging the two directions of application, offering theranostic alternatives for both diagnosis and treatment. Iron oxide nanoparticles, especially magnetite, are highly advantageous due to their biocompatibility, biodegradability, non-toxicity, and ability to specifically target tissue and primary structures that allow for the attachment of various therapeutics [ 29 , 30 , 31 , 32 , 33 , 34 ]. Thus, magnetite nanoparticles (MNPs) and EOs systems could represent a novel and efficient direction in the management of infectious diseases.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Magnetite Nanoparticles and Essential Oils Systems for Advanced Antibacterial Therapies

Mihai

Chircov

Grumezescu

et al. 2020

IJMS

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Essential oils (EOs) have attracted considerable interest in the past few years, with increasing evidence of their antibacterial, antiviral, antifungal, and insecticidal effects. However, as they are highly volatile, the administration of EOs to achieve the desired effects is challenging. Therefore, nanotechnology-based strategies for developing nanoscaled carriers for their efficient delivery might offer potential solutions. Owing to their biocompatibility, biodegradability, low toxicity, ability to target a tissue specifically, and primary structures that allow for the attachment of various therapeutics, magnetite nanoparticles (MNPs) are an example of such nanocarriers that could be used for the efficient delivery of EOs for antimicrobial therapies. The aim of this paper is to provide an overview of the use of EOs as antibacterial agents when coupled with magnetite nanoparticles (NPs), emphasizing the synthesis, properties and functionalization of such NPs to enhance their efficiency. In this manner, systems comprising EOs and MNPs could offer potential solutions that could overcome the challenges associated with biofilm formation on prosthetic devices and antibiotic-resistant bacteria by ensuring a controlled and sustained release of the antibacterial agents.

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Section: Magnetite Nanoparticles—synthesis Properties and Functimentioning

confidence: 99%

Section: Magnetite Nanoparticles—synthesis Properties and Functimentioning

confidence: 99%

Section: Magnetite Nanoparticles—synthesis Properties and Functimentioning

confidence: 99%

Section: Magnetite Nanoparticles—synthesis Properties and Functimentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Magnetite Nanoparticles and Essential Oils Systems for Advanced Antibacterial Therapies

Mihai

Chircov

Grumezescu

et al. 2020

IJMS

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Advanced functional polymer materials for biomedical applications

Elsayed,

Teow

2024

J of Applied Polymer Sci

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Polymer structures are essential in biomedical applications due to their biocompatibility, biodegradability, and ability to form intricate structures on micro‐ to nanometer scales. This review, emphasizing electrospinning and phase inversion techniques, examines the fabrication strategies and chemical design of polymer structures for biomedical use. Electrospinning, particularly needleless electrospinning, produces nanofibres with high porosity and flexibility and is widely applied in tissue engineering and drug delivery. Phase inversion, including thermal, nonsolvent‐, vapor‐ and evaporation‐induced phase separation, allows precise control over polymer properties but faces challenges in terms of cooling rates and solvent characteristics. Chemical design through doping, functionalization, cross‐linking and copolymerization enhances the biocompatibility, biodegradability and mechanical properties of polymers, facilitating advanced applications in drug delivery, tissue scaffolding and biosensors. Advanced functional polymers are revolutionizing biomedical fields, offering innovative solutions for therapeutic medicine delivery, disease detection, diagnostics, and regenerative medicine. Despite remarkable progress, challenges, such as scalability, cost‐effectiveness, and environmental impact, persist. This review underscores the transformative potential of advanced polymer materials in medical treatments and advocates for continuous research and interdisciplinary collaboration to overcome existing challenges and fully exploit the capabilities of these materials in improving patient care and medical outcomes. Future perspectives highlight enhancing precision control mechanisms, integrating phase inversion with other techniques and developing large‐scale production methods to advance the field further.

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Photodynamic therapy: Innovative approaches for antibacterial and anticancer treatments

Kolarikova

Hošíková

Dilenko

et al. 2023

Medicinal Research Reviews

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Photodynamic therapy is an alternative treatment mainly for cancer but also for bacterial infections. This treatment dates back to 1900 when a German medical school graduate Oscar Raab found a photodynamic effect while doing research for his doctoral dissertation with Professor Hermann von Tappeiner. Unexpectedly, Raab revealed that the toxicity of acridine on paramecium depends on the intensity of light in his laboratory. Photodynamic therapy is therefore based on the administration of a photosensitizer with subsequent light irradiation within the absorption maxima of this substance followed by reactive oxygen species formation and finally cell death. Although this treatment is not a novelty, there is an endeavor for various modifications to the therapy. For example, selectivity and efficiency of the photosensitizer, as well as irradiation with various types of light sources are still being modified to improve final results of the photodynamic therapy. The main aim of this review is to summarize anticancer and antibacterial modifications, namely various compounds, approaches, and techniques, to enhance the effectiveness of photodynamic therapy.

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Bio-inspired encapsulation and functionalization of iron oxide nanoparticles for biomedical applications

Cited by 164 publications

References 213 publications

Magnetite Nanoparticles and Essential Oils Systems for Advanced Antibacterial Therapies

Magnetite Nanoparticles and Essential Oils Systems for Advanced Antibacterial Therapies

Advanced functional polymer materials for biomedical applications

Photodynamic therapy: Innovative approaches for antibacterial and anticancer treatments

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